6-Chloro-5-(trifluoromethyl)pyridin-3-amine is an organic compound whose chemical formula is C6H3ClF3N.
The main properties of the compound are as follows:
-Appearance: White crystalline powder;
-Melting point: 86-89°C;
-Boiling point: 156-158°C;
-Density: 1.66g/cm³.
6-Chloro-5-(trifluoromethyl)pyridin-3-amine has a wide range of applications:
-As a pesticide intermediate: the compound can be used to synthesize pesticides, such as pesticides, herbicides, etc;
-As a drug intermediate: It can also be used as an intermediate for the synthesis of drugs and drug candidate compounds;
-for organic synthesis: it can be used in organic synthesis reaction of ammoniation reaction, substitution reaction, etc.
Regarding the preparation method, a common preparation method is obtained by the following reaction:
First, 6-chloropyridine is reacted with trifluoroacetyl chloride (trifluoroacetyl chloride) to form 5-(trifluoromethyl)-6-chloropyridine. Then, the resulting compound is reacted with ammonia gas to produce 6-Chloro-5-(trifluoromethyl)pyridin-3-amine by nucleophilic substitution.
When using or handling 6-Chloro-5-(trifluoromethyl)pyridin-3-amine, you need to pay attention to the following safety information:
-This is an organic compound with certain toxicity and irritation. Protective gloves and safety glasses should be worn;
-Avoid inhaling the dust or vapor of the compound, and operate in a well-ventilated place;
-Avoid direct contact with skin, eyes, etc., such as accidental contact should immediately rinse with water and seek medical treatment;
-Waste disposal shall be carried out in accordance with relevant regulations.
Please understand and follow the safety procedures before use.