Name | Dibucaine |
Synonyms | Dibucaine Cinchocaine dibucaine usp Cinchocaine - USP dibucaine solution dibucaine free base crystalline 2-Butoxy-N-[2-(diethylamino)ethyl]cinchoninamide 2-butoxy-n-(2-(diethylamino)ethyl)-cinchoninamid 2-butoxy-n-(2-(diethylamino)ethyl)cinchoninamide 2-Butoxy-N-(beta-diethylaminoethyl)cinchoninamide 2-butoxy-N-(2-diethylaminoethyl)quinoline-4-carboxamide 2-butoxy-n-(2-(diethylamino)ethyl-4-quinolinecarboxamid 2-butoxy-n-(2-(diethylamino)ethyl)-4-quinolinecarboxamid 2-Butoxyquinoline-4-carboxylic acid diethylaminoethylamide |
CAS | 85-79-0 |
EINECS | 201-632-1 |
InChI | InChI=1/C20H29N3O2/c1-4-7-14-25-19-15-17(16-10-8-9-11-18(16)22-19)20(24)21-12-13-23(5-2)6-3/h8-11,15H,4-7,12-14H2,1-3H3,(H,21,24) |
Molecular Formula | C20H29N3O2 |
Molar Mass | 343.46 |
Density | 1.1145 (rough estimate) |
Melting Point | 64° |
Boling Point | 478.73°C (rough estimate) |
Flash Point | 254°C |
Water Solubility | 68.01mg/L(temperature not stated) |
Vapor Presure | 5.46E-10mmHg at 25°C |
Appearance | Solid:particulate/powder |
pKa | pKa -5.3(aq. H2SO4) (Uncertain) |
Refractive Index | 1.6300 (estimate) |
In vitro study | Dibucaine (Cinchocaine) reduces the degradation of BSA-gold complex in the reservosomes, which was not caused either by an inhibition of the whole proteolytic activity of the parasite or by a reduction on the expression levels of cruzipain. Dibucaine, a quaternary ammonium compound, inhibited SChE to a minimum within 2 min in a reversible manner. The inhibition was very potent. It had an IC(50) of 5.3 microM with BuTch or 3.8 microM with AcTch. The inhibition was competitive with respect to BuTch with a K(i) of 1.3 microM and a linear-mixed type (competitive/noncompetitive) with respect to AcTch with inhibition constants, K(i) and K(I) of 0.66 and 2.5 microM, respectively. Dibucaine possesses a butoxy side chain that is similar to the butryl group of BuTch and longer by an ethylene group from AcTch. |
Hazard Symbols | Xn - Harmful |
Risk Codes | R22 - Harmful if swallowed R41 - Risk of serious damage to eyes |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. |
RTECS | GD3150000 |