CYCLOHEXYLMANDELIC ACID METHYL ESTER
Methyl cyclohexylphenylglycolate
CAS: 10399-13-0
Molecular Formula: C15H20O3
CYCLOHEXYLMANDELIC ACID METHYL ESTER - Names and Identifiers
CYCLOHEXYLMANDELIC ACID METHYL ESTER - Physico-chemical Properties
| Molecular Formula | C15H20O3 |
| Molar Mass | 248.32 |
| Density | 1.130±0.06 g/cm3(Predicted) |
| Melting Point | 40 °C |
| Boling Point | 170-175 °C(Press: 9 Torr) |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Appearance | Solid |
| Color | White to Off-White Waxy to |
| pKa | 12.19±0.29(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Use | Application 2-cyclohexyl-2-hydroxyphenylacetic acid methyl ester is an organic intermediate, it has been reported that it can be prepared from bromocyclohexane and 2-oxo-2-phenylacetic acid -2-methyl ester or benzoyl formate and cyclohexene as starting materials, and can be used in laboratory research and development process and chemical production process. |
CYCLOHEXYLMANDELIC ACID METHYL ESTER - Risk and Safety
| HS Code | 2918191350 |
CYCLOHEXYLMANDELIC ACID METHYL ESTER - Upstream Downstream Industry
CYCLOHEXYLMANDELIC ACID METHYL ESTER - Preparation
Under nitrogen, bromocyclohexane (5.96g,36.55 mmol) is added dropwise to the anhydrous ether mixture of magnesium chips (0.87g,36.25 mmol) and iodine crystals, first 1 mL is added, and the rest is added after the start of the reaction, while maintaining mild reflux. Stir the mixture at room temperature until all magnesium is dissolved (1 hour). The cyclohexylmagnesium bromide solution thus obtained was cooled to 0°C. Tetrahydrofuran (20mL) solution of 2-oxo-2-phenylacetic acid (3.0g,18.29mmol) was added dropwise. The reaction mixture was allowed to reach room temperature and stirred for 2 hours. It was then cooled to 0°C, quenched by slowly adding a saturated ammonium chloride solution and extracted with ethyl acetate. The organic layer was washed with water and brine, dried by Na2SO4, and the solvent was evaporated under reduced pressure to give a crude residue, which was purified by silica gel column chromatography (1.5% ethyl acetate in petroleum ether) to obtain yellow viscous 2-cyclohexyl-2-hydroxyphenylacetate methyl, liquid (2.6g,57%).
Last Update：2024-04-10 22:29:15
CYCLOHEXYLMANDELIC ACID METHYL ESTER - Reference Information
| application | 2-cyclohexyl -2-hydroxyphenylacetic acid methyl ester is an organic intermediate. It is reported in the literature that it can be prepared from bromocyclohexane and 2-oxo-2-phenylacetic acid -2-methyl ester or benzoformate and cyclohexene as starting materials, it can be used in laboratory research and development process and chemical production process. |
| Preparation | Under nitrogen, bromocyclohexane (5.96g,36.55 mmol) is added dropwise to the anhydrous ether mixture of magnesium chips (0.87g,36.25 mmol) and iodine crystals, 1 mL is added first, and the rest is added after the reaction starts while maintaining mild reflux. Stir the mixture at room temperature until all magnesium is dissolved (1 hour). The cyclohexylmagnesium bromide solution thus obtained was cooled to 0°C. Tetrahydrofuran (20mL) solution of 2-oxo-2-phenylacetic acid (3.0g,18.29mmol) was added dropwise. The reaction mixture was allowed to reach room temperature and stirred for 2 hours. It was then cooled to 0°C, quenched by slowly adding a saturated ammonium chloride solution and extracted with ethyl acetate. The organic layer was washed with water and salt water, dried by Na2SO4, and the solvent was evaporated under reduced pressure to give a crude residue, which was purified by silica gel column chromatography (ethyl 1.5% acetate in petroleum ether) to obtain yellow viscous 2-cyclohexyl-2-hydroxyphenylacetate methyl, liquid (2.6g,57%). |
Last Update：2024-04-09 21:11:58
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View History
CYCLOHEXYLMANDELIC ACID METHYL ESTER
Polybenzimidazole
[VMIm]MS
2-[1-(3,4-DIMETHOXY-PHENYL)-ETHYL]-2H-PYRAZOL-3-YLAMINE
Cyclo[2,3-didehydroalanyl-L-alanyl-(2S)-2-hydroxy-4-methylpentanoyl-5-phenyl-L-norvalyl] (9CI)
Cyclobutanecarboxylic acid, 2-amino-, methyl ester, (1R,2S)- (9CI)
alpha(sup1),alpha(sup3),2-trihydroxymesitylene
1-[(4-chlorophenoxy)methyl]-1H-pyrazole-5-carbohydrazide
1(2H)-Chrysenone, 3,4,4a,4b,5,6,10b,11,12,12a-decahydro-8-methoxy-, [4aS-(4aα,4bβ,10bα,12aβ)]- (9CI)
氟米龙杂质4
Polybenzimidazole
[VMIm]MS
2-[1-(3,4-DIMETHOXY-PHENYL)-ETHYL]-2H-PYRAZOL-3-YLAMINE
Cyclo[2,3-didehydroalanyl-L-alanyl-(2S)-2-hydroxy-4-methylpentanoyl-5-phenyl-L-norvalyl] (9CI)
Cyclobutanecarboxylic acid, 2-amino-, methyl ester, (1R,2S)- (9CI)
alpha(sup1),alpha(sup3),2-trihydroxymesitylene
1-[(4-chlorophenoxy)methyl]-1H-pyrazole-5-carbohydrazide
1(2H)-Chrysenone, 3,4,4a,4b,5,6,10b,11,12,12a-decahydro-8-methoxy-, [4aS-(4aα,4bβ,10bα,12aβ)]- (9CI)
氟米龙杂质4
Raw Materials for CYCLOHEXYLMANDELIC ACID METHYL ESTER
Methyl benzilate
IODOCYCLOHEXANE
Bromocyclohexane
CYCLOHEXYLMAGNESIUM BROMIDE
(TRIMETHYLSILYL)DIAZOMETHANE
IODOCYCLOHEXANE
Bromocyclohexane
CYCLOHEXYLMAGNESIUM BROMIDE
(TRIMETHYLSILYL)DIAZOMETHANE