Boc-Hyp(Bzl)-OH·DCHA
boc-O-benzyl-L-hydroxyproline
CAS: 54631-81-1
Molecular Formula: C17H23NO5
Boc-Hyp(Bzl)-OH·DCHA - Names and Identifiers
| Name | boc-O-benzyl-L-hydroxyproline |
| Synonyms | BOC-HYP(BZL)-OH Boc-Hyp(Bzl)-OH Boc-Hyp(Bzl)-OH·DCHA Boc-L-Hyp(Bzl)-OH·DCHA boc-O-benzyl-L-hydroxyproline (4R)-1-Boc-4-(phenylmethoxy)-L-proline T-BUTYLOXYCARBONYL-O-BENZYL-L-HYDROXYPROLINE (4R)-4-(benzyloxy)-1-(tert-butoxycarbonyl)-L-proline 4-hydroxypyrrolidine-1,2-dicarboxylic acid O1-tert-butyl ester O2-(phenylmethyl) ester |
| CAS | 54631-81-1 |
| InChI | InChI=1/C17H23NO5/c1-17(2,3)23-16(21)18-10-13(9-14(18)15(19)20)22-11-12-7-5-4-6-8-12/h4-8,13-14H,9-11H2,1-3H3,(H,19,20)/t13-,14+/m1/s1 |
Boc-Hyp(Bzl)-OH·DCHA - Physico-chemical Properties
| Molecular Formula | C17H23NO5 |
| Molar Mass | 321.37 |
| Density | 1.21±0.1 g/cm3(Predicted) |
| Melting Point | ~70°C |
| Boling Point | 461.3±45.0 °C(Predicted) |
| Flash Point | 232.812°C |
| Vapor Presure | 0mmHg at 25°C |
| BRN | 5296858 |
| pKa | 3.75±0.40(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.557 |
| MDL | MFCD00037325 |
Boc-Hyp(Bzl)-OH·DCHA - Risk and Safety
| WGK Germany | 3 |
Boc-Hyp(Bzl)-OH·DCHA - Introduction
boc-O-benzyl-L-hydroxyproline(boc-O-benzyl-L-hydroxyproline) is an organic compound.
Nature:
The compound is a white crystalline solid with benzoate and hydroxyl functional groups. It is stable at room temperature, but decomposes when heated or in contact with strong bases.
Use:
boc-O-benzyl-L-hydroxyproline are commonly used in organic synthesis and drug development, mainly for the synthesis of peptides and related drugs. It serves as a protecting group capable of protecting the hydroxyl function of proline for selective reaction when desired. At the same time, it can also be used as a chiral inducer.
Preparation Method:
The preparation of boc-O-benzyl-L-hydroxyproline is usually carried out by a multi-step synthesis method. The general procedure involves the reaction of L-proline with benzyl alcohol to form an esterified product, the addition of benzyl peroxide for benzylation, and finally the introduction of a tert-butoxycarbonyl protecting group by acetylation. The specific preparation method can refer to the relevant literature or patent.
Safety Information:
boc-O-benzyl-L-hydroxyproline are chemicals and should be handled with caution. It may cause irritation to the eyes, skin and respiratory tract, so direct exposure should be avoided at the time of contact, and appropriate protective measures should be taken, such as wearing gloves, goggles and protective clothing. In addition, the operation should be carried out in a well-ventilated place. Its storage and handling must follow the relevant safety procedures. For detailed safety information, it is recommended to consult the relevant Safety Data Sheet (SDS) of the substance. When used in the laboratory, the correct laboratory operating instructions should be followed.
Nature:
The compound is a white crystalline solid with benzoate and hydroxyl functional groups. It is stable at room temperature, but decomposes when heated or in contact with strong bases.
Use:
boc-O-benzyl-L-hydroxyproline are commonly used in organic synthesis and drug development, mainly for the synthesis of peptides and related drugs. It serves as a protecting group capable of protecting the hydroxyl function of proline for selective reaction when desired. At the same time, it can also be used as a chiral inducer.
Preparation Method:
The preparation of boc-O-benzyl-L-hydroxyproline is usually carried out by a multi-step synthesis method. The general procedure involves the reaction of L-proline with benzyl alcohol to form an esterified product, the addition of benzyl peroxide for benzylation, and finally the introduction of a tert-butoxycarbonyl protecting group by acetylation. The specific preparation method can refer to the relevant literature or patent.
Safety Information:
boc-O-benzyl-L-hydroxyproline are chemicals and should be handled with caution. It may cause irritation to the eyes, skin and respiratory tract, so direct exposure should be avoided at the time of contact, and appropriate protective measures should be taken, such as wearing gloves, goggles and protective clothing. In addition, the operation should be carried out in a well-ventilated place. Its storage and handling must follow the relevant safety procedures. For detailed safety information, it is recommended to consult the relevant Safety Data Sheet (SDS) of the substance. When used in the laboratory, the correct laboratory operating instructions should be followed.
Last Update：2024-04-09 21:11:58
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View History
Boc-Hyp(Bzl)-OH·DCHA
N-[1-(5-{[2-(2-fluoroanilino)-2-oxoethyl]sulfanyl}-4-methyl-4H-1,2,4-triazol-3-yl)-2-methylpropyl]-3-methylbenzamide
6-Bromo-2-(4-methylphenyl)imidazo[1,2-a]pyridine
21609-90-5
342577-38-2
185759-14-2
rac 13-(E/Z)-3-Hydroxy Retinonitrile
1-(methylcarbamoyl)cyclopropane-1-carboxylic acid
8-Bromo-2,6-dimethylimidazo[1,2-a]pyridin-3-amine
5-Amino-1-(prop-2-en-1-yl)-1,2-dihydropyridin-2-one
N-[1-(5-{[2-(2-fluoroanilino)-2-oxoethyl]sulfanyl}-4-methyl-4H-1,2,4-triazol-3-yl)-2-methylpropyl]-3-methylbenzamide
6-Bromo-2-(4-methylphenyl)imidazo[1,2-a]pyridine
21609-90-5
342577-38-2
185759-14-2
rac 13-(E/Z)-3-Hydroxy Retinonitrile
1-(methylcarbamoyl)cyclopropane-1-carboxylic acid
8-Bromo-2,6-dimethylimidazo[1,2-a]pyridin-3-amine
5-Amino-1-(prop-2-en-1-yl)-1,2-dihydropyridin-2-one