Molecular Formula | C17H32O10 |
Molar Mass | 396.42998 |
Melting Point | 483 °C (decomp) |
Boling Point | -85.05ºC at 760 mm Hg |
Specific Rotation(α) | 198 º |
Water Solubility | Soluble in water, dimethyl sulfoxide, ethylene glycol and glycerol. |
Solubility | Soluble in water. Slightly soluble in ethanol. |
Appearance | White crystal or powder |
Color | White to slightly off-white |
Merck | 14,2948 |
PH | 2 - 10 |
Storage Condition | 2-8°C |
Stability | Stable. Keep dry. Incompatible with strong oxidizing agents. |
Sensitive | Easily absorbing moisture |
Refractive Index | 185 ° (C=6, H2O) |
MDL | MFCD00130935 |
Physical and Chemical Properties | Iron Dextran Injection is a dark brown colloidal solution. The iron dextran solid was a dark tan amorphous powder. Odorless and astringent. Hygroscopic in the air. Soluble in water, the solution is dark brown colloidal solution, ph 5.2-6.5, insoluble in organic solvents such as ethanol. Iron Dextran Injection is a complex of iron and dextran. After intramuscular injection, part of the iron was phagocytosed by macrophages and transferred to fibroblasts, and the rest of the iron was slowly removed from the injected part (50% at 72h) and transferred to plasma via lymph. Three weeks after the injection, iron was still found in the blood. Iron was mainly stored in the reticuloendothelial cells of the liver and spleen and was slowly released for the need of hemoglobin synthesis. This absorption pathway is not controlled by the gastrointestinal tract, so the recovery of stored iron is rapid and complete. However, the rate of increase in hemoglobin is still the same as that of oral preparations, averaging about 0.15g per day. Effective for iron deficiency anemia. |
Use | Medium molecule dextran is mainly used to increase plasma volume and maintain blood pressure, with anti Shock as the main. It is suitable for supplementing blood volume and maintaining blood pressure when there is a large amount of blood loss. Such as burns, trauma, trauma and other hemorrhagic and due to excessive blood loss caused by the body grams of first aid. Low molecular dextran, mainly to improve microcirculation, for the prevention or elimination of intravascular red blood cell aggregation and thrombosis. The action and use of small molecule dextran is similar to that of low molecular dextran. |
Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S24/25 - Avoid contact with skin and eyes. S37/39 - Wear suitable gloves and eye/face protection S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
WGK Germany | 2 |
RTECS | HH9230000 |
FLUKA BRAND F CODES | 3 |
TSCA | Yes |
HS Code | 39139000 |
Toxicity | LD50 oral in rat: > 3gm/kg |
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This product is white powder. Odorless and tasteless. Soluble in hot water, insoluble in ethanol. Dextran is a dehydration polymer of several glucose molecules, also known as dextran, which widely exists in microorganisms in nature and is an important part of cell wall. Due to its large molecular weight, it cannot be directly used for medicine, it must be hydrolyzed into molecules of a certain size. The molecular weight of 25000~50000 is low molecule, 50000~0000 is medium molecule. This product is a low molecular dextran, mainly used for blood volume expansion agent, the aqueous solution of colloidal solution, can maintain good colloid osmotic pressure. Easily excreted from the kidney, half-life of only 3 hours. The osmotic pressure of 10% solution is slightly higher than that of plasma protein, which can absorb the liquid in the tissue into the blood, so it can dilute the blood quickly, reduce the hematocrit and plasma viscosity, accelerate the blood flow, and dredge the microcirculation, it can reduce the aggregation of red blood cells in blood vessels and platelet aggregation. Also hinder the platelet release of the third factor, a mild anticoagulant effect.
high molecular weight glucose polymer produced by sucrose of this strain after fermentation by Leuconostoc Leuconostoc mesenteroides No. L.-M-1226, was obtained by treatment and purification. The weight average molecular weight (Mw) of dextran 20 should be from 16,000 to 24,000.
take this product, precision weighing, add water to dissolve and quantitatively dilute to make a solution containing about 10 mg per lml, at 25°C, according to the law (General 0621), the specific rotation was 190 ° to 200 °.
blood volume supplement.
take 0.2g of this product, add 5ml of water to dissolve, add 2ml of sodium hydroxide test solution and several drops of copper sulfate test solution to generate light blue precipitate, and turn brown precipitate after heating.
