Clevidipine Butyrate Impurity 6

Clevidipine Butyrate Impurity 6 - Names and Identifiers

Name	4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-Pyridinedicarboxylic acid 3-(2-cyanoethyl) 5-methyl ester
Synonyms	Clevidipine butyrate-5 Clevidipine Butyrate Impurity 6 Clevidipine Butyrate iMpurity Ⅵ 2-Cyanoethyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate 4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-cyano-ethyl) 4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-cyano-ethyl) es 3-(2-cyanoethyl) 5-Methyl 4-(2',3'-dichlorophenyl)-2,6-diMethyl-1,4-dihydropyridine-3,5-dicarboxylate 5-O-(2-cyanoethyl) 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, 2-cyanoethyl methyl ester 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-Pyridinedicarboxylic acid 3-(2-cyanoethyl) 5-methyl ester 4-(2,3-dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-cyano-ethyl) ester 5-methyl ester 4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-cyano-ethyl) ester 5-methyl ester
CAS	110962-94-2
EINECS	1312995-182-4
InChI	InChI=1S/C19H18Cl2N2O4/c1-10-14(18(24)26-3)16(12-6-4-7-13(20)17(12)21)15(11(2)23-10)19(25)27-9-5-8-22/h4,6-7,16,23H,5,9H2,1-3H3

Clevidipine Butyrate Impurity 6 - Physico-chemical Properties

Molecular Formula	C19H18Cl2N2O4
Molar Mass	409.26
Density	1.317±0.06 g/cm3(Predicted)
Boling Point	552.6±50.0 °C(Predicted)
pKa	2.54±0.70(Predicted)

Clevidipine Butyrate Impurity 6 - Introduction

Clevidipine ester is a drug with the chemical name (5R,6R)-2-[[(2S)-2-(3,4-dichlorophenyl)-2-(2-propoxyethyl)-1,3-dioxolan-4-yl]methyl]-6-(1,3-benzodiol-5-yl)-pyridin -2,3,5. The following is a description of the properties, uses, preparation and safety information of clevidipine ester:

Nature:
-Appearance: Clevidipine ester is a white to off-white crystalline powder.
-Solubility: clevidipine ester is soluble in ethanol, chloroform, slightly soluble in ether, dichloromethane, almost insoluble in water.
-Melting point: about 149-152 ℃.

Use:
-Clevidipine ester is a calcium channel blocker, mainly used to treat hypertension and angina.
-It reduces the influx of calcium ions in the heart and vascular smooth muscle by blocking the L-type calcium channel on the cell membrane, thereby reducing the load on the heart and the contraction of blood vessels.

Preparation Method:
Clevidipine ester can be synthesized by the following steps:
1. First, 3,4-dichloroacetophenone was used as a starting material and reacted with 2-propoxy ethanol to obtain the precursor of clevidipine.
2. Next, the precursor is reacted with 1,3-propanediol lactone in the presence of a catalyst to produce clevidipine ester.

Safety Information:
-When using or handling clevidipine ester, you need to comply with relevant safety procedures, including wearing gloves, avoiding contact with skin and eyes, and maintaining a good ventilation environment.
-Clevidipine is intended for medical use only and is not permitted as a food, beverage or household chemical.
-Follow your doctor's prescription or pharmacist's advice when using clevidipine, and should not be used on your own or over the recommended dose.
-If an allergic reaction or other discomfort occurs, stop using clevidipine ester immediately and consult a doctor.

Last Update：2024-04-09 21:01:54