Dapoxetine hydrochloride Impurity M

Dapoxetine hydrochloride Impurity M - Names and Identifiers

Name	(R)-(+)-3-chloro 1-phenyl-1-propanol
Synonyms	3-chloro-1-phenylpropan-1-ol (R)-(+)-3-CHLORO-1-PHENYL-1-PR (1R)-3-Chloro-1-phenyl-propan-1-ol (R)-(+)-3-chloro 1-phenyl-1-propanol Dapoxetine hydrochloride Impurity M (R)-(+)-3-Chloro-1-phenyl-1-propanol (αR)-α-(2-Chloroethyl)benzeneMethanol R-(+)-1-chloro-3-hydroxy-3-phenylpropane Benzenemethanol, α-(2-chloroethyl)-, (αR)- (1R)-3-Chloro-1-Phenyl-Propan-1-ol (R)-(+)-3 (R)-(+)-3-CHLORO-1-PHENYLPROPANOL((R)-3-chloro-1-phenylpropan-1-ol) α-(2-Chloroethyl)benzyl alcohol, (R)-(+)-α-(2-Chloroethyl)benzyl alcohol, (R)-(+)-3-Chloro-1-phenylpropanol
CAS	100306-33-0
EINECS	627-168-3
InChI	InChI=1/C9H11ClO/c10-7-6-9(11)8-4-2-1-3-5-8/h1-5,9,11H,6-7H2/t9-/m1/s1
InChIKey	JZFUHAGLMZWKTF-SECBINFHSA-N

Dapoxetine hydrochloride Impurity M - Physico-chemical Properties

Molecular Formula	C9 H11 Cl O
Molar Mass	170.64
Density	1.149±0.06 g/cm3(Predicted)
Melting Point	58-60 °C (lit.)
Boling Point	296.4±20.0 °C(Predicted)
Specific Rotation(α)	26 º (c=1, chloroform)
Flash Point	132°C
Solubility	Chloroform (Slightly), Methanol (Slightly)
Vapor Presure	0.000651mmHg at 25°C
Appearance	White crystal
Color	White to yellow
BRN	5250766
pKa	13.92±0.20(Predicted)
Storage Condition	Inert atmosphere,Room Temperature
Refractive Index	1.543
MDL	MFCD00075128

Dapoxetine hydrochloride Impurity M - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3
HS Code	29062990
Hazard Class	IRRITANT

Dapoxetine hydrochloride Impurity M - Introduction

(R)-(+)-3-Chloro-1-phenyl-1-propanol, also known as (R)-(+)-α-methylphenylethanol, is a chiral organic compound. Its chemical formula is C9H11ClO and its molecular weight is 168.63g/mol.

It is a colorless or yellowish liquid with a special fragrance. It has a low boiling point and melting point at normal temperature, and is soluble in water and organic solvents such as ethyl ether and alcohols.

The compound has a wide range of applications in organic synthesis. It can be used as a chiral inducer or a starting material of chiral catalyst to synthesize chiral compounds with biological activity. In addition, it can also be used in the preparation of liquid crystals, dyes, pharmaceuticals and pesticides.

The preparation methods of (R)-( )-3-chloro-1-phenyl-1-propanol are diversified. One commonly used method is synthesis by reaction with p-bromotoluene. First, (R)-( )-phenylpropanone is reacted with magnesium bromide to obtain (R)-( )-phenyl-2-propanol, and then the target compound is prepared by Grignard reaction with stannous chloride.

Regarding safety information, the compound should be used and stored in accordance with the appropriate safety procedures. It is a flammable liquid and should be kept away from fire and high temperatures, avoiding contact with oxidants and strong acids. At the same time, care should be taken to avoid inhaling its vapor or contact with skin and eyes. If accidentally contacted, rinse immediately with plenty of water and seek medical help.

Last Update：2024-04-09 20:02:46

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