stored in a dry place.
take an appropriate amount of this product, add the mobile phase to dissolve and dilute to make a solution containing about 10 mg per lml, shake, and place overnight as the test solution; in addition, 4 to 5 dextran reference products of known molecular weight were taken, and a solution containing 10 mg per 1 ml was prepared as a reference solution by the same method. According to the molecular exclusion chromatography method (General 0514), the hydrophilic spherical polymer is used as the filler (TSKGPWXL column, ShodexOHpakSBHQ column or other suitable column); The mobile phase is 0.71% sodium sulfate solution (containing 0.02% sodium azide); column temperature was 35°C; Flow rate was 0.5ml per minute; Differential refractive index detector.
take 0.10g of this product, add 50ml of water, heat and dissolve, cool, take 10ml of solution, check according to law (General rule 0801), and compare with the control solution made of 5ml of standard sodium chloride solution, no more concentrated (0.25%).
take 0.20g of this product, put it in a 50ml Kjeldahl Flask, add 1ml of sulfuric acid, heat and digest until the test product is black oily, let it cool, add 2ml of 30% hydrogen peroxide solution, heat and digest until the solution is clear (if it is not clear, add 0.5~1.0 of the above hydrogen peroxide solution and continue heating), cool to below 20°C, Add 10ml of water, add 5% sodium hydroxide solution Dropwise to make it alkaline, move it to 50ml Cuvette, wash the flask with water, wash the flask with human Cuvette, dilute it with water until the scale, slowly add 2ml alkaline mercuric iodide test solution, shake with the addition (the temperature of the solution is kept below 20°C); In case of color development, mix with standard ammonium sulfate solution (precision weighing 105g of ammonium sulfate dried at 0.4715°C to constant weight), in a 100ml measuring flask, water was added to dissolve and dilute to the scale, mixed well, and used as a stock solution. At the time of use, take 1ml stock solution accurately, put it in a 100ml measuring flask, dilute it with water to the scale, and shake it well. Each 1ml equivalent to the lOug of N) 0.007% ml plus sulfuric acid after treatment with the same method of color comparison, not deeper ().
take this product, dry at 105°C for 6 hours, loss of weight shall not exceed 5.0% (General rule 0831).
take 1.5g of this product and check it according to law (General rule 0841). The remaining residue shall not exceed 0.5%.
The residue left under the ignition residue item shall not contain more than 8 parts per million of heavy metals after examination by law (General Principles 0821, Law II).
Plasma substitutes.
sealed and stored in a dry place.
This product is a sterile aqueous solution of dextran 20 and glucose. Dextran 20 and glucose (C6H1206 • H20) should be 95 of the labeled amount. 0 ~ 105.0%.
This product is colorless, slightly viscous clear liquid, sometimes slight opalescence.
glucose precision take this product 2ml, put the iodine bottle, precision Iodine titration solution (0.05mol/L)25ml, while shaking the drop of sodium hydroxide titration solution (0.lmol/L )50ml, placed in the dark for 30 minutes, plus dilute sulfuric acid 5ml, with sodium thiosulfate titration solution (0.lmol/L) titration, when the end point is near, add 2ml of starch indicator solution, continue titration until the blue color disappears, and use 0.12g(6% specification) or 0.20g (10% specification) of dextran 20 for blank test correction. This corresponds to 9.909mg of C6H1206 • H2O per 1 ml of iodine titrant (0.05mol/L).
with dextran 20.
(1) 10% Dextran 20 and Glucose Injecrion ML: 10g dextran 20 with 5g glucose; 250ml:25g dextran 20 with 12.5g glucose; 500ml:50g dextran 20 with 25g glucose
(2) 6% Dextran 20 and Glucose Injecrion 100ml:6g dextran 20 with 5g glucose; 250ml:15g dextran 20 with 12.5g glucose; 500ml:30g dextran 20 with 25g glucose
sealed storage at 25°C or less.
This product is a sterile aqueous solution of dextran 20 and sodium chloride. Dextran 20 and sodium chloride (NaCl) should be 95.0% to 105.0% of the label amount.
This product is colorless, slightly viscous clear liquid, sometimes slight opalescence.
with dextran 20.
sealed storage at 25°C or less.