Guanosine, 7,8-dihydro-8-oxo-7-(2-propenyl)-
7-Allyl-7 8-Dihydro-8-Oxoguanosine
CAS: 121288-39-9
Molecular Formula: C13H17N5O6
Guanosine, 7,8-dihydro-8-oxo-7-(2-propenyl)- - Names and Identifiers
Guanosine, 7,8-dihydro-8-oxo-7-(2-propenyl)- - Physico-chemical Properties
| Molecular Formula | C13H17N5O6 |
| Molar Mass | 339.3 |
| Density | 1.92±0.1 g/cm3(Predicted) |
| Melting Point | 227-230°C(lit.) |
| Solubility | Soluble in DMSO (up to 25 mg/ml). |
| Appearance | White to off-white solid. |
| Color | White |
| pKa | 10.29±0.20(Predicted) |
| Storage Condition | Desiccate at +4°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| In vitro study | Loxoribine induces maturation of human monocyte-derived dendritic cells DCs and stimulates their Th-1- and Th-17-polarizing capability. Loxoribine (250 μM; 48 hours) stimulates maturation of MoDCs as shown by up-regulation of CD80, CD83, CD40, CD54 and CCR7. loxoribine activates cells of the innate immune system selectively via the Toll-like receptor (TLR) 7/MyD88-dependent signaling pathway. |
Guanosine, 7,8-dihydro-8-oxo-7-(2-propenyl)- - Risk and Safety
| WGK Germany | 3 |
| HS Code | 29349990 |
Guanosine, 7,8-dihydro-8-oxo-7-(2-propenyl)- - References
| Use | rosolbine acts as a synthetic adjuvant in anti-tumor response. |
| biological activity | Loxoribine (7-Allyl-8-oxoguanosine) is a guanosine analog with antiviral and antitumor activity. Loxoribine is an orally bioavailable, selective TLR7 agonist. |
| Target | TLR7 |
| Animal Model: | 8-12 weeks male CBA/J mice |
| Dosage: | 2 mg |
| Administration: | Subcutaneous or intravenous injection |
| Result: | activates murine natural killer (NK) cells in vivo. |
Last Update：2024-04-10 22:29:15
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