Name | Bacitracin |
Synonyms | Ayfivin Agfivin ayfivin Citracin Altracin baci-jel Zutracin baciguent ak-tracin Baciquent Penitracin Bacitracin baciliquin Topitracin ai3-50147-x bacitekointment bacitracine(french) cyclo[N~6~-(N-{[2-(1-amino-2-methylbutyl)-4,5-dihydro-1,3-thiazol-4-yl]carbonyl}leucyl-alpha-glutamylisoleucyl)-N~2~-asparaginyllysylornithylisoleucylphenylalanylhistidyl-alpha-aspartyl] (4R)-4-[[(2S)-2-[[2-[(1S)-1-amino-2-methyl-butyl]4,5-dihydrothiazole-5-carbonyl]amino]-4-methyl-pentanoyl]amino]-5-[[(1S)-1-[[(3S,6R,9S,12R,15S,18R,21S)-3-(2-amino-2-oxo-ethyl)-18-(3-aminopropyl)-12-benzyl-6-(carboxymethyl)-9-(3H-imidazol-4-ylmethyl)-2,5,8,11,14,17,20-heptaoxo-15-sec-butyl-1,4,7,10,13,16,19-heptazacyclopentacos-21-yl]carbamoyl]-2-methyl-butyl]amino]-5-oxo-pentanoic acid |
CAS | 1405-87-4 |
EINECS | 215-786-2 |
InChI | InChI=1/C66H103N17O16S/c1-9-35(6)52(69)66-72-32-48(100-66)63(97)80-43(26-34(4)5)59(93)75-42(22-23-50(85)86)58(92)83-53(36(7)10-2)64(98)76-40-20-15-16-25-71-55(89)46(29-49(68)84)78-62(96)47(30-51(87)88)79-61(95)45(28-39-31-70-33-73-39)77-60(94)44(27-38-18-13-12-14-19-38)81-65(99)54(37(8)11-3)82-57(91)41(21-17-24-67)74-56(40)90/h12-14,18-19,31,33-37,40-48,52-54H,9-11,15-17,20-30,32,67,69H2,1-8H3,(H2,68,84)(H,70,73)(H,71,89)(H,74,90)(H,75,93)(H,76,98)(H,77,94)(H,78,96)(H,79,95)(H,80,97)(H,81,99)(H,82,91)(H,83,92)(H,85,86)(H,87,88)/t35?,36?,37?,40-,41+,42+,43-,44+,45-,46-,47+,48?,52-,53-,54-/m0/s1 |
Molecular Formula | C66H102N17O16S |
Molar Mass | 1421.68538 |
Density | 1.0166 (rough estimate) |
Melting Point | 221-225°C |
Boling Point | 1755.5°C at 760 mmHg |
Flash Point | 1015.5°C |
Water Solubility | soluble |
Solubility | H2O: 50mg/mL, clear to very slightly hazy, deep yellow |
Vapor Presure | 0mmHg at 25°C |
Appearance | Crystallization |
Color | white to faintly beige |
Odor | odorlessor slt odor |
Merck | 13,936 |
Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
Sensitive | Easily hygroscopic and `sensitive` to air |
Refractive Index | 1.6700 (estimate) |
MDL | MFCD00062640 |
Physical and Chemical Properties | Melting point 221-225°C An antibiotic extracted from the fermentation broth of Bacillus subtilis. White or off-white powder. Odorless or slightly odorless. Bitter in taste. Hygroscopic. Soluble in water, methanol and ethanol, insoluble in acetone, ether and chloroform. Its aqueous solution is prone to failure at room temperature. The dried product was stable. The commercial product is A mixture based on bacitracin A. It has inhibitory effect on Gram-positive bacteria. |
Use | Suitable for the treatment of colitis, abscess, acne, purulent skin disease, amikacin dysentery, Neisseria gonorrhoeae and meningococcal infection. It is toxic to the kidney. |
Hazard Symbols | Xn - Harmful |
Risk Codes | 20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36 - Wear suitable protective clothing. |
WGK Germany | 2 |
RTECS | CP0175000 |
FLUKA BRAND F CODES | 21 |
TSCA | Yes |
HS Code | 29419090 |
Toxicity | LD50 oral in guinea pig: 2gm/kg |
Reference Show more | 1. Zhu Zhihong, Xu Yanyang, Qiu Yang, et al. Optimization of Liquid Fermentation Process of Soybean-corn Compound Peptide [J]. Food Industry Technology, 2015. 2. Xu Yanyang, Huang Shengnan, Zheng Li. Optimization of Solid State Fermentation Process of Soybean-corn Compound Peptide [J]. Food Technology, 2015(04):127-136. 3. Gao Yanxiu, Jin Yong, xia Jingxia, et al. Preparation of bacitracin polybutyl cyanoacrylate nanoparticles [J]. Journal of Medicine, Yanbian University, 2013, 036(004):277-280. 4. Jin Jian, Ma Haile, Qu Wenjuan, et al. Effect of Ultrasonic Pretreatment on Enzymatic Hydrolysis of Corn Protein [J]. Chinese Journal of Cereals and Oil, 2015, 30(11):58-64. 5. [IF = 7.514] Chi Zhang et al."Identification of soybean peptides and their effect on the growth and metabolism of Limosilactobacillus reuteri LR08." Food Chem. 2022 Feb;369:130923 6. [IF = 7.514] Zhucheng Yin et al."Analysis of the interaction between cyanidin-3-O-glucoside and casein hydrolysates and its effect on the antioxidant ability of the complexes." Food Chem. 2021 Mar;340:127915 7. [IF = 4.451] Chi Zhang et al."Effects of soybean protein isolates and peptides on the growth and metabolism of Lactobacillus rhamnosus." J Funct Foods. 2021 Feb;77:104335 8. [IF = 4.411] Yaru Wu et al."Interaction of Soy Protein Isolate Hydrolysates with Cyanidin-3-O-Glucoside and Its Effect on the In Vitro Antioxidant Capacity of the Complexes under Neutral Condition." Molecules. 2021 Jan;26(6):1721 9. [IF = 5.396] Hongdong Song et al."Digestion characteristics of quinoa, barley and mungbean proteins and the effects of their simulated gastrointestinal digests on CCK secretion in enteroendocrine STC-1 cells." Food & Function. 2022 May;: |
