Fmoc-Asp(OtBu)-(Dmb)Gly-OH, abbreviated Fmoc-Asp(OtBu)-(Dmb)Gly-OH, is a compound with the following properties and uses:
Nature:
1. Chemical formula: C38H43N3O9
2. molecular weight: 673.78g/mol
3. Appearance: white solid
4. Solubility: Soluble in some organic solvents, such as dimethyl sulfoxide and dichloromethane
Use:
Fmoc-Asp(OtBu)-(Dmb)Gly-OH is mainly used for peptide synthesis and polypeptide synthesis in solid phase synthesis. It is commonly used as a protecting group or as an intermediate in peptide synthesis. This compound has a high stability, can protect the aspartic acid residue, and provide protection or modification when required.
Method:
The preparation of the Fmoc-Asp(OtBu)-(Dmb)Gly-OH is generally carried out by solid phase synthesis. The specific steps involve chemical reactions and purification steps, including the synthesis of Fmoc-aspartic acid, the synthesis of hydroxymethoxybenzylglycine, the synthesis of β-tert-butyl ester, the reaction intermediates of valeric anhydride and the final structural identification.
Safety Information:
1. Fmoc-Asp(OtBu)-(Dmb)Gly-OH are organic compounds and should be used and stored in accordance with chemical safety practices.
2. avoid contact with skin and eyes. If exposed, flush immediately with plenty of water and seek medical help.
3. Maintain a well-ventilated laboratory environment during use.
4. if accidentally inhaled or ingested, please seek medical treatment immediately.
5. During handling and storage, avoid contact with oxidants and strong acids to avoid chemical reactions.