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Ganglioside, asialo GM1

Asialoganglioside GM1

CAS: 71012-19-6

Molecular Formula: C62H114N2O23

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Ganglioside, asialo GM1 - Names and Identifiers

Name Asialoganglioside GM1
Synonyms GM1
asialo
chromium
Asialo GM1
Ganglioside GM1
GA1-GANGLIOSIDE
Asialo GM1 glycolipid
Asialoganglioside GM1
Ceramide tetrahexoside
Asialo GM1 ganglioside
GANGLIOSIDE GM1, ASIALO
Ganglioside, asialo GM1
Gangliotetraosyl ceramide
Ganglio-N-tetraosylceramide
Monosialotetrahexosylganglioside
Ganglioside GA1, de(N-acetyl-alpha-neuraminosyl)-(2-3B)
GAL-BETA1,3GALNAC-BETA1,4GAL-BETA1,4GLC-BETA1,1' CERAMIDE
GAL-BETA1,3GALNAC-BETA1,4GAL-BETA1,4GLC-BETA1,1' CERAMIDE, HUMAN
N-[(2S,3R,4E)-1-(beta-D-glucopyranosyloxy)-3-hydroxyoctadec-4-en-2-yl]octadecanamide
N-{(1S,2R,3E)-1-[(beta-D-glucopyranosyloxy)methyl]-2-hydroxyheptadec-3-en-1-yl}docosanamide
N-{(1S,2R,3E)-1-[(beta-D-glucopyranosyloxy)methyl]-2-hydroxyheptadec-3-en-1-yl}tetracosanamide
N-((2S,3R,E)-1-((2R,3R,4R,5S,6R)-5-((2S,3R,4R,5R,6R)-5-((2S,3R,4R,5R,6R)-3-ethanamido-5-hydroxy-6-(hydroxymethyl)-4-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)tetrahydro-2H-pyran-2-yloxy)-3,4-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)-3,4-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)-3-hydroxyoctadec-4-en-2-yl)icosanamide
N-((2S,3R,E)-1-((2R,3R,4R,5S,6R)-5-((2S,3R,4R,5R,6R)-5-((2S,3R,4R,5R,6R)-3-ethanamido-5-hydroxy-6-(hydroxymethyl)-4-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)tetrahydro-2H-pyran-2-yloxy)-3,4-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)-3,4-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)-3-hydroxyoctadec-4-en-2-yl)docosanamide
(2S,4R,5S,6S)-2-[(2S,3R,4R,5S,6R)-5-[(2S,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-2-[(2R,3S,4R,5R,6R)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(E)-3-hydroxy-2-(octadecanoylamino)octadec-4-enoxy]tetrahydropyran-3-yl]oxy-3-hydroxy-6-(hydroxymethyl)tetrahydropyran-4-yl]oxy-5-amino-6-[3-[(2R,4R,5S,6S)-5-amino-2-carboxy-4-hydroxy-6-(1,2,3-trihydroxypropyl)tetrahydropyran-2-yl]oxy-1,2-dihydroxy-propyl]-4-hydroxy-tetrahydropyran-2-carboxylic acid
CAS 71012-19-6
EINECS 231-157-5
InChI InChI=1/C62H114N2O23/c1-4-6-8-10-12-14-16-18-19-21-23-25-27-29-31-33-46(71)64-40(41(70)32-30-28-26-24-22-20-17-15-13-11-9-7-5-2)38-80-60-54(78)51(75)57(44(36-67)83-60)86-62-55(79)52(76)56(45(37-68)84-62)85-59-47(63-39(3)69)58(49(73)43(35-66)81-59)87-61-53(77)50(74)48(72)42(34-65)82-61/h30,32,40-45,47-62,65-68,70,72-79H,4-29,31,33-38H2,1-3H3,(H,63,69)(H,64,71)/b32-30+/t40?,41?,42-,43-,44-,45-,47-,48+,49+,50+,51-,52-,53-,54-,55-,56+,57-,58-,59+,60?,61+,62+/m1/s1

Ganglioside, asialo GM1 - Physico-chemical Properties

Molecular FormulaC62H114N2O23
Molar Mass1255.56816
Density1.28g/cm3
Boling Point1302°C at 760 mmHg
Flash Point741.2°C
Vapor Presure0mmHg at 25°C
Appearancelyophilized powder
Storage Condition−20°C
Refractive Index1.57
Physical and Chemical PropertiesGangliosides are sialic acid containing sugar sphingolipids, exists in the mammalian cell membrane, the content of the nervous system is particularly rich, is a component of the nerve cell membrane, in neurogenesis, growth, it plays an essential role in the process of differentiation, and is also very important for nerve repair after injury. It can promote nerve regeneration, promote nerve axon growth and synapse formation, and restore innervation; improve nerve conduction, promote the recovery of brain electrical activity and other nerve electrophysiological indexes; Protect the cell membrane, promote the recovery of the enzyme activity of the cell membrane and other effects
GM1 is one of the most important gangliosides, plays an important role in the treatment of lesions of the central nervous system. GM1 not only has the joint action of the above gangliosides, but also can maintain the activity of Na -K-ATPase and Ca2 -Mg2-ATPase on the central nerve cell membrane, it plays a role in maintaining the balance of ions inside and outside the cell, reducing the edema of nerve cells and preventing the accumulation of intracellular Ca2. GM1 can resist the neurotoxicity of excitatory amino acids, reduce the damage of free radicals to nerve cells, etc. Therefore, GM1 has the function of promoting nerve remodeling (nerve remodeling, neural plasticity, Neuroplasticity), that is, by promoting the improvement of various forms, biochemistry, histochemistry, neurophysiology, ultimately, nerve repair can be accelerated and the original nerve function can be restored to the greatest extent.
GM1 can promote the recovery of nerve function and promote nerve remodeling after central nervous system injury caused by various reasons. Experiments show that GM1 can promote the recovery of nerve cells and protect cells in vascular brain injury and traumatic brain injury.
UseFor the treatment of vascular or traumatic central nervous system injuries; Parkinson's disease.

Ganglioside, asialo GM1 - Risk and Safety

Safety DescriptionS22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
WGK Germany3
FLUKA BRAND F CODES10

Ganglioside, asialo GM1 - Introduction

Asialoganglioside GM1(Asialoganglioside GM1) is a complex glycolipid that is a common lipid molecule in the nervous system. It consists of phospholipids and sugar molecules and has a unique chemical structure.

Asialoganglioside GM1GM1 plays an important biological role in the nervous system. It is involved in the signal transduction process between nerve cells and regulates the development, proliferation and survival of brain cells. In addition, GM1 is also involved in the process of cell recognition and cell adhesion.

The main purpose of using the Asialoganglioside GM1GM1 is to trigger the growth and recovery of neurons in research. GM1 can be used as a compound to promote neuronal regeneration and repair, and has potential application value in the study of neurodegenerative diseases and nervous system injury.

The preparation methods of Asialoganglioside GM1GM1 mainly include extraction and purification from animal tissues, chemical synthesis and genetic engineering technology. The most common of these is through extraction from animal tissue such as bovine brain and subsequent purification by various chemical methods.

Regarding the safety of Asialoganglioside GM1GM1, it is generally relatively safe under proper use. However, more research is needed for specific uses and dosages. Use should pay attention to comply with the correct experimental procedures, and strictly in accordance with the requirements of laboratory safety operation. Safety assessment and appropriate toxicity testing should be performed prior to use.
Last Update:2024-04-09 21:32:43
Ganglioside, asialo GM1
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CAS: 71012-19-6
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SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
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CAS: 71012-19-6
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CAS: 71012-19-6
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View History
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