Name | Candesartan |
Synonyms | D00522 C07468 Blopress CV 11974 Candesartan Blopress (TN) Candesartan M1 Candesartan (USAN) 1H-Benzimidazole-7-carboxylic acid Candesartan Cilexetil EP IMpurity G 2-ethoxy-1-((2'-(1H-tetrazol-5-yl) (1,1'-biphenyl)-4-yl)methyl)- 2-Ethoxy-1-(p-(o-1H-tetrazol-5-ylphenyl)benzyl)-7-benzimidazolecarboxy lic acid 3-[[2'-(1H-Tetrazol-5-yl)biphenyl-4-yl]Methyl]-2-ethoxy-3H-benziMidazole-4-carboxylic Acid 2-ethoxy-1-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid 2-Ethoxy-3-[[4-[2-(1H-tetrazol-5-yl)phenyl]phenyl]methyl]-3H-benzoimidazole-4-carboxylic acid 2-ethoxy-3-[[4-[2-(1h-tetrazol-5-yl)phenyl]phenyl]methyl]-3h-benzoimidazole-4-carboxylic acid 2-ETHOXY1-2(1H-TETRAZOL-5YL)1,1-BIPHENYL)-4-YL)-4-YL)METHYL)1H-BENZIMIDAZOLE-7-CARBOXYLIC ACID 1-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic 2-ethoxy-1-({2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl}methyl)-1H-benz imidazole-7-carboxylic acid 1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- 1-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-2-ethoxy-1H-benzo[d]iMidazole-7-carboxylic acid 1-{[(cyclohexyloxy)carbonyl]oxy}ethyl 2-ethoxy-1-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate |
CAS | 139481-59-7 |
EINECS | 604-138-8 |
InChI | InChI:1S/C24H20N6O3/c1-2-33-24-25-20-9-5-8-19(23(31)32)21(20)30(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-26-28-29-27-22/h3-13H,2,14H2,1H3,(H,31,32)(H,26,27,28,29) |
Molecular Formula | C24H20N6O3 |
Molar Mass | 440.45 |
Density | 1.41±0.1 g/cm3(Predicted) |
Melting Point | 183-185°C |
Boling Point | 754.8±70.0 °C(Predicted) |
Flash Point | 411.6°C |
Water Solubility | Soluble in ethyl acetate, methanol, water (<1 mg/ml at 25°C), DMSO (88 mg/ml at 25°C), and ethanol (1 mg/ml at 25°C). |
Solubility | Soluble in ethyl acetate, methanol, water (<1 mg/ml at 25 °C), DMSO (88 mg/ml at 25 |
Vapor Presure | 4.39E-24mmHg at 25°C |
Appearance | Powder |
Color | White |
pKa | 2.06±0.10(Predicted) |
Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
Refractive Index | 1.746 |
MDL | MFCD00081076 |
Physical and Chemical Properties | Melting Point: 183-185°C |
Use | Angiotensin II receptor antagonists for the treatment of hypertension |
Hazard Symbols | Xn - Harmful |
Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S60 - This material and its container must be disposed of as hazardous waste. S36/37 - Wear suitable protective clothing and gloves. S9 - Keep container in a well-ventilated place. |
RTECS | DD6671000 |
HS Code | 29419000 |
Reference Show more | 1. Liu Chang, Zhang Zhenghao, Xu Shiqing. Effects of candesartan and captopril on the level of reactive oxygen species in aorta of type 1 diabetic mice [J]. Journal of China-Japan Friendship Hospital, 2020, v.34;No.177(03):2 27-30. |
from acetic acid ethanol methanol colorless crystals, melting point 183~185 deg C
3-nitrophthalic acid was dissolved in ethanol containing concentrated sulfuric acid and reacted under reflux. The obtained monoester and thionyl chloride were dissolved in benzene and subjected to an acylation reaction under reflux. The obtained acid chloride was dissolved in dichloromethane, and added dropwise to the dimethylformamide solution of sodium azide under vigorous stirring, and then refluxed with tert-butyl alcohol, 2-tert-butoxycarbonylamino-3-nitrobenzoic acid ethanol was obtained. The ester is dissolved in Tetrahydrofuran, stirred and ice bath cooling, adding NaH, room temperature stirring, and then add 4-(2-cyanophenyl) benzyl bromide and potassium iodide reaction, the obtained compound was dissolved in ethanol, and tin chloride dihydrate was added for reaction. The reaction product is dissolved in ortho-ethyl carbonate, and acetic acid is added to form a benzimidazole derivative by cyclization. The imidazole derivative and trimethyltin azide are dissolved in toluene and reacted under reflux to form a tetrazole ring. The Tetrazole derivative was hydrolyzed to obtain candesartan.
developed by Takeda Chem.1nd.Ltd., Japan, was launched in Sweden in 1997. Antihypertensive drugs. Angiotensin II type 1 receptor antagonist. In the human body, it is hydrolyzed into acid to produce an effect. The antihypertensive effect of this kind of drugs is remarkable, the action time is long, and it has the protective effect on the heart, kidney and cerebral blood vessels, and can reduce the left ventricular myocardial hypertrophy.