Name | Bromomethylpyridine |
Synonyms | 4-Meth yihebio 3-BROMO-4-PICOLINE 3-Bromo-4-picoline Bromomethylpyridine 4-METHYL-3-BROMOPYRIDINE 4-Methyl-3-Bromopyridine 3-BROMO-4-METHYLPYRIDINE 3-Bromo-4-methylpyridine |
CAS | 3430-22-6 |
EINECS | 608-967-6 |
InChIKey | GSQZOLXWFQQJHJ-UHFFFAOYSA-N |
Molecular Formula | C6H6BrN |
Molar Mass | 172.02 |
Density | 1.549g/mLat 25°C(lit.) |
Boling Point | 199-200°C(lit.) |
Flash Point | 175°F |
Solubility | Chloroform, Methanol |
Appearance | Liquid |
Specific Gravity | 1.549 |
Color | Clear colorless to yellow |
BRN | 878354 |
pKa | 3.54±0.18(Predicted) |
Storage Condition | Inert atmosphere,Room Temperature |
Refractive Index | n20/D 1.56(lit.) |
Physical and Chemical Properties | Colorless transparent liquid |
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S2636 - |
UN IDs | Cool, dry,tightly closed |
WGK Germany | 3 |
HS Code | 29339900 |
Hazard Class | IRRITANT |
Packing Group | III |
application | 4-methyl -3-bromopyridine is an important intermediate, mainly used as pharmaceutical intermediate, organic synthesis intermediate, organic solvent, and also used in the production of dyes, fragrances and pesticides. |
preparation | under the cooling of ice salt bath, 2-methyl -4-aminopyridine (10.8g,0.1mol) is added to 48% HBr(46ml,0.4mol), after adding, cooling to -5 ℃, slowly adding bromine (15ml,0.3mol) dropwise, and adding 30-35min, then 42g of 40% sodium nitrite solution is added dropwise below 0 ℃, the addition is completed within 1-1.1h, the addition is continued to be stirred below 0 ℃ for 30min, then 50% sodium hydroxide solution is slowly added below 20 ℃ to adjust the pH of the solution to 9, the reaction liquid is extracted with ethyl acetate, the base layer is dried with anhydrous sodium sulfate, filtered and concentrated to obtain 4-methyl -3-bromopyridine with a molar yield of 95%. |