Molecular Formula | C32H38N2O8 |
Molar Mass | 578.65 |
Density | 1.2277 (rough estimate) |
Melting Point | 228-232°; mp 230-232°; mp 138° and 226-232° with resolidification at 175° |
Boling Point | 638.28°C (rough estimate) |
Specific Rotation(α) | D20 -163° (c = 0.5 in pyridine) |
Flash Point | 362.7°C |
Solubility | Chloroform (Slightly), Methanol (Slightly) |
Vapor Presure | 3.87E-18mmHg at 25°C |
Appearance | Solid |
Color | White to Off-White |
pKa | 6.68 in 40% methanol |
Storage Condition | -20°C Freezer |
Refractive Index | 1.6260 (estimate) |
Use | For HPLC determination |
In vitro study | Deserpidine is an effective ganglionic blocking agent, which differs from Reserpine only by the absence of a methoxy group at C-11. Deserpidine has been used in the treatment of hypertension and psychosis. In addition, Deserpidine appears to act as a controller of other cardiac disorders. |
NIST chemical information | Information provided by: webbook.nist.gov (external link) |
use | desheping is the main ingredient in the preparation of antihypertensive drugs, also known as reserpine ester, demoxyreserpine, and snake root leveling. |
biological activity | Deserpidine (Harmonyl) is an alkaloid isolated from the roots of Rauwolfia canescens related to Reserpine. Deserpidine are used as antihypertensive drugs and tranquilizers. Deserpidine is a competitive angiotensin converting enzyme (ACE) inhibitor. Deserpidine also reduced adrenocortical angiotensin II-induced aldosterone secretion. |
target | Angiotensin converting enzyme (ACE) |