Name | Climbazole |
Synonyms | MEB-6401 Diadimefon Climbazole Crinipan AD BAY MEB-6401 Climbazole 0.1 1-[(4-Chlorophenoxy)(tert-butylcarbonyl)Methyl]iMidazole 1-(4-chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutanone 1-(4-clorophenoxy)-3,3-dimethyl-1-(imidazole-1-yl)-2-butanone 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one 1-(4-Chloro-phenoxy)-1-(2,5-dihydro-imidazole-1-yl)-3,3-dimethyl-butan-2-one |
CAS | 38083-17-9 |
EINECS | 253-775-4 |
InChI | InChI=1/C15H17ClN2O2/c1-15(2,3)13(19)14(18-9-8-17-10-18)20-12-6-4-11(16)5-7-12/h4-10,14H,1-3H3 |
InChIKey | OWEGWHBOCFMBLP-UHFFFAOYSA-N |
Molecular Formula | C15H17ClN2O2 |
Molar Mass | 292.76 |
Density | 1.17±0.1 g/cm3(Predicted) |
Melting Point | 96-100°C |
Boling Point | 447.5±40.0 °C(Predicted) |
Flash Point | 224.4°C |
Water Solubility | 58mg/L at 25℃ |
Solubility | DMSO : ≥ 47 mg/mL (160.54 mM). Easily soluble in toluene and methanol, hardly soluble in water. |
Vapor Presure | 0.001Pa at 25℃ |
Appearance | White to off-white (Solid) |
Color | White to Almost white |
BRN | 618020 |
pKa | 5.66±0.22(Predicted) |
Storage Condition | Inert atmosphere,Room Temperature |
Refractive Index | 1.54 |
MDL | MFCD00055505 |
Physical and Chemical Properties | white or off-white crystalline or crystalline powder |
Use | With broad-spectrum bactericidal properties, mainly used for anti-itching and anti-dandruff conditioning shampoo, hair care shampoo, can also be used for antibacterial soap, shower gel, drug toothpaste, Oral Liquid, etc |
In vitro study | Climbazole exhibits high anti-Pityrosporum ovale efficacy both in vivo and in vitro, and Pityrosporum ovale may be the main cause of dandruff. The chemical structure and properties of Climbazole are similar to other antifungal agents, such as ketoconazole and miconazole. The MICs of climbazole ranged between <0.06 and 1 μg/mL, with an experimental median of 0.06 μg/mL. |
In vivo study | Climbazole is not mutagenic in the Salmonella typhimurium or Escherichia coliAmes test and does not induce micronuclei in human lymphocytes. An in vivo mouse micronucleus test also showed no mutagenicity, with a maximum tolerance dose (MTD) of up to 150 mg/kg administered orally. In an in vitro and in vivo unconventional DNA synthesis assay, climbazole showed no damage to DNA in rat livers when administered orally with MTD up to 200 mg/kg. In mice, [ |
Risk Codes | R22 - Harmful if swallowed R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
Safety Description | S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
UN IDs | UN 3077 |
WGK Germany | 3 |
RTECS | EL7085000 |
HS Code | 29332900 |