Fmoc-D-β-萘基丙氨酸
(R)-N-FMOC-2-Naphthylalanine
CAS: 138774-94-4
Molecular Formula: C28H23NO4
Fmoc-D-β-萘基丙氨酸 - Names and Identifiers
| Name | (R)-N-FMOC-2-Naphthylalanine |
| Synonyms | Fmoc-D-2l-OH Fmoc-D-2-Nal-OH (R)-N-FMOC-2-NAPHTHYLALANINE (R)-N-FMOC-2-Naphthylalanine Fmoc-D-3-(2-Naphthyl)-alanine Fmoc-3-(2-Naphthyl)-D-alanine (9H-Fluoren-9-yl)MethOxy]Carbonyl D-2-Nal-OH 2-Naphthalenepropanoicacid, a-[[(9H-fluoren-9-ylMethoxy)carbonyl]aMino]-,(aR)- (R)-2-((((9H-Fluoren-9-yl)Methoxy)carbonyl)aMino)-3-(naphthalen-2-yl)propanoic acid |
| CAS | 138774-94-4 |
| InChI | InChI=1/C28H23NO4/c30-27(31)26(16-18-13-14-19-7-1-2-8-20(19)15-18)29-28(32)33-17-25-23-11-5-3-9-21(23)22-10-4-6-12-24(22)25/h1-15,25-26H,16-17H2,(H,29,32)(H,30,31)/t26-/m1/s1 |
Fmoc-D-β-萘基丙氨酸 - Physico-chemical Properties
| Molecular Formula | C28H23NO4 |
| Molar Mass | 437.49 |
| Density | 1.2227 (rough estimate) |
| Melting Point | 191 °C |
| Boling Point | 549.64°C (rough estimate) |
| Flash Point | 371.6°C |
| Water Solubility | Slightly soluble in water. |
| Solubility | Chloroform (Slightly, Sonicated), DMF (Sparingly, Sonicated), DMSO (Slightly), M |
| Vapor Presure | 4.95E-20mmHg at 25°C |
| Appearance | White to beige powder |
| Color | White to Off-White |
| BRN | 7864489 |
| pKa | 3.77±0.30(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.6290 (estimate) |
| MDL | MFCD00077044 |
| Use | An Fmoc-protected alanine derivative |
Fmoc-D-β-萘基丙氨酸 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Safety Description | S24/25 - Avoid contact with skin and eyes. S22 - Do not breathe dust. |
| WGK Germany | 3 |
| HS Code | 29242990 |
| Hazard Class | IRRITANT |
Fmoc-D-β-萘基丙氨酸 - Introduction
Fmoc-D-β-naphthylalanine is a chiral amino acid compound. Its properties are as follows:
1. Appearance: white or almost white crystalline powder.
2. Solubility: Soluble in organic solvents such as dimethyl sulfoxide (DMSO), dichloromethane and ammonia, but insoluble in water.
3. Melting point: about 118-122°C.
Fmoc-D-β-naphthylalanine is commonly used as a building block for peptide chains in solid phase synthesis (SPPS). It can be synthesized in solid phase as an active ester (support structure) or as an amino-functionalized group (support free amine). In addition, it can also be used to prepare peptide or small molecule fluorescent probes.
The preparation method of Fmoc-D-β-naphthylalanine generally adopts an organic synthesis method. It can be synthesized by attaching an Fmoc protecting group to D-β-naphthylalanine. Specifically, D-β-naphthylalanine is first reacted with Fmoc-Cl (difluoroformamide protecting group) to produce Fmoc-D-β-naphthylalanine.
Please note the following points regarding its safety information:
1. Fmoc-D-β-naphthylalanine may be irritating to eyes, skin and respiratory system. Wash thoroughly after contact.
2. When using or handling Fmoc-D-beta-naphthylalanine, wear appropriate personal protective equipment, such as laboratory gloves, protective glasses, and protective masks.
3. In the storage and handling of the compound, should avoid fire and high temperature.
4. The specific safety operation should be carried out according to the specific application and relevant safety information. It is recommended to read the relevant safety data form and follow the laboratory operation procedures. In general, it is safer to operate in an experienced chemical laboratory.
1. Appearance: white or almost white crystalline powder.
2. Solubility: Soluble in organic solvents such as dimethyl sulfoxide (DMSO), dichloromethane and ammonia, but insoluble in water.
3. Melting point: about 118-122°C.
Fmoc-D-β-naphthylalanine is commonly used as a building block for peptide chains in solid phase synthesis (SPPS). It can be synthesized in solid phase as an active ester (support structure) or as an amino-functionalized group (support free amine). In addition, it can also be used to prepare peptide or small molecule fluorescent probes.
The preparation method of Fmoc-D-β-naphthylalanine generally adopts an organic synthesis method. It can be synthesized by attaching an Fmoc protecting group to D-β-naphthylalanine. Specifically, D-β-naphthylalanine is first reacted with Fmoc-Cl (difluoroformamide protecting group) to produce Fmoc-D-β-naphthylalanine.
Please note the following points regarding its safety information:
1. Fmoc-D-β-naphthylalanine may be irritating to eyes, skin and respiratory system. Wash thoroughly after contact.
2. When using or handling Fmoc-D-beta-naphthylalanine, wear appropriate personal protective equipment, such as laboratory gloves, protective glasses, and protective masks.
3. In the storage and handling of the compound, should avoid fire and high temperature.
4. The specific safety operation should be carried out according to the specific application and relevant safety information. It is recommended to read the relevant safety data form and follow the laboratory operation procedures. In general, it is safer to operate in an experienced chemical laboratory.
Last Update：2024-04-09 20:52:54
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View History
Fmoc-D-β-萘基丙氨酸
Pasireotide Impurity 6
对异丁基苯丙酮新戊基缩酮(布洛芬杂质)
N[3-[(4-氨基-6,7-二甲氧基-2-喹唑啉基)甲基氨基]丙基]四氢-2-呋喃甲酰胺
2-(四氢吡喃-4-基)肼基甲酸叔丁酯
Pasireotide Impurity 6
对异丁基苯丙酮新戊基缩酮(布洛芬杂质)
N[3-[(4-氨基-6,7-二甲氧基-2-喹唑啉基)甲基氨基]丙基]四氢-2-呋喃甲酰胺
2-(四氢吡喃-4-基)肼基甲酸叔丁酯