Molecular Formula | C10H15NO |
Molar Mass | 165.23 |
Density | 1.0203 (rough estimate) |
Melting Point | 102°C |
Boling Point | 293.09°C (rough estimate) |
Flash Point | 158.3°C |
Solubility | DMSO : ≥ 100 mg/mL (605.22 mM);H2O : < 0.1 mg/mL (insoluble) |
Vapor Presure | 0.000845mmHg at 25°C |
Appearance | White to off-white (Solid) |
Color | Very sweet crystals |
pKa | 11.45±0.28(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
Refractive Index | 1.5200 (estimate) |
MDL | MFCD00019421 |
In vitro study | The responses of the monomeric Tas1r2 subunits of human, rhesus monkey, squirrel monkey and mouse to Perillartine are examined, respectively. The human, rhesus monkey and squirrel monkey Tas1r2 subunits can be activated by Perillartine, while mouse Tas1r2 can not. The insensitivity of human, rhesus monkey, squirrel monkey and mouse Tas1r2 subunits to cyclamate precludes the probable involvement of Tas1r3 subunit in the assay. Replacement of the mouse Tas1r2 with rhesus monkey Tas1r2 (rhTas1r2/mTas1r3) leads to a gain of response to Perillartine. The dose-response curve show the efficacy of responses of the Tas1r2 subunits among species: hTAS1R2>rhTas1r2>smTas1r2>mTas1r2. These results demonstrate that the monomeric Tas1r2 subunit can be activated by Perillartine in a species-dependent manner. |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
Toxicity | LD50 orl-rat: 2500 mg/kg AFDOAQ 15,82,51 |