INDOMETHACIN MORPHOLINYLAMIDE
BML-190
CAS: 2854-32-2
Molecular Formula: C23H23ClN2O4
INDOMETHACIN MORPHOLINYLAMIDE - Names and Identifiers
INDOMETHACIN MORPHOLINYLAMIDE - Physico-chemical Properties
| Molecular Formula | C23H23ClN2O4 |
| Molar Mass | 426.89 |
| Density | 1.31 |
| Melting Point | 162.0-163.5 °C |
| Boling Point | 586.7±50.0 °C(Predicted) |
| Solubility | DMSO: >20mg/mL |
| Appearance | solid |
| Color | off-white |
| pKa | -0.97±0.20(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| In vitro study | BML-190 the selectivity of CB2 receptor is 50 times higher than that of CB1 receptor. In HEK-293 cells stably expressing human CB2 receptors, BML-190 enhanced Forskolin-stimulated cAMP accumulation. BML-190 reduces basal levels of inositol phosphate production in cells expressing the CB2 receptor. 10 M BML-190 reduced 38% of the accumulation of inositol phospholipids. BML-190 is an aminoalkylindole. BML-190 can produce at least 15 metabolites. BML-190 reduced LPS-induced NO and IL-6 production in a concentration-dependent manner. BML-190 also inhibited LPS-induced PGE2 production and COX-2 sensing. |
INDOMETHACIN MORPHOLINYLAMIDE - Risk and Safety
| WGK Germany | 3 |
INDOMETHACIN MORPHOLINYLAMIDE - Reference Information
| biological activity | BML-190 (IMMA) is a selective reverse agonist of cannabinoid CB2 receptor, Ki is 435 nM, which is 50 times more selective than acting on CB1 receptor. |
| target | TargetValue CB2 435 nM(Ki) |
| Target | Value |
| CB2 | 435 nM(Ki) |
| in vitro studies | BML-190 are 50 times more selective for CB2 receptors than for CB1 receptors. In HEK-293 cells stably expressing the human CB2 receptor, the cAMP accumulation stimulated by the BML-190 was enhanced. BML-190 decrease the basal level of inositol phosphate production in cells expressing the CB2 receptor. 10 μM BML-190 reduce 38% inositol phospholipid accumulation. BML-190 is an aminoalkyl indole. BML-190 can produce at least 15 metabolites. BML-190 reduced LPS-induced NO and IL-6 production in a concentration-dependent manner. BML-190 also inhibited LPS-induced PGE2 production and COX-2 induction. |
Last Update：2024-04-09 20:52:54
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Product Name: Indomethacin morpholinylamide; IMMA Visit Supplier Webpage Request for quotationCAS: 2854-32-2
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Product Name: BML-190 Visit Supplier Webpage Request for quotationCAS: 2854-32-2
Tel: +86-400-900-4166
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Mobile: +86-18621343501
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Tel: +86-18821248368
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Product Name: BML-190 Visit Supplier Webpage Request for quotation
CAS: 2854-32-2
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Email: 3008007409@qq.com
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CAS: 2854-32-2
Tel: 18301782025
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View History
INDOMETHACIN MORPHOLINYLAMIDE
Benzamide, N-[(2,4-dichlorophenyl)methoxy]-2,5-bis(2,2,2-trifluoroethoxy)-
Z-L-GLUTAMIC ACID GAMMA-T-BUTYL ESTER-ALPHA-4-NITROPHENYL ESTER
5-乙酰基-2-溴苯甲酸甲酯
FMOC-1-氨基茚满-1-羧酸
(1R,2R)-2-氨基环己烷-1-羧酸甲酯
1,4-二氧螺环[4,5]癸烷
4-哌啶甲脒
冰染重氮组分 36
[ala92]-p16 fragment 84-103
Benzamide, N-[(2,4-dichlorophenyl)methoxy]-2,5-bis(2,2,2-trifluoroethoxy)-
Z-L-GLUTAMIC ACID GAMMA-T-BUTYL ESTER-ALPHA-4-NITROPHENYL ESTER
5-乙酰基-2-溴苯甲酸甲酯
FMOC-1-氨基茚满-1-羧酸
(1R,2R)-2-氨基环己烷-1-羧酸甲酯
1,4-二氧螺环[4,5]癸烷
4-哌啶甲脒
冰染重氮组分 36
[ala92]-p16 fragment 84-103