Name | Nicotinamide |
Synonyms | VB3 VPP Vitamin PP Vitamin B3 Niacinamide Nicotinamide Nicotinamidum Nicotinic Amide Nicotinic acid amide Nicotinamide (1.06818) Pyridine-3-carboxamide 3-Pyridinecarboxyamide NicotinamideB.P.,U.S.P. Pyridine-3-Carboxyamide NIACINAMIDE USP GRANULAR NicotinamideForBiochemistry niacinamide cell culture tested |
CAS | 98-92-0 |
EINECS | 202-713-4 |
InChI | InChI=1/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) |
InChIKey | DFPAKSUCGFBDDF-UHFFFAOYSA-N |
Molecular Formula | C6H6N2O |
Molar Mass | 122.12 |
Density | 1.40 |
Melting Point | 128-131°C(lit.) |
Boling Point | 150-160 °C |
Flash Point | 182 °C |
Water Solubility | 1000 g/L (20 ºC) |
Solubility | 17g/L water (20°C); Slightly soluble in ethanol (10g/L 20°C), easily soluble in boiling water, boiling alcohol, soluble in propylene glycol, chloroform, hydroxide and carbonate solutions, insoluble in ether and lipid solvents. |
Vapor Presure | 0Pa at 25℃ |
Vapor Density | 4.22 (vs air) |
Appearance | White powder |
Color | white |
Odor | Odorless |
Merck | 14,6523 |
BRN | 383619 |
pKa | 3.3(at 20℃) |
PH | 6.0-7.5 (50g/l, H2O, 20℃) |
Storage Condition | 2-8°C |
Stability | Stable. Incompatible with strong oxidizing agents. |
Sensitive | Sensitive to light |
Refractive Index | 1.4660 (estimate) |
MDL | MFCD00006391 |
Physical and Chemical Properties | Melting Point 128-131°C boiling point 150-160°C flash point 182°C water-soluble 1000g/L (20°C) |
Use | Vitamin drugs, involved in metabolic processes in the body, for the prevention and treatment of pellagra and other niacin deficiency |
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. S7 - Keep container tightly closed. |
UN IDs | UN1230 - class 3 - PG 2 - Methanol, solution |
WGK Germany | 1 |
RTECS | QS3675000 |
FLUKA BRAND F CODES | 8 |
TSCA | Yes |
HS Code | 29362990 |
Toxicity | LD50 s.c. in rats: 1.68 g/kg (Brazda, Coulson) |
Reference Show more | 1. Dong Xiaolin Lu Hongke Peng Tao et al. Optimization of processing technology of cooked buckwheat rice by response surface methodology [J]. Grain and Oil Processing (electronic version) 2015 000(006):51-55. 2. Wan Yuping, Zhou Xiaohua, Feng Lin, et al. Preparation and characterization of glutathione-chromium-nicotinic acid chelate [J]. Amino acids and biological resources, 2015, 37(1):49-55. 3. Wang Yue, Li Dongxia, Li Zhi, et al. Detection of vitamin B based on four-peak metamaterial THz sensor [J]. Spectroscopy and spectral analysis, 2020, v.40(06):131-136. 4. Dong Shujia, Qin, Wei, Shuai, Liu, canzhen, et al. Effect of low nitrogen on ester synthesis in fermentation of Saccharomyces cerevisiae [J]. China brewing 2018 037(001):149-154. 5. Wen Pengcheng, Cui Na, Liang Qi, etc. Changes of vitamins in yak colostrum and its transitional milk [J]. Science and Technology of food industry, 2014, 35(16):121-121. 6. Chen Yinbin, Wang Yufang, Hou Zhifang et al. Effects of Rg1 combined with B vitamins on NO release and Rg1 brain volume in mice with acute myocardial ischemia [J]. Specialty Research 2016(1):5-8. 7. Guo, Hu Xiaojing, Xu Rong, et al. Effects of drying methods on nutrition, functional components and amino acid composition of Moringa oleifera leaves [J]. Food Science, 2018, 39(011):39-45. 8. Zhao Xin, Liang Kehong, Zhu Hong, Liu Li, Wang Jing. Comparative study on nutritional quality and flavor compounds of different varieties of pear [J]. Journal of Food Safety and quality testing, 2020,11(21):7797-7805. 9. Zheng, Peihe, et al. "Influence of B- complex vitamins." Journal of medicinal food 20.11 (2017):-1132.https:// doi.org/10.1089/jmf.2017.3922 10. Chen, Yin Bin, et al. "Effect of B- complex vitamins on the antifatigue activity and bioavailability of ginsenoside Re after oral administration." Journal of ginseng research 41.2 (2017): 209-214.https://doi.org/10.1016/j.jgr.2016.03.006 11. [IF=6.06] Yin Bin Chen et al."Effect of B- complex vitamins on the antifatigue activity and bioavailability of ginsenoside Re after oral administration."J Ginseng Res. 2017 Apr;41:209 12. [IF=2.786] Peihe Zheng et al."Influence of B- Complex Vitamins on the Pharmacokinetics of Ginsenosides Rg1, Rb1, and Ro After Oral Administration."J Med Food. 2017 Nov;20(11):1127-1132 13. [IF=5.165] Chun-Yan Zhang et al."Vitamin B3 as a high acid-alkali tolerant peroxidase mimic for colorimetric detection of hydrogen peroxide and glutathione."Arab J Chem. 2022 Jun;15:103823 14. [IF=2.391] Wu Zhihao et al."Preparation of Monascus-fermented ginkgo seeds: optimization of fermentation parameters and evaluation of bioactivity."FOOD SCIENCE AND BIOTECHNOLOGY. 2022 Apr;:1-10 |
White needle-like crystals or powders. Bitter in taste. The melting point was 129-131 °c. 1g of the product is soluble in 1mL water, 1.5 ml alcohol and 10 ml glycerol, insoluble in ether.
