Name | Irsogladine |
Synonyms | Gaslon Irsogladin 57381-26-7 Irsogladine IRSOGLADINE Irsogladine free base 2',5'-Dichlorobenzoguanamine 5-triazine-2,4-diamine,6-(2,5-dichlorophenyl)-3 2,4-diamino-6-(2,5-dichlorophenyl)-1,3,5-triazine 6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine 1,3,5-triazine-2,4-diamine, 6-(2,5-dichlorophenyl)- Irsogladine,2,4-DiaMino-6-(2,5-dichlorophenyl)-1,3,5-triazine |
CAS | 57381-26-7 |
InChI | InChI=1/C9H7Cl2N5/c10-4-1-2-6(11)5(3-4)7-14-8(12)16-9(13)15-7/h1-3H,(H4,12,13,14,15,16) |
Molecular Formula | C9H7Cl2N5 |
Molar Mass | 256.09 |
Density | 1.572 |
Melting Point | 268-269°C |
Boling Point | 552.2±60.0 °C(Predicted) |
Flash Point | 287.8°C |
Vapor Presure | 3.07E-12mmHg at 25°C |
pKa | 3.88±0.10(Predicted) |
Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
Refractive Index | 1.706 |
Physical and Chemical Properties | Colorless crystals from dioxane, melting point 268~269 ℃. Isogladine Maleate: C9H7C12N5? C4H4O4. [84504-69-8]. White or colorless crystal or crystalline powder, odorless, slightly bitter. Slightly soluble in methanol, ethanol, acetic acid or methyl acetate, very slightly soluble in ethyl acetate or ether, insoluble in chloroform or water. Melting point 205 °c (decomposition). Acute toxicity LD50 male and female mice, male and female rats (mg/kg):6035,5697,3898,2917 oral; 2841,3216,1600,1524 subcutaneous injection; 775,1006,558,545 intraperitoneal injection. |
Use | For the treatment of gastric ulcer |
colorless crystals from dioxane, melting point 268-269 °c.
2, 5-chlorotoluene was added to a 50% pyridine aqueous solution, potassium permanganate was slowly added with stirring, and the reaction was followed by treatment to obtain 2,5-= chlorobenzoic acid. 2,5-= chlorobenzoic acid, sulfamic acid and urea were heated together and treated to give 2,5-= chlorobenzonitrile. 2,5-= chlorobenzonitrile, cyanoguanidine, potassium hydroxide and ethylene glycol, stirred at 110 °c. After cooling, adding water, filtering, washing with water, recrystallization from methanol-Water, White isoradine is obtained, isoradine and maleic acid are refluxed in dioxane, cooling, filtering, washing with water, drying, recrystallization from anhydrous ethanol, white crystalline isoradine maleate was obtained.
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.905 ml | 19.524 ml | 39.049 ml |
5 mM | 0.781 ml | 3.905 ml | 7.81 ml |
10 mM | 0.39 ml | 1.952 ml | 3.905 ml |
5 mM | 0.078 ml | 0.39 ml | 0.781 ml |
Japan New Drug Corporation research and development, in 1989. For gastric ulcer disease. Gastric mucosal protective agents, by strengthening the combination of gastric mucosal epithelial cells, inhibit epithelial cell detachment, shedding and cell gap expansion, enhance the stability of the mucosal cells themselves, in order to play the role of mucosal defense, inhibition of harmful substances through the mucosa. Has anti-ulcer effect, for the treatment of gastric ulcer, can also be used to improve acute gastritis, acute exacerbation of chronic gastritis gastric mucosal lesions.
isopetadine maleate, male and female mice, male and female rats LDso(mg/kg): 6035,5697,3898,2917 by mouth; 2841,3216,1600,1524 subcutaneous injection; 775, 1006,558,545 intraperitoneal injection.