Name | Decloxizine hydrochloride |
Synonyms | Autokar Rescupal Decloxizine Hcl DECLOXIZINE DIHCL Hydroxydiethylphenamine Decloxizine hydrochloride Hydroxyzine EP Impurity B 2-[2-(4-benzhydrylpiperazin-1-yl)ethoxy]ethanol,dihydrochloride 2-[2-[4-(DiphenylMethyl)-1-piperazinyl]ethoxy]ethanol Hydrochloride 2-(2-(4-(Diphenylmethyl)-1-piperazinyl)ethoxy)ethanol dihydrochloride 2-{2-[4-(diphenylmethyl)piperazin-1-yl]ethoxy}ethanol dihydrochloride Ethanol, 2-(2-(4-(diphenylmethyl)-1-piperazinyl)ethoxy)-, dihydrochloride 1-[2-(2-Hydroxyethoxy)ethyl]-4-α-phenylbenzyldiethylenediaMine Dihydrochloride 1-[2-(2-Hydroxyethoxy)ethyl]-4-alpha-phenylbenzyldiethylenediamine dihydrochloride |
CAS | 13073-96-6 |
EINECS | 1312995-182-4 |
InChI | InChI=1/C21H28N2O2.2ClH/c24-16-18-25-17-15-22-11-13-23(14-12-22)21(19-7-3-1-4-8-19)20-9-5-2-6-10-20;;/h1-10,21,24H,11-18H2;2*1H |
Molecular Formula | C21H28N2O2.2ClH |
Molar Mass | 413.386 |
Melting Point | 198 - 200°C |
Boling Point | 472.4°C at 760 mmHg |
Flash Point | 239.5°C |
Solubility | Chloroform (Slightly), Methanol (Slightly), Water (Slightly) |
Vapor Presure | 9.93E-10mmHg at 25°C |
Appearance | Solid |
Color | White to Off-White |
Storage Condition | Inert atmosphere,Room Temperature |
Stability | Hygroscopic |
Use | Antiallergic drugs, mainly used in the treatment of bronchial asthma and asthmatic bronchitis |
This product is 2-[2-[4-(diphenylmethyl)-l-piperazinyl] ethoxy] Ethanol dihydrochloride. Calculated as dry product, containing C21H28N202 • 2HC1 shall not be less than 98.5%.
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.419 ml | 12.095 ml | 24.191 ml |
5 mM | 0.484 ml | 2.419 ml | 4.838 ml |
10 mM | 0.242 ml | 1.21 ml | 2.419 ml |
5 mM | 0.048 ml | 0.242 ml | 0.484 ml |
take this product, add mobile phase to dissolve and dilute to make a solution containing about 0.8mg per 1 ml, as a test solution | Precision children take good 14, as a control solution, the mobile phase was diluted to the solution contained in 1 ml. According to the determination of high performance liquid chromatography (General 0512), with eighteen alkyl silane bonded silica gel as filler, methanol-water-triethylamine (42:58:0.5)(PH adjusted to 3.0 with phosphoric acid) as mobile phase, the detection wavelength was 225nm. The number of theoretical plates shall not be less than 4000 calculated by the peak of hydrochloric acid deschloroxazine, and the separation degree between the peak of hydrochloric acid deschloroxazine and the adjacent impurity peaks shall meet the requirements. 10 u1 of the test solution and the control solution were respectively injected into the human liquid chromatograph, and the chromatogram was recorded to 3.5 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than 0.5 times (0.5%) the area of the main peak of the control solution, and the sum of the areas of each impurity peak shall not be greater than the area of the main peak of the control solution (1.0%).
take this product, dry to constant weight at 105°C, weight loss shall not exceed 3.0% (General rule 0831).
not more than 0.15% (General rule 0841).
take 0.50g of this product, add a little water to dissolve it, add 2ml of dilute acetic acid, dilute it with water to 25ml, and check it according to law (General rule 0821 first law), containing no more than 20 parts per million of heavy metals.
take this product about 0.15g, precision weighing, add glacial acetic acid 15ml dissolved, add mercury acetate test solution 5ml and crystal violet indicator solution 1 drop, with high gas acid titration solution (O. 1 mol/L) titration to a blue color of the solution, and the results of the titration were corrected by a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 20.67mg of C21H28N202 · 2HC1.
antihistamines.
light shielding, sealed storage.
This product contains hydrochloric acid chlorine hydroxyzine (C21H28N202 • 2HC1) should be 90.0% ~ 110.0% of the label.
This product is sugar-coated tablets, White after removing the coating; Easy moisture absorption.
Take 20 tablets of this product, precision weighing, fine grinding, precision weighing take appropriate amount (about equivalent to hydrochloric acid chloro hydroxyzine 0.lg), put in a 100ml measuring flask, add 0.1 mol/L hydrochloric acid solution appropriate amount, shake to dissolve hydrochloric acid degassed hydroxyzine and use 0. Dilute 1 mol/L hydrochloric acid solution to the scale, shake well, filter, take 2ml of continuous filtrate accurately, put it in a 100ml measuring flask, use 0. Dilute 1 mol/L hydrochloric acid solution to the scale, shake well, as the test solution, according to UV-visible spectrophotometry (General 0401), at the wavelength of 224nm absorbance; take another hydrochloric acid to the chlorine hydroxyzine control, precision weighing, add 0.lmol/L hydrochloric acid solution is dissolved and quantitatively diluted to make a solution containing about 20ug per lml, which is determined and calculated by the same method.
Same as deschloroxazine hydrochloride.
(l)25mg (2)50mg
light shielding, sealed storage.