from nicotinic acid and ammonia salt after dehydration.
This product is 3-pyridinecarboxamide. The content of C6H6N20 shall not be less than 99.0% calculated as dried product.
The melting point of this product (General 0612) is 128~131°C.
is an essential nutrient for mammals. Water solubility is better than nicotinic acid, but easy to form complexes with vitamin C and caking. Dosage 30~80mg/kg.
This product l .O g, add water 10ml to dissolve, according to the law (General 0631),p H value is 5. 5~7. 5.
take this product l.O g, add water to dissolve after 10ml, check according to law (General rule 0901 and general rule 0902), the solution should be clear and colorless.
take 0.20g of this product, check according to law (General rule 0842), and control solution (take 1.0 of cobalt chloride solution for color comparison, ml of potassium dichromate solution for color comparison, colorimetric copper sulfate liquid l_0 m l, diluted with water to 50ml) 5 m l comparison, not deeper.
take this product, precision weighing, adding ethanol to dissolve and dilute to make a solution containing about 40mg per lm l, as a test solution; Take the appropriate amount of precision, diluted separately with ethanol to make about 0.2mg and 0. lm g solution, as a control solution (1) and (2 ) ; Another appropriate amount of nicotinic acid control, and ethanol dissolved and diluted to make about 0.2M g of solution, as a reference solution; Then take the appropriate amount of nicotinic acid control and this product, add ethanol to dissolve and dilute to make about 1 l/l containing nicotinic acid 0. A mixed solution of 2m g and 1 m g of nicotinamide was used as a control solution (3). According to the thin layer chromatography (General 0502) test, draw 5M1 of each of the above five solutions, respectively, on the same silica gel GF254 thin layer plate, with chloroform-absolute ethanol-water (48 : 45: 4) for the development of the agent, expand, take out, dry, set the UV light (254mn) under the inspection. The control solution (3> should show two clearly separated spots; The control solution (2) should show one clearly visible spot; The test solution should show impurity spots corresponding to the control solution, its color with the
The main spot of the irradiated solution should not be deeper (0.5%); If other impurity spots are shown, it should not be deeper compared with the main spot of the control solution (1).
take this product, put it in a phosphorus pentoxide dryer, and dry it under reduced pressure for 18 hours. The weight loss shall not exceed 0.5% (General rule 0831).
not over 0841 (general rule).
take this product l .O g, Add 10ml of water to dissolve, add 6m l of lm o L/l hydrochloric acid solution and an appropriate amount of water to make 2 5 m l, and check according to law (General Principles 0821 first law), heavy metals should not be more than 20 parts per million.
take l .O g of this product, add 2 M l of water and 5m l of hydrochloric acid to dissolve it, and then check it according to law (General rule 0822 first law), and it shall comply with the regulations (0.0002%).
take this product about O.lg, precision weighing, after adding 20ml of glacial acetic acid to dissolve, add acetic anhydride 5M l and crystal violet indicator solution 1 drop, with perchloric acid titration solution (O. 1 mol/L) titration to the solution is blue-green, and the results are corrected with a blank test. Each lm l of high gas acid titration solution (0.1 M o l/L) corresponds to 12.21 mg of C6H6N20.
pharmaceutical excipients, cosolvents and stabilizers.
light-shielding and closed storage.