Name | Imidazole |
Synonyms | IMZ IMIDAZOLE GLYOXALIN IMINAZOLE Imidazole Glyoxaline 1,3-diazole 1,3-DIAZOLE 1H-IMIDAZOLE 1H-imidazole IMIDAZOLE BUFFER Imidazole Glyoxaline LABOTEST-BB LTBB001344 Imidazole, ULTROL Grade 1,3-DIAZA-2,4-CYCLOPENTADIENE |
CAS | 288-32-4 |
EINECS | 206-019-2 |
InChI | InChI=1/C3H4N2/c1-2-5-3-4-1/h1-3H,(H,4,5) |
InChIKey | RAXXELZNTBOGNW-UHFFFAOYSA-N |
Molecular Formula | C3H4N2 |
Molar Mass | 68.08 |
Density | 1.01g/mLat 20°C |
Melting Point | 88-91°C(lit.) |
Boling Point | 256°C(lit.) |
Flash Point | 293°F |
Water Solubility | 633 g/L (20 ºC) |
Solubility | H2O: 0.1M at20°C, clear, colorless |
Vapor Presure | <1 mm Hg ( 20 °C) |
Appearance | White Crystals |
Specific Gravity | 1.03 |
Color | white |
Odor | Amine like |
Maximum wavelength(λmax) | ['λ: 260 nm Amax: 0.10', , 'λ: 280 nm Amax: 0.10'] |
Merck | 14,4912 |
BRN | 103853 |
pKa | 6.953(at 25℃) |
PH | 9.5-11.0 (25℃, 50mg/mL in H2O) |
Storage Condition | Store below +30°C. |
Stability | Stable. Incompatible with acids, strong oxidizing agents. Protect from moisture. |
Sensitive | Hygroscopic |
Refractive Index | 1.4801 |
MDL | MFCD00005183 |
Physical and Chemical Properties | Characteristics of colorless prismatic crystals, weakly alkaline. melting point 90~91 ℃ boiling point 257 ℃ relative density 1.0303 refractive index 1.4801 flash point 145 ℃ solubility, ethanol, ether, chloroform, pyridine, benzene-soluble, insoluble in petroleum ether. |
Use | Used as raw materials and intermediates in organic synthesis for the preparation of drugs and pesticides |
Risk Codes | R36/38 - Irritating to eyes and skin. R63 - Possible risk of harm to the unborn child R34 - Causes burns R22 - Harmful if swallowed R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R61 - May cause harm to the unborn child |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S22 - Do not breathe dust. S36 - Wear suitable protective clothing. S27 - Take off immediately all contaminated clothing. S53 - Avoid exposure - obtain special instructions before use. |
UN IDs | UN 2923 8/PG 3 |
WGK Germany | 1 |
RTECS | NI3325000 |
TSCA | Yes |
HS Code | 29332990 |
Hazard Class | 8 |
Packing Group | III |
Toxicity | LD50 in mice (mg/kg): 610 i.p.; 1880 orally (Nishie) |
Raw Materials | Ammonium hydroxide Formaldehyde Glyoxal |
Downstream Products | clotrimazole crystalline Miconazole nitrate Econazole |
Reference Show more | 1. Gao Jing, Wang Nan, Guan Sijing, etc. Study on the signal mechanism of stomatal closure induced by Beauveria bassiana [J]. Shaanxi Agricultural Sciences, 2019, 065(005):72-75. 2. He, Tong, et al. "Dummy molecully imaged polymer-based microplate chemistry sensor for one-step detection of gross dies in egg." Food chemistry 288 (2019): 347-353.https:// doi.org/10.1016/j. Food Chem. 3/031, 2019 3. Jiang, Zu Qiang, et al. "Determination of Tetracyclines in Milk with a Molecularly Imprinted Polymer-Based Microtiter Chemiluminescence Sensor." Analytical Letters 52.8 (2019): 1315-1327.https://doi.org/10.1080/00032719.2018.1537282 4. Che, Haoqi, et al. "Exopolysaccharide from Streptococcus thermophilus as stabilizer in fermented dairy: Binding kinetics and interactions with casein of milk." International journal of biological macromolecules 140 (2019): 1018-1025.https://doi.org/10.1016 5. [IF=7.514] Tong He et al."Dummy molecularly imprinted polymer based microplate chemiluminescence sensor for one-step detection of Sudan dyes in egg."Food Chem. 2019 Aug;288:347 6. [IF=2.329] Zu Qiang Jiang et al."Determination of Tetracyclines in Milk with a Molecularly Imprinted Polymer-Based Microtiter Chemiluminescence Sensor."Anal Lett. 2019;52(8):1315-1327 7. [IF=2.329] Ming Xin Xu et al."Determination of β-Agonists in Porcine Urine by Molecularly Imprinted Polymer Based Chemiluminescence."Anal Lett. 2019;52(11):1771-1787 8. [IF=1.321] Xin-Ying Zhang et al."Molecularly Imprinted Polymer Based Chemiluminescence Method for Detection of Nitrofurans."Aust J Chem. 2019 Feb;72(5):375-382 9. [IF=5.909] Liwei Sun et al."Bi-functionalized ionic liquid-grafted mesoporous alumina: Synthesis, characterization and CO2/N2 selectivity."J Environ Chem Eng. 2021 Oct;9:105829 |
colorless rhombic crystals. Melting point 90-91 °c. Boiling point 257 ℃,165~168 ℃ (2.7kPa),138.2 ℃(1.6kPa). The relative density of 1.0303(101 deg C). Refractive index 1.4801 (101 degrees C). Flash point 145 °c. Soluble in water, ethanol, ether, chloroform, pyridine, benzene-soluble, very slightly soluble in petroleum ether. Weakly alkaline. With the high manganese acid aqueous solution to produce formic acid; And hydrogen peroxide to generate oxalic acid.
This product has the following two synthetic routes.
This product is mainly used as a curing agent for epoxy resin, and its dosage is 0.5% ~ 10% of epoxy resin. Imidazole is one of the main raw materials for producing anti-fungal drugs such as diclofenac, econazole, ketoconazole and clotrimazole. From imidazole and 2, 4-chloroacetophenone as the main raw material can be prepared by imazole, is an antifungal drug, is also widely used as fruit preservatives.