Name | Estriol |
Synonyms | E 3 Estriol ESTRIOL oestriol TRIDESTRIN ESTRIOL(P) Estriol (100 mg) ESTRA-1,3,5(10)-TRIENE-3,16,17-TRIOL 1,3,5(10)-Estratriene-3,16a,17b-triol ESTRA-1,3,5(10)-TRIENE-3,16ALPHA,17BETA-TRIOL Estra-1,3,5(10)-triene-3,16alpha,17beta-triol (16alpha,17beta)-estra-1,3,5(10)-triene-3,16,17-triol (8R,13S,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol Estriol,1,3,5(10)-Estratriene-3,16α,17β-triol, 16α-Hydroxyestradiol, 3,16α,17β-Trihydroxy-1,3,5(10)-estratriene |
CAS | 50-27-1 |
EINECS | 200-022-2 |
InChI | InChI=1/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13?,14-,15?,16?,17+,18+/m1/s1 |
InChIKey | PROQIPRRNZUXQM-ZXXIGWHRSA-N |
Molecular Formula | C18H24O3 |
Molar Mass | 288.38 |
Density | 1.27 |
Melting Point | 280-282°C(lit.) |
Boling Point | 370.61°C (rough estimate) |
Specific Rotation(α) | D25 +58° ±5° (0.04 g in 1 ml dioxane) |
Flash Point | 9℃ |
Water Solubility | 3.2mg/L(25 ºC) |
Solubility | Practically insoluble in water, sparingly soluble in ethanol (96 per cent). |
Vapor Presure | 1.34E-09mmHg at 25°C |
Appearance | White crystalline powder |
Color | White to Off-White |
Merck | 3707 |
BRN | 2508172 |
pKa | pKa 10.38±0.02(H2O t=23±2 Iunspeci?ed) (Uncertain) |
Storage Condition | 2-8°C |
Refractive Index | 58 ° (C=0.4, Dioxane |
MDL | MFCD00003691 |
Physical and Chemical Properties | Melting point 281-282°C |
Use | For the treatment of leukopenia, prostatic hypertrophy, prostate cancer also has a certain effect |
Risk Codes | R60 - May impair fertility R61 - May cause harm to the unborn child R40 - Limited evidence of a carcinogenic effect R45 - May cause cancer R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
Safety Description | S53 - Avoid exposure - obtain special instructions before use. S22 - Do not breathe dust. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. |
UN IDs | UN1230 - class 3 - PG 2 - Methanol, solution |
WGK Germany | 3 |
RTECS | KG8225000 |
FLUKA BRAND F CODES | 8-10 |
HS Code | 29072990 |
Toxicity | LD50 oral in rat: > 2gm/kg |
Reference Show more | 1. Luxin, Guo Qiusheng, Shi Hongzhu, etc. Effects of exogenous methyltestosterone on the growth and gonadal development of natural overwintering Leech. 2. Sha haolei, Zhang Zhiyan, Xia Jingfen, et al. Detection and risk assessment of typical environmental estrogens in Dongqian Lake, Ningbo [J]. Sichuan environment, 2015, 34(06):10-14. 3. Shi Hongjia, Chen Panpan, Guo Qiaosheng, etc. A preliminary study on the changes of sex steroid hormones in the gonad development cycle of Leech [J]. Chinese Journal of Traditional Chinese Medicine, 2018, 043(018):3639-3643. 4. Wang Shuai, Guo Qiusheng, Shi Hongzhu, etc. Effects of short-term addition of 17 β-e2 on growth and gonadal development of winter Leech. 5. Hanming Zhang, Zhiyun Meng, Tong Ye, Taoyun Liu, Jian Li, Fei Ma, Ruolan Gu, Xiaoxia Zhu, Zhuona Wu, Guifang Dou, Hui Gan,An UPLC-MS/MS method to monitor Estriol injection and comparison of pharmacokinetic characteristics after irradiation,Radiation Medi 6. [IF=6.057] Xuemei Wang et al."Enhanced in-out-tube solid-phase microextraction by molecularly imprinted polymers-coated capillary followed by HPLC Endocrine Disrupting Chemicals analysis."Talanta. 2019 Mar;194:7 7. [IF=3.591] Xuemei Wang et al."Application of ZIF-8-graphene oxide sponge to a solid phase extraction method for the analysis of sex hormones in milk and milk products by high-performance liquid chromatography."New J Chem. 2019 Feb;43(6):2783-2789 |
This product is white crystalline powder; Odorless; Tasteless. Soluble in pyridine, soluble in ethanol, ether, chloroform or dioxane, insoluble in water. Specific rotation 53. ~ 63.. Estriol is a metabolic product of estradiol and estrone in the body, and is a natural hormone mainly found in urine. Oral estrogen activity of this product is about 6 times of estrone, intramuscular injection is weak. It has a selective effect on the vagina and cervical canal, while it has no effect on the uterine solid and endometrium. The role of vaginal epithelial Keratinization is stronger than estradiol, can promote the vaginal mucosa angiogenesis and vaginal epithelial damage healing; At the same time can enhance the function of cervical cells, cervical fiber hyperplasia, thereby increasing the elasticity and softness of the uterine neck. In addition, this product has a feedback inhibitory effect on the hypothalamus and pituitary gland, does not inhibit ovulation, only has a significant impact on the corpus luteum function.