BMP Inhibitor II, DMH1 Bulk
DMH 1
CAS: 1206711-16-1
Molecular Formula: C24H20N4O
BMP Inhibitor II, DMH1 Bulk - Names and Identifiers
BMP Inhibitor II, DMH1 Bulk - Physico-chemical Properties
| Molecular Formula | C24H20N4O |
| Molar Mass | 380.44 |
| Density | 1.24±0.1 g/cm3(Predicted) |
| Melting Point | 178 °C |
| Solubility | DMSO: soluble5mg/mL, clear (warmed) |
| Appearance | powder |
| Color | light yellow to orange |
| pKa | 3.34±0.46(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | DMH1 inhibit BMP signaling with IC50 of 100 nM, and selective inhibit the BMP-induced Smad1/5/8 activation. DMH1 increases cardiomyocyte progenitors and promotes cardiac differentiation in mouse embryonic stem cells. In addition, DMH1 as a BMP inhibitor, significant reductions NSCLC cell growth, migration and invasion. DMH1 inhibits BMP signaling with an IC50 of 100 nM and selectively inhibits BMP-induced Smad1/5/8 activation. DMH1 increases mouse embryonic stem cell cardiomyocyte progenitor cells and promotes myocardial differentiation. In addition, DMH1, as a BMP inhibitor, significantly reduced NSCLC cell growth, migration and invasion. |
| In vivo study | DMH1 dorsalizes the embryonic axis without disrupting the angiogenic process in zebrafish embryos. In proepicardial extracts, DMH1 results in the great inhibition of epiplasmatic sheet migration. DMH1 (5 mg/kg I. p.)attenuates Xeno raft lung tumor growth in mice bearing A549 Xeno raft. DMH1 dorsal the embryonic axis of zebrafish embryos without disrupting the angiogenic process. DMH1 causes the greatest inhibition of epithelial cell layer migration in the epicardial graft tissue. DMH1 (5 mg/kg I. p.) attenuated xenograft lung tumor growth in mice bearing A549 xenografts. |
BMP Inhibitor II, DMH1 Bulk - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | 25 - Toxic if swallowed |
| Safety Description | 45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| WGK Germany | 3 |
BMP Inhibitor II, DMH1 Bulk - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.629 ml | 13.143 ml | 26.285 ml |
| 5 mM | 0.526 ml | 2.629 ml | 5.257 ml |
| 10 mM | 0.263 ml | 1.314 ml | 2.629 ml |
| 5 mM | 0.053 ml | 0.263 ml | 0.526 ml |
Last Update：2024-01-02 23:10:35
BMP Inhibitor II, DMH1 Bulk - Reference Information
| biological activity | DMH1 is a selective BMP receptor inhibitor that inhibits ALK2 with an IC50 of 107.9 nM, KDR (VEGFR-2) and PDGFR had no inhibitory effect. DMH1 is a selective BMP receptor inhibitor that inhibits ALK2 with an IC50 of 107.9 nM and has no inhibitory effect on AMPK, ALK5, KDR (VEGFR-2) and PDGFR. DMH1 can inhibit autophagy. |
| in vitro study | DMH1 inhibit BMP signaling with IC50 of 100 nM, the BMP-induced Smad1/5/8 activation. DMH1 increases cardiomyocyte progenitors and promotes cardiac differentiation in mouse embryonic stem cells. In addition, DMH1 as a BMP inhibitor, significant reductions NSCLC cell growth, migration and invasion. DMH1 inhibits BMP signaling with an IC50 of 100 nM and selectively inhibits BM P-induced Smad1/5/8 activation. DMH1 increases mouse embryonic stem cell cardiomyocyte progenitor cells and promotes myocardial differentiation. In addition, DMH1, as a BMP inhibitor, significantly reduced NSCLC cell growth, migration and invasion. |
| in vivo study | DMH1 saldorizes the embylonic axis. In proepicardial extracts, DMH1 results in the great inhibition of epiplasmatic sheet migration. DMH1 (5 mg/kg I. p.)attenuates Xeno raft lung tumor growth in mice bearing A549 Xeno raft. DMH1 dorsal the embryonic axis of zebrafish embryos without disrupting the angiogenic process. DMH1 causes the greatest inhibition of epithelial cell layer migration in the epicardial graft tissue. DMH1 (5 mg/kg I. p.) attenuated xenograft lung tumor growth in mice bearing A549 xenografts. |
| Target | TargetValue ALK2 (Cell-free assay) 107.9 nM |
| Target | Value |
| ALK2 (Cell-free assay) | 107.9 nM |
Last Update：2024-04-10 22:29:15
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CAS: 1206711-16-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: DMH1 Visit Supplier Webpage Request for quotationCAS: 1206711-16-1
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple SpecificationsSpot supply
Product Name: DMH-1 Visit Supplier Webpage Request for quotationCAS: 1206711-16-1
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: DMH 1 Visit Supplier Webpage Request for quotationCAS: 1206711-16-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Product Name: DMH 1 Visit Supplier Webpage Request for quotation
CAS: 1206711-16-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 1206711-16-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
BMP Inhibitor II, DMH1 Bulk
2-甲氧基-5-(2-硝基乙烯基)苯酚
1-(5-(苄氧基)-2-羟基-3-硝基苯基)-乙酮
methyltriphenylphosphonium, salt with 2-cyclohexylphenol (1:1)
4,6-二氯-5-乙基-2-(甲基磺酰基)嘧啶
4-碘-1-丁炔
6-三氟甲磺酰基-1H-1,3-苯并二唑-1-醇
芴甲氧羰酰基-6-氨基己酸
4,6-二氯-5-异丙基嘧啶
4-氯-7,7-二甲基-5,6,7,8-四氢喹唑啉
2-甲氧基-5-(2-硝基乙烯基)苯酚
1-(5-(苄氧基)-2-羟基-3-硝基苯基)-乙酮
methyltriphenylphosphonium, salt with 2-cyclohexylphenol (1:1)
4,6-二氯-5-乙基-2-(甲基磺酰基)嘧啶
4-碘-1-丁炔
6-三氟甲磺酰基-1H-1,3-苯并二唑-1-醇
芴甲氧羰酰基-6-氨基己酸
4,6-二氯-5-异丙基嘧啶
4-氯-7,7-二甲基-5,6,7,8-四氢喹唑啉