Gatifloxacin formic acid ethyl ester
Gatifloxacin sesquihydrate
CAS: 180200-66-2
Molecular Formula: C19H24FN3O5
Gatifloxacin formic acid ethyl ester - Names and Identifiers
Gatifloxacin formic acid ethyl ester - Physico-chemical Properties
| Molecular Formula | C19H24FN3O5 |
| Molar Mass | 393.42 |
| Boling Point | 684℃ |
| Solubility | Soluble in 1N NaOH at 10mg/ml |
| Appearance | neat |
| BRN | 14390028 |
| Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
| In vitro study | Gatifloxacin sesquihydrate is against S. aureus MS5935 topoisomerase IV, E. coli NIHJ JC-2 DNA gyrase and HeLa cell topoisomerase II with IC 50 values of 13.8 μg/ml, 0.109 μg/ml, and 265 μg/ml, respectively.Gatifloxacin sesquihydrate is against S. aureus MS5935 topoisomerase IV, E. coli NIHJ JC-2 DNA gyrase and HeLa cell topoisomerase II with MIC values of 0.05 μg/ml, 0.0063 μg/ml, and 122 μg/ml, respectively.Gatifloxacin sesquihydrate exhibits antibacterial activities for wild-type strains (MS5935, MS5952, MR5867 and MR6009) the first-, second-, third-, and fourth-step mutants with MIC values of 0.05 to 0.10 μg/ml, 0.20 μg/ml, 1.56 to 3.13 μg/ml, 1.56 to 6.25 μg/ml, and 50 to 200 μg/ml, respectively. Gatifloxacin sesquihydrate displays the most potent activity against the second- and third-step mutants (MS5952, MR5867 and MR6009) except for the second-step mutant of strain MS5935.Gatifloxacin sesquihydrate has potent activity against norA transformant NY12 (MIC, 0.39 μg/ml).Gatifloxacin sesquihydrate (20-100 μM; 72 hours) significantly decreases insulin content to 60% at Day 1, and continues to be reduced to 50.1% and 44.7% at Day 3 by 20 μM and 100 μM Gatifloxacin sesquihydrate, respectively. |
Gatifloxacin formic acid ethyl ester - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | 36/37 - Wear suitable protective clothing and gloves. |
| WGK Germany | 1 |
| RTECS | VB1983600 |
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Product Name: 1-Cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid sesquihydrate Visit Supplier Webpage Request for quotationCAS: 180200-66-2
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View History
Gatifloxacin formic acid ethyl ester
2-FLUORO-4-PYRROLIDIN-1-YL-BENZALDEHYDE
LS-136974
9,10-Anthracenedione, 1-hydroxy-4-[(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)oxy]-
1001648-65-2
Butanamide, N-(4-amino-2-chlorophenyl)-3-methyl-
4,8-Dichloroquinoline-3-carboxylic acid ethyl ester
1-(5-Methyl-isoxazol-3-yl)-cyclopropanecarboxylic acid
Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-6-(1-methylcyclopropyl)-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-
Quinoline, 1-ethyl-1,2,3,4-tetrahydro-7-(trifluoromethyl)-
2-FLUORO-4-PYRROLIDIN-1-YL-BENZALDEHYDE
LS-136974
9,10-Anthracenedione, 1-hydroxy-4-[(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)oxy]-
1001648-65-2
Butanamide, N-(4-amino-2-chlorophenyl)-3-methyl-
4,8-Dichloroquinoline-3-carboxylic acid ethyl ester
1-(5-Methyl-isoxazol-3-yl)-cyclopropanecarboxylic acid
Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-6-(1-methylcyclopropyl)-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-
Quinoline, 1-ethyl-1,2,3,4-tetrahydro-7-(trifluoromethyl)-