Gliadin p31-43
L-Tyrosine, L-leucylglycyl-L-glutaminyl-L-glutaminyl-L-glutaminyl-L-prolyl-L-phenylalanyl-L-prolyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-prolyl-
CAS: 176326-01-5
Molecular Formula: C71H102N18O20
Gliadin p31-43 - Names and Identifiers
Gliadin p31-43 - Physico-chemical Properties
| Molecular Formula | C71H102N18O20 |
| Molar Mass | 1527.68 |
| In vitro study | Gliadin p31-43 (100 μg/mL; 30 minutes-6 hours) treatment induces the MyD88/TLR7 complexes, and activates downstream signalling by activating MAPKs, ERK, JNK and p38). Gliadin p31-43 increases the levels of the phosphorylated forms of pY-ERK, JNK (pY-JNK) and p38 (pY-p38). Gliadin p31-43 treatment increases NF-κB phosphorylation in CaCo-2 cells from 0.45 in control cells to 0.86. Gliadin p31-43 treatment induces a significant increase in levels of the MxA protein. The levels of the IFN-α 7 and 17 mRNAs are also analysed after Gliadin p31-43 treatment. In CaCo-2 cells, Gliadin p31-43 localizes to the early endosomes and delays vesicular trafficking. Gliadin p31-43 interferes with the correct localization of the growth factor regulated tyrosine kinase substrate (HRS) to early endosomes, delaying the maturation of the endocytic vesicles. Western Blot Analysis Cell Line: CaCo-2 cells Concentration: 100 μg/mL Incubation Time: 30 minutes, 3 hours, 6 hours Result: Showed the increase in formation of the MyD88/TLR7 complex, and increased in the level of TLR7. |
| In vivo study | Gliadin p31-43 (10 μg; intraluminally injection) shows a sequence-specific spontaneous ability to form structured oligomers and aggregates in vitro and induced activation of the apoptosis-associated speck-like (ASC) complex. The increment of IL-1β indicates the activation of the inflammasome caspase-1 pathway in the small intestine mucosa by oral administration of Gliadin p31-43 (20 μg) in wild type C57Bl/6 mice. Gliadin p31-43 has an intrinsic propensity to form oligomers which trigger the NLRP3 inflammasome. |
Supplier List
Spot supply
Product Name: Gliadin p31-43 Visit Supplier Webpage Request for quotationCAS: 176326-01-5
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Gliadin p31-43 Visit Supplier Webpage Request for quotationCAS: 176326-01-5
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
View History
Gliadin p31-43
39931-63-0
ethylidene di(acetate)
59983-39-0
(E/Z)-SIB-1893
34724-82-8
1-chloro-4-bromobutane
3-allyl-5-(1-ethyl-6-methyl-2(1H)-quinolinylidene)-2-(1-methyl-5-oxo-3-phenyl-2-thioxo-4-imidazolidinylidene)-1,3-thiazolidin-4-one
2,4-Benzodioxepin, 3-(1,1-dimethylethyl)-1,5-dihydro-1,1-dimethyl-
353537-92-5
39931-63-0
ethylidene di(acetate)
59983-39-0
(E/Z)-SIB-1893
34724-82-8
1-chloro-4-bromobutane
3-allyl-5-(1-ethyl-6-methyl-2(1H)-quinolinylidene)-2-(1-methyl-5-oxo-3-phenyl-2-thioxo-4-imidazolidinylidene)-1,3-thiazolidin-4-one
2,4-Benzodioxepin, 3-(1,1-dimethylethyl)-1,5-dihydro-1,1-dimethyl-
353537-92-5