Molecular Formula | C7H8N2O2 |
Molar Mass | 152.15 |
Density | 1.254 |
Melting Point | 117-119℃ |
Boling Point | 298℃ |
Flash Point | 134℃ |
pKa | 8.36±0.10(Predicted) |
Storage Condition | 2-8°C(protect from light) |
Application | p-nitrobenzylamine can be used as pharmaceutical synthesis intermediates, and organic synthesis intermediates, used in laboratory research and development and organic synthesis process. |
preparation | p-nitrobenzylamine was prepared as follows: add 155g of quaternary ammonium chloride, 150g of water, 320 grams of methanol, 300 grams of concentrated hydrochloric acid (36%), slowly heated to a little reflux (about 62 degrees) for 2.5 hours. The dimethoxymethane and methanol were distilled off, cooled to room temperature with water, added with 200 of ethyl acetate, and neutralized with 30% of liquid alkali under ice cooling until the pH value of the material was greater than 10. The layers were separated at rest, and the aqueous layer was extracted twice with ethyl acetate. The extracts were combined, dried with sodium sulfate, and filtered. The filtrate was distilled off ethyl acetate to give 70g (92%, based on p-nitrobenzyl chloride) of p-nitrobenzylamine at a GC analysis of about 98%. |