Ethyl 3-Oxo-4-(1-Boc-4-piperidyl)butyrate

Ethyl 3-Oxo-4-(1-Boc-4-piperidyl)butyrate - Names and Identifiers

Name	4-Piperidinebutanoic acid, 1-[(1,1-dimethylethoxy)carbonyl]-b-oxo-,ethyl ester
Synonyms	Ethyl 3-Oxo-4-(1-Boc-4-piperidyl)butyrate 1-Boc-b-oxo-4-piperidinebutanoic acid ethyl ester 1-BOC-BETA-OXO-4-PIPERIDINEBUTANOIC ACID ETHYL ESTER TERT-BUTYL 4-(4-ETHOXY-2,4-DIOXOBUTYL)PIPERIDINE-1-CARBOXYLATE TERT-BUTYL 4-(3-(ETHOXYCARBONYL)-2-OXOPROPYL)PIPERIDINE-1-CARBOXYLATE 4-(3-ethoxycarbonyl-2-oxopropyl)piperidine-1-carboxylic acid tert-butyl ester 4-Piperidinebutanoic acid, 1-[(1,1-dimethylethoxy)carbonyl]-b-oxo-,ethyl ester 4-Piperidinebutanoic acid, 1-[(1,1-dimethylethoxy)carbonyl]-β-oxo-, ethyl ester
CAS	916791-39-4

Ethyl 3-Oxo-4-(1-Boc-4-piperidyl)butyrate - Physico-chemical Properties

Molecular Formula	C16H27NO5
Molar Mass	313.39
Storage Condition	Room Temprature

Ethyl 3-Oxo-4-(1-Boc-4-piperidyl)butyrate - Introduction

4-Piperidinebutanoic acid, 1-[(1,1-dimethyllethoxy) carbonyl]-b-oxo-,ethyl ester is an organic compound with the formula C16H27NO5 and molecular weight of 313.39g/mol.

Nature:
4-Piperidinebutanoic acid, 1-[(1,1-dimenthylethoxy) carbonyl]-b-oxo-,ethyl ester is a colorless to pale yellow liquid with low volatility. It is stable at room temperature and soluble in many commonly used organic solvents.

Use:
4-Piperidinebutanoic acid, 1-[(1,1-dimethyllethoxy) carbonyl]-b-oxo-,ethyl ester is commonly used as a protecting group in drug synthesis to protect reactive sites such as amino and carboxyl groups to prevent unnecessary reactions. It can also be used for other reactions in organic synthesis, such as esterification, acylation, etc.

Method:
4-Piperidinebutanoic acid, 1-[(1,1-dimenthylethoxy) carbonyl]-b-oxo-,ethyl ester is generally prepared by the following steps:
1. mixing 4-piperidinobutyric acid with dimethylformamide (DMF), adding an activating agent (such as 1-(dimethylamino)-4-piperidine sodium) for condensation reaction to obtain N-dimethylformamide hydrochloride.
2. condensation reaction of N-dimethylformamide hydrochloride and 1-butynyl morpholine to obtain the desired product.
3. The product is reacted with Boc-Cl(N,N'-di-tert-butylaminochloromethane) in the presence of a base to give 4-Piperidinebutanoic acid, 1-[(1,1-dimethylethoxy)carbonyl]-b-oxo-,ethyl ester.

Safety Information:
4-Piperidinebutanoic acid, 1-[(1,1-dimenthylethoxy) carbonyl]-b-oxo-,ethyl ester has no obvious toxicity and harmfulness under general operating conditions. However, as an organic compound, it is necessary to take care to avoid contact with skin, eyes, etc., while avoiding inhalation of its vapor. In the use of the need to take appropriate protective measures, follow the laboratory safety procedures.

Last Update：2024-04-09 19:05:52