Name | Farrerol |
Synonyms | FARREROL Farrerol CYRTPOTERINETIN CYRTOPTERINETIN 5,7-Dihydroxy-2-(4-hydroxyphenyl) 5,7,4'-TRIHYDROXY-6,8-DIMETHYLFLAVANONE 6,8-Dimethyl-4',5,7-Trihydroxyflavanone 6,8-DIMETHYL-4',5,7-TRIHYDROXYFLAVANONE 6,8-DIMETHYL-5,7,4'-TRIHYDROXYFLAVANONE 5,7-Dihydroxy-2-(4-hydroxyphenyl)-6,8-diMethylchroMan-4-one 5,7-dihydroxy-2-(4-hydroxyphenyl)-6,8-dimethyl-2,3-dihydro-4H-chromen-4-one (S)-2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6,8-dimethyl-4-benzopyrone (2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-6,8-dimethyl-2,3-dihydro-4H-chromen-4-one |
CAS | 24211-30-1 |
EINECS | 246-080-2 |
InChI | InChI=1/C17H16O5/c1-8-15(20)9(2)17-14(16(8)21)12(19)7-13(22-17)10-3-5-11(18)6-4-10/h3-6,13,18,20-21H,7H2,1-2H3/t13-/m0/s1 |
Molecular Formula | C17H16O5 |
Molar Mass | 300.31 |
Density | 1.39 |
Melting Point | 212-220 °C |
Boling Point | 583.0±50.0 °C(Predicted) |
Specific Rotation(α) | (c, 0.1 in MeOH) -23 |
Flash Point | 220℃ |
Solubility | Soluble in hot methanol, DMSO and other solvents, insoluble in petroleum ether, chloroform. |
Vapor Presure | 3.44E-14mmHg at 25°C |
Appearance | Beige powder |
Color | Pale Yellow |
pKa | 8.22±0.40(Predicted) |
Storage Condition | 2-8°C |
Refractive Index | 1.662 |
MDL | MFCD28347824 |
Physical and Chemical Properties | From cuckoo. |
In vitro study | Farrerol observably reduces the production of inflammatory mediators including IL-1β, IL-6, TNF-α, COX-2, and iNOS in LPS-induced RAW264.7 cells via suppressing AKT, ERK1/2, JNK1/2, and NF-κB p65 phosphorylation. Farrerol attenuates β-amyloid-induced oxidative stress and inflammation through Nrf2/Keap1 pathway in a microglia cell line. Farrerol inhibits angiogenesis through Akt/mTOR, Erk and Jak2/Stat3 signal pathway. Farrerol overcomes the invasiveness of lung squamous cell carcinoma cells by regulating the expression of inducers of epithelial mesenchymal transition. Farrerol ameliorates acetaminophen-induced hepatotoxicity via activation of Nrf2 and autophagy. |
In vivo study | Farrerol protects dopaminergic neurons in a rat model of lipopolysaccharide-induced Parkinson's disease by suppressing the activation of the AKT and NF-κB signaling pathways. |
HS Code | 29329990 |