Molecular Formula | C25H22O10 |
Molar Mass | 482.44 |
Density | 1.527±0.06 g/cm3(Predicted) |
Melting Point | 239-241°C |
Boling Point | 793.0±60.0 °C(Predicted) |
Specific Rotation(α) | +16.9 (Me2CO) |
Flash Point | 274.451°C |
Solubility | Soluble in methanol, pyridine, DMSO and other solvents, insoluble in petroleum ether, chloroform. |
Vapor Presure | 0mmHg at 25°C |
Appearance | White-like crystal |
pKa | 7.39±0.60(Predicted) |
Storage Condition | 2-8℃ |
Refractive Index | 1.684 |
MDL | MFCD09842608 |
Physical and Chemical Properties | White powder, soluble in methanol, ethanol, DMSO and other organic solvents, from milk thistle. |
Reference Show more | 1. Zhang Lifang, Lin Xia, Feng Xinghai, et al. Optimization of ultrasonic assisted organic solvent reflux extraction of silymarin from silymarin seeds [J]. Chinese patent medicine, 2019, 41(001):185-188. |
Plant Source: | Milk Thistle |
function | has hepatoprotective, antioxidant and antitumor effects |
Use | can be used for the preparation of Western medicine compositions for the treatment of dyspepsia, Western medicine compositions for the treatment of anorexia, etc, is an intermediate in organic synthesis and pharmaceutical research and development. silibinin has the function of bacteriostasis and improving the detoxification ability of liver. for content determination/identification/pharmacological experiments. Pharmacological effects: antioxidant, anti-inflammatory, anti-tumor effects. |
biological activity | Isosilybin (Silymarin, Silybin B, Isosilybinin, Q-100795) is a kind of Silybin in milk thistle (S. marianum) flavanol found in fruit extract, has antioxidant and anticancer activity. Isosilybin inhibited CYP3A4 induction with an IC50 of 74 μm. |
Target | Value |
CYP3A4 (Cell-free assay) | 74 μM |