Molecular Formula | C5H7NO3 |
Molar Mass | 129.11 |
Density | 1.3816 (rough estimate) |
Melting Point | 160-163°C(lit.) |
Boling Point | 239.15°C (rough estimate) |
Specific Rotation(α) | -27.5 º (c=10, 1 N NaOH) |
Flash Point | 227.8°C |
Water Solubility | 10-15 g/100 mL (20 ºC) |
Solubility | Soluble in water, alcohol, acetone and glacial acetic acid, slightly soluble in ethyl acetate, insoluble in ether. |
Vapor Presure | 0.002Pa at 25℃ |
Appearance | White fine crystal |
Color | White to off-white |
Merck | 14,8001 |
BRN | 82132 |
pKa | 3.32(at 25℃) |
PH | 1.7 (50g/l, H2O, 20℃) |
Storage Condition | 2-8°C |
Stability | Stable. Incompatible with bases, acids, strong oxidizing agents. |
Refractive Index | -10 ° (C=5, H2O) |
MDL | MFCD00005272 |
Physical and Chemical Properties | Melting point 152-162°C specific optical rotation -27.5 ° (c = 10, 1 N NaOH) water-soluble 10-15g/100 mL (20°C) |
Use | Used in food, medicine, cosmetics and other industries |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection |
WGK Germany | 3 |
RTECS | TW3710000 |
FLUKