Caffeine Impurity 6(Caffeine EP Impurity F)
1,7-dimethylxanthine
CAS: 611-59-6
Molecular Formula: C7H8N4O2
Caffeine Impurity 6(Caffeine EP Impurity F) - Names and Identifiers
Caffeine Impurity 6(Caffeine EP Impurity F) - Physico-chemical Properties
| Molecular Formula | C7H8N4O2 |
| Molar Mass | 180.16 |
| Density | 1.3640 (rough estimate) |
| Melting Point | 294-296 °C (lit.) |
| Boling Point | 312.97°C (rough estimate) |
| Flash Point | 9℃ |
| Solubility | ethanol: 0.6mg/mL |
| Appearance | solid |
| Color | white |
| BRN | 197907 |
| pKa | pKa 8.5 (Uncertain) |
| Storage Condition | room temp |
| Stability | Store tightly sealed at RT |
| Refractive Index | 1.6700 (estimate) |
| In vitro study | When Paraxanthine (PX) is applied to the cultures for a prolonged period, the number of TH +neurons is augmented in a dose-dependent manner. The effect of Paraxanthine, already significant at 100 μM, increases gradually and remains optimal between 800 and 1000 μM, at 10 DIV. Counts of TH +neurons performs at different stages of maturation of the cultures indicate that Paraxanthine most likely prevents DA cell loss. GDNF, a prototypical trophic factor for DA neurons, is only slightly more effective than 800 μM Paraxanthine in rescuing DA neurons after 10 and 16 DIV when used at an optimal concentration of 20 ng/mL. About 80% of caffeine is N3-demethylated to form Paraxanthine, Unlike Paraxanthine, caffeine is poorly effective in protecting DA neurons from death For example, at a concentration of 800 μM, caffeine produces only a modest 40% increase in the number of TH + cells at 10 DIV, whereas the same concentration of Paraxanthine optimally promotes DA cell survival (169% increase). |
Caffeine Impurity 6(Caffeine EP Impurity F) - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. S7 - Keep container tightly closed. |
| UN IDs | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 3 |
| RTECS | RV9380000 |
| Toxicity | mmo-esc 150 mg/L CSHSAZ 16,337,52 |
Caffeine Impurity 6(Caffeine EP Impurity F) - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| biological activity | Paraxanthine, a metabolite of caffeine, inhibits dopaminergic cell death by stimulating Ryanodine receptor channels. |
Last Update：2024-04-09 21:01:54
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View History
Caffeine Impurity 6(Caffeine EP Impurity F)
N-{2-[(4-methyl-1-piperazinyl)carbonyl]phenyl}-3-propoxybenzamide
β-Cyclocitral,2,6,6-Trimethyl-1-cyclohexene-1-carboxaldehyde
SALOR-INT L232505-1EA
2-(2-甲基-3-硝基苯基)乙酰氯
1-{[4-(acetylamino)phenyl]sulfonyl}-1',4-bipiperidine-4-carboxamide
5-BROMO-4-CHLORO-3-INDOLYL-BETA-D-GLUCOPYRANOSIDE (X-GLU)
3-DIETHYLAMINOPROPIONIC ACID ETHYL ESTER
6-羟基苯并[d][1,3]氧硫杂环戊烷2-酮
CS-2047
N-{2-[(4-methyl-1-piperazinyl)carbonyl]phenyl}-3-propoxybenzamide
β-Cyclocitral,2,6,6-Trimethyl-1-cyclohexene-1-carboxaldehyde
SALOR-INT L232505-1EA
2-(2-甲基-3-硝基苯基)乙酰氯
1-{[4-(acetylamino)phenyl]sulfonyl}-1',4-bipiperidine-4-carboxamide
5-BROMO-4-CHLORO-3-INDOLYL-BETA-D-GLUCOPYRANOSIDE (X-GLU)
3-DIETHYLAMINOPROPIONIC ACID ETHYL ESTER
6-羟基苯并[d][1,3]氧硫杂环戊烷2-酮
CS-2047