This product is calculated according to the dry product, and the titer of each lmg shall not be less than 55 bacitracin units.
take the right amount of this product and the standard sample of bacitracin, respectively, with 1% ethylenediamine tetraacetic acid disodium solution made in each lml containing about 6.0 mg solution, as test solution and standard solution, according to thin layer chromatography (General 0502) test method, take 5ul of each of the above two solutions and put them on the same silica gel GF254 thin layer plate (activated at 105°C for 1~2 hours before use), and dry them naturally, N-butanol-glacial acetic acid-water-pyridine-ethanol (60:15:10:6:5) was used as the developing solvent, developed, dried, and sprayed with 1% ninhydrin butanol-pyridine (99:1) The solution was heated at 105°C for about 5 minutes to the appearance of brown-red spots. The position and color of the main spot displayed by the test solution should be the same as the position and color of the main spot of the standard solution.
precision weighing the appropriate amount of this product, with the quantitative preparation of sterile water per lml containing about 100 units of solution, according to the microbiological assay of antibiotics (General Principles 1201) determination.
antibacterial agents.
sealed and stored in a dry place.
This product containing bacitracin should be labeled amount of 90.0% ~ 120.0%.
This product is light yellow or yellow ointment.
take an appropriate amount of this product, add an appropriate amount of 1% ethylenediamine tetraacetic acid disodium solution, place it on a water bath, heat and stir to dissolve bacitracin, cool it, filter it, the filtrate is prepared into a solution containing about 500 bacitracin units per 1 ml as a test solution, A solution containing 500 bacitracin units per 1 ml was prepared by adding 1% ethylene diamine tetraacetic acid disodium solution. As a standard solution, the same results were obtained according to the identification method under the item of bacitracin.
should comply with the relevant provisions under ointment (General rule 0109).
take about 2g of this product, weigh it accurately, set it in a separatory funnel, add 20ml of ether without peroxide, shake to dissolve Vaseline, and use phosphate buffer (pH 6.0) extract 3 to 4 times, 10ml each time, combined extract, quantitative dilution with the above buffer to a certain concentration, according to the method under the item of bacitracin, that is obtained.
The same as bacitracin.
specification
8g(4000 units)
sealed and stored in a dry and cool place.
This product containing bacitracin should be labeled amount of 90.0% ~ 120.0%.
This product is light yellow or yellow oil.
take an appropriate amount of this product, add an appropriate amount of 1% ethylenediamine tetraacetic acid disodium solution, place it on a water bath, heat and stir to dissolve bacitracin, cool it, filter it, the filtrate is prepared into a solution containing about 500 bacitracin units per 1 ml as a test solution, A solution containing about 500 bacitracin units per 1 ml was prepared by adding 1% ethylene diamine tetraacetic acid disodium solution as a standard solution. The same results were shown according to the identification test under the item bacitracin.
should comply with the relevant provisions under Ophthalmic Preparations (General rule 0105).
take about 2g of this product, weigh it accurately, set it in a separatory funnel, add 20ml of ether without peroxide, shake to dissolve Vaseline, and use phosphate buffer (pH 6.0) extract 3 to 4 times, 10ml each time, combined extract, quantitative dilution with the above buffer to a certain concentration, according to the method under the item of bacitracin, that is obtained.
The same as bacitracin.
2G (1000 units)
sealed and stored in a dry, cool place.