Ethyl 6-amino-3-bromopyridine-2-carboxylate
Ethyl 6-amino-3-bromopyridine-2-carboxylate
CAS: 1214332-35-0
Molecular Formula: C8H9BrN2O2
Ethyl 6-amino-3-bromopyridine-2-carboxylate - Names and Identifiers
| Name | Ethyl 6-amino-3-bromopyridine-2-carboxylate |
| Synonyms | Ethyl 6-amino-3-bromopicolinate Ethyl 6-amino-3-bromopyridine-2-carboxylate 2-Pyridinecarboxylic acid, 6-amino-3-bromo-, ethyl ester |
| CAS | 1214332-35-0 |
| InChI | InChI=1S/C8H9BrN2O2/c1-2-13-8(12)7-5(9)3-4-6(10)11-7/h3-4H,2H2,1H3,(H2,10,11) |
Ethyl 6-amino-3-bromopyridine-2-carboxylate - Physico-chemical Properties
| Molecular Formula | C8H9BrN2O2 |
| Molar Mass | 245.07 |
| Density | 1.575±0.06 g/cm3(Predicted) |
| Boling Point | 343.9±37.0 °C(Predicted) |
| pKa | 1.17±0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
Ethyl 6-amino-3-bromopyridine-2-carboxylate - Introduction
Ethyl 6-amino-3-bromo-2-pyridinecarboxylate is an organic compound with the chemical formula C8H9BrN2O2. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: Ethyl 6-amino-3-bromo-2-pyridinecarboxylate is a colorless or pale yellow solid.
-Solubility: It can be dissolved in some organic solvents, such as alcohols, ethers and esters.
-Melting point: Its melting point is about 50-52°C.
-Stability: It is relatively stable under dry conditions.
Use:
Ethyl 6-amino -3-bromo -2-pyridine carboxylate has many applications in organic synthesis:
-It can be used as an intermediate in organic synthesis and used to synthesize other compounds;
-It can be used as a pharmaceutical intermediate for the preparation of some drugs.
Preparation Method:
There are two main methods for the preparation of ethyl 6-amino -3-bromo -2-pyridine carboxylate:
-Bromination of ethyl 6-amino-3-pyridinecarboxylate by reaction of ethyl 6-amino-3-pyridinecarboxylate with bromine to give ethyl 6-amino-3-bromo-2-pyridinecarboxylate.
-Through bromobenzonitrile reaction: 6-amino-3-pyridinecarboxylic acid ethyl ester is reacted with benzonitrile and copper chloride, and then brominated to obtain 6-amino-3-bromo-2-pyridinecarboxylic acid ethyl ester.
Safety Information:
- 6-amino -3-bromo -2-pyridine carboxylic acid ethyl ester in the preparation and use of the need to pay attention to protective measures, such as wearing protective glasses and gloves.
-It may cause irritation to the skin, eyes and respiratory tract, so contact and inhalation need to be avoided.
-When handling or handling the compound, try to control the emission of dust and solution to prevent environmental and health impacts.
-When storing, it should be kept in a dry, cool place, away from fire and oxidizing agents.
Nature:
-Appearance: Ethyl 6-amino-3-bromo-2-pyridinecarboxylate is a colorless or pale yellow solid.
-Solubility: It can be dissolved in some organic solvents, such as alcohols, ethers and esters.
-Melting point: Its melting point is about 50-52°C.
-Stability: It is relatively stable under dry conditions.
Use:
Ethyl 6-amino -3-bromo -2-pyridine carboxylate has many applications in organic synthesis:
-It can be used as an intermediate in organic synthesis and used to synthesize other compounds;
-It can be used as a pharmaceutical intermediate for the preparation of some drugs.
Preparation Method:
There are two main methods for the preparation of ethyl 6-amino -3-bromo -2-pyridine carboxylate:
-Bromination of ethyl 6-amino-3-pyridinecarboxylate by reaction of ethyl 6-amino-3-pyridinecarboxylate with bromine to give ethyl 6-amino-3-bromo-2-pyridinecarboxylate.
-Through bromobenzonitrile reaction: 6-amino-3-pyridinecarboxylic acid ethyl ester is reacted with benzonitrile and copper chloride, and then brominated to obtain 6-amino-3-bromo-2-pyridinecarboxylic acid ethyl ester.
Safety Information:
- 6-amino -3-bromo -2-pyridine carboxylic acid ethyl ester in the preparation and use of the need to pay attention to protective measures, such as wearing protective glasses and gloves.
-It may cause irritation to the skin, eyes and respiratory tract, so contact and inhalation need to be avoided.
-When handling or handling the compound, try to control the emission of dust and solution to prevent environmental and health impacts.
-When storing, it should be kept in a dry, cool place, away from fire and oxidizing agents.
Last Update：2024-04-09 20:49:11
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Product Name: Ethyl 6-amino-3-bromopyridine-2-carboxylate Visit Supplier Webpage Request for quotation
CAS: 1214332-35-0
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