Name | Isatin |
Synonyms | Isatin Indole-2,3-dione 2,3-Indolinedione IRSOGLADINEMALEATE 1H-indole-2,3-dione Isatin, reagent grade ISATIN, TECHNICAL GRADE Isatin, synthesis grade ISATIN, PHARMACEUTICAL GRADE 2,3-DiketoindolineIndole-2,3-dione2,3-Indolinedione |
CAS | 91-56-5 |
EINECS | 202-077-8 |
InChI | InChI:1S/C8H5NO2/c10-7-5-3-1-2-4-6(5)9-8(7)11/h1-4H,(H,9,10,11) |
InChIKey | JXDYKVIHCLTXOP-UHFFFAOYSA-N |
Molecular Formula | C8H5NO2 |
Molar Mass | 147.13 |
Density | 1.3067 (rough estimate) |
Melting Point | 193-195 °C (dec.) (lit.) |
Boling Point | 267.22°C (rough estimate) |
Flash Point | 220 °C |
Water Solubility | Soluble in water (1.9 g/L at 20°C). |
Solubility | Soluble in hot ethanol, slightly soluble in ether, soluble in hot water, benzene, acetone, soluble in alkali metal hydroxide oxide. |
Vapor Presure | 0Pa at 25℃ |
Appearance | Orange red single residual prism crystal |
Color | Orange |
Merck | 14,5104 |
BRN | 383659 |
pKa | 10.34±0.20(Predicted) |
PH | 7 (1.9g/l, H2O, 20℃) |
Storage Condition | Store below +30°C. |
Stability | Stable. Incompatible with strong acids. |
Refractive Index | 1.4700 (estimate) |
MDL | MFCD00005718 |
Physical and Chemical Properties | Appearance: yellow-red crystal Melting Point: 201-204 ℃ |
Use | For the preparation of vat dyes and drugs; Used as reagents for the determination of ketone and thiophene |
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S24/25 - Avoid contact with skin and eyes. |
UN IDs | 2811 |
WGK Germany | 1 |
RTECS | NL7873000 |
TSCA | Yes |
HS Code | 29337900 |
Hazard Class | 6.1(b) |
Packing Group | III |
Reference Show more | 1. Zhang Yiming, Wan Hui Hua, Su Yong, Lu Meng, Yang Wei, Zhi Junwen. Effects of frostbite bluish on the contents of four indolyl derivatives in broad-sense postrinus plants [J]. Journal of Northwest Botany, 2020,40(11):1951-1958. 2. [IF = 4.162] Jiuling Deng et al."A Network Pharmacology-Based Investigation to the Pharmacodynamic Material Basis and Mechanisms of the Anti-coronary and Anti-Viral Effect of Isatis indigotica." Drug Des Dev Ther. 2021; 15: 3193-3206 |