CYPROHEPTADINE HCI

CYPROHEPTADINE HCI - Names and Identifiers

Name	Cyproheptadine hydrochloride
Synonyms	CYPROHEPTADINE HCI Hydrochloride sesquihydrate Cyproheptadine hydrochlorid Cyproheptadine hydrochloride 4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-piperidine hydrochloride hydrate
CAS	41354-29-4
EINECS	623-762-1

CYPROHEPTADINE HCI - Physico-chemical Properties

Molecular Formula	C21H24ClNO
Molar Mass	341.88
Melting Point	165°C (dec.)(lit.)
Boling Point	440.1 °C at 760 mmHg
Solubility	ethanol: soluble;methanol: soluble
Appearance	solid(white to slightly yellow)
Color	white to slightly yellow
Maximum wavelength(λmax)	['285nm(0.05mol/L H2SO4)(lit.)']
Merck	14,2773
Storage Condition	Inert atmosphere,Room Temperature
MDL	MFCD00150043

CYPROHEPTADINE HCI - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
UN IDs	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	TM7050000
HS Code	29333990
Hazard Class	6.1
Packing Group	III
Toxicity	LD50 orally in mice: 74.2 mg/kg (Loux)

CYPROHEPTADINE HCI - Reference Information

Introduction	cyproheptadine hydrochloride, also known as diphenylcycloheptadine, metapantin, ethylphenylcycloheptadine, A hexahydropyridine antihistamine that competes with histamine released from tissues for H1 receptors on effector cells, thereby preventing the onset of allergic reactions, relieve histamine induced spasmolysis and hyperemia, the goods have a strong H1 receptor antagonism, antihistamine effect than chlorpheniramine, promethazine strong. Mild to moderate anti-serotonin and anti-cholinergic effects. In addition, there is the role of stimulating appetite, after a certain period of time visible weight gain.
indications	cyproheptadine hydrochloride hemihydrate is mainly used for acute and chronic urticaria (especially cold urticaria has good effect), papular urticaria, angioedema, allergic eczema, contact dermatitis, food allergy, drug allergy, allergic rhinitis, hay fever, allergic conjunctivitis, insect sting allergy and migraine. It has a certain therapeutic effect on bronchial asthma. Can be used for Cushing's syndrome, acromegaly adjuvant therapy. It can also be used as an appetite enhancer for anorexia nervosa. Treatment of acanthosis nigricans and prevention of necrotizing pyoderma have been reported.
dosage	oral dosage form (1) allergic diseases: adults, 2~4mg once, 2-3 times a day. (2) hypercortisolism, suitable for the treatment of bilateral adrenal hyperplasia, which can inhibit the release of corticotropin-releasing hormone (CRH) from hypothalamus and pituitary adrenocorticotropic hormone (ACTH) the secretion, thereby reducing the level of plasma ACTH and cortisol; Adults start 8mg a day, can be gradually increased to 24mg a day; The commonly used dose is 12~24mg a day, divided into doses, need long-term application; in the case of insufficient cortical function after bilateral total or Subtotal adrenalectomy, on the one hand, adding corticosteroids, on the other hand, taking cyproheptadine can reduce the chance of pituitary tumor.
drug interaction	1. It should not be combined with ethanol, which can increase its sedative effect. 2. Should not be combined with the central nervous system inhibitory drugs. 3. Combined with phenothiazine drugs (such as chlorpromazine, etc.) can increase the risk of ventricular arrhythmia, and in severe cases can cause torsade de pointes. 4. If concomitant use with other drugs may cause drug interaction, for details, please contact Counseling physician or pharmacist.
Use	for the treatment of urticaria, pruritus, allergic rhinitis. new anticoagulant and antiallergic drugs. Can be used for urticaria, eczema, allergic and contact dermatitis, skin itching and other allergic reactions. Urticaria, eczema, allergic and contact dermatitis, skin itching, rhinitis, migraine, bronchial asthma, etc. It can also be used for Cushing's disease and acromegaly. 5-HT2/5-HT1C serotonin receptor antagonist; H1 histamine receptor antagonist; Antipruritic agent

Last Update：2024-04-09 15:16:51

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