HARMINE HYDROCHLORIDE
Harmine Hydrochloride
CAS: 343-27-1
Molecular Formula: C13H13ClN2O
HARMINE HYDROCHLORIDE - Names and Identifiers
HARMINE HYDROCHLORIDE - Physico-chemical Properties
| Molecular Formula | C13H13ClN2O |
| Molar Mass | 248.71 |
| Melting Point | 265-270°C |
| Boling Point | 421.4°Cat760mmHg |
| Solubility | Soluble in water, insoluble in petroleum ether and chloroform. |
| Appearance | Yellow solid |
| Color | off-white to pale green |
| Merck | 14,4616 |
| Storage Condition | 2-8°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months. |
| MDL | MFCD00012641 |
| Physical and Chemical Properties | Yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Peganum harma. |
| In vitro study | Harmine inhibits tau phosphorylation by DYRK1A by selected DANDYs, with an IC 50 of 190 nM. Harmine negatively regulates homologous recombination (HR) by interfering Rad51 recruitment, resulting in severe cytotoxicity in hepatoma cells. Furthermore, NHEJ inhibitor Nu7441 markedly sensitizes Hep3B cells to the anti-proliferative effects of Harmine. |
| In vivo study | It is shown that brain water content is significantly increased in the TBI group. Treatment with Harmine significantly reduces the tissue water content at 1, 3 and 5 days, compared with the TBI group. Harmine treatment significantly reduces the escape latency at 3 and 5 days, compared with the TBI group. Post-TBI administration of Harmine significantly improves the motor function recovery of the rats at 1, 3 and 5 days following TBI, compared with the TBI group without Harmine treatment. The neuronal survival rate in the Harmine-treated group is significantly increased, compared with the TBI group. Administration of Harmine results in marked elevation in the expression of GLT-1, compared with the TBI group. The administration of Harmine significantly reduces the expression of caspase 3, compared with the TBI group. |
HARMINE HYDROCHLORIDE - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R40 - Limited evidence of a carcinogenic effect |
| Safety Description | S22 - Do not breathe dust. S36 - Wear suitable protective clothing. |
| UN IDs | 1544 |
| WGK Germany | 3 |
| RTECS | MG9450000 |
| HS Code | 29339900 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
HARMINE HYDROCHLORIDE - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| biological activity | Harmine (Telepathine) is a fluorescent harmala alkaloid belonging to the β-carboline family of compounds, it is a competitive inhibitor of the ATP binding of the kinase pocket of DYRK1A with high cell permeability, and has an IC50 value about 60-fold higher than that of dyrk2. Harmine can also inhibit monoamine oxides (MAOs) and cdc-like kinases (CLKs). The Ki value for Harmine's inhibition of 5-HT2A serotin receptor was 397 nM. |
| Target | Value |
| DYRK1A (Cell-free assay) | 33 nM |
| MNB (Cell-free assay) | 149 nM |
| DYRK1B (Cell-free assay) | 166 nM |
| DYRK2 (Cell-free assay) | 1.9 μM |
| Use | harmine hydrochloride has anti-tumor effect. for content determination/identification/pharmacological experiments. Pharmacological Efficacy: bactericidal, antipruritic, anti-psoriasis effect, anti-tumor effect. |
| category | toxic substances |
| toxicity grade | high toxicity |
| Acute toxicity | intravenous-mouse LD50: 38 mg/kg |
| flammability hazard characteristics | flammable, combustion decomposition of toxic chloride, nitrogen oxide gas |
| storage and transportation characteristics | The warehouse is low temperature, ventilated and dry, and stored separately from food raw materials |
| fire extinguishing agent | water, carbon dioxide, foam, sand |
Last Update：2024-04-09 02:00:12
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View History
HARMINE HYDROCHLORIDE
葡萄糖酸钙(源头工厂)
Spiro[6H-cyclopenta[b]pyridine-6,3'-[3H]pyrrolo[2,3-b]pyridine]-3-carboxylic acid, 1',2',5,7-tetrahydro-2'-oxo-
ETHYL 1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-5-METHYL-1H-PYRAZOLE-4-CARBOXYLATE
Piperidine, 3-[4-(methylthio)phenyl]-
20(S)-Hydroxy Prednisolone-d4
ACTH (4-7)
ETHYL N-(2-[2-(3-CHLOROPHENYL)HYDRAZONO]-2-CYANOACETYL)CARBAMATE
2-(methylthio)pyridin-3-amine hydrochloride
2-{[(1-ethylpyrrolidin-2-yl)methyl]amino}-N-(3-methoxypropyl)propanamide
葡萄糖酸钙(源头工厂)
Spiro[6H-cyclopenta[b]pyridine-6,3'-[3H]pyrrolo[2,3-b]pyridine]-3-carboxylic acid, 1',2',5,7-tetrahydro-2'-oxo-
ETHYL 1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-5-METHYL-1H-PYRAZOLE-4-CARBOXYLATE
Piperidine, 3-[4-(methylthio)phenyl]-
20(S)-Hydroxy Prednisolone-d4
ACTH (4-7)
ETHYL N-(2-[2-(3-CHLOROPHENYL)HYDRAZONO]-2-CYANOACETYL)CARBAMATE
2-(methylthio)pyridin-3-amine hydrochloride
2-{[(1-ethylpyrrolidin-2-yl)methyl]amino}-N-(3-methoxypropyl)propanamide