CHLORPROMAZINE EP IMPURITY A (CHLORPROMAZINE SULFOXIDE)
Chlorpromazine Sulfoxide
CAS: 969-99-3
Molecular Formula: C17H19ClN2OS
CHLORPROMAZINE EP IMPURITY A (CHLORPROMAZINE SULFOXIDE) - Names and Identifiers
CHLORPROMAZINE EP IMPURITY A (CHLORPROMAZINE SULFOXIDE) - Physico-chemical Properties
| Molecular Formula | C17H19ClN2OS |
| Molar Mass | 334.86 |
| Density | 1.35±0.1 g/cm3(Predicted) |
| Melting Point | 115° |
| Boling Point | 502.6±50.0 °C(Predicted) |
| Solubility | Chloroform (Sparingly), Methanol (Slightly) |
| Appearance | neat |
| Color | Off-White to Brown |
| pKa | pKa 9.0 (Uncertain) |
| Storage Condition | Refrigerator, Under Inert Atmosphere |
CHLORPROMAZINE EP IMPURITY A (CHLORPROMAZINE SULFOXIDE) - Risk and Safety
| UN IDs | UN 2811 6.1 / PGIII |
| Toxicity | LD50 s.c. in mice: 102 mg/kg (Minami, Yoshimoto) |
CHLORPROMAZINE EP IMPURITY A (CHLORPROMAZINE SULFOXIDE) - Reference Information
| Overview | Chlorpromazine (Chlorpromazine) is a class of phenothiazines, a central dopamine receptor blocker that acts on the central nervous system, with antipsychotic, cooling, vomiting, hypnosis, anesthesia and other pharmacological effects. It is mainly used as a sedative in veterinary clinic. In recent years, driven by interests, some people add chlorpromazine to feed and drinking water without permission to achieve the effect of sedation and hypnosis, thus indirectly playing the role of fattening and promoting growth; Or in the process of transportation, in order to reduce the weight loss and stress death, prevent the decline of meat quality, often large doses of chlorpromazine, especially before slaughter, a large number of use of chlorpromazine, can cause chlorpromazine residues in livestock and poultry products. Chlorpromazine in the body mainly through the liver metabolism, most of the exclusion from the urine, but due to the slow discharge, easy to produce accumulation in the body, residual in animal tissues for several months. |
| Application | The EU banned chlorpromazine in feed (EC) No. 17/97 as early as 1997; china's Ministry of Agriculture Announcement No. 176 (2002) also clearly states: it is strictly prohibited to add chlorpromazine in animal feed and drinking water; Ministry of Agriculture Announcement No. 235 (2002) also states: allow the therapeutic effect of chlorpromazine, however, it should not be detected in animal products. Oxychlorpromazine is an impurity of chlorpromazine. |
| indication | chlorpromazine is a representative drug of phenothiazine class, which has Antipsychotic effect. Enhance the role of hypnosis, anesthesia, sedative, anti emetic effect, cooling effect, and can block the peripheral alpha-adrenergic receptors, the endocrine system also has a certain impact. For the treatment of mental illness, can control schizophrenia or other psychiatric excitement agitation, Nervousness anxiety, hallucinations, delusions and other symptoms, the symptoms of depression and the efficacy of the symptoms of stiffness is poor. |
| adverse reactions | The main adverse reactions of oxychlorpromazine were dry mouth, blurred vision, upper abdominal discomfort, Fatigue, drowsiness, constipation, palpitations, occasional lactation, breast enlargement, obesity, amenorrhea, etc.; May also occur rash, asthma and other allergic reactions. To this end, there is a history of allergies, liver dysfunction, uremia and hypertension patients with caution. Severe liver dysfunction, history of epilepsy, Coma patients and glaucoma patients disabled. |
Last Update：2024-04-09 20:02:46
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CAS: 969-99-3
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CAS: 969-99-3
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CHLORPROMAZINE EP IMPURITY A (CHLORPROMAZINE SULFOXIDE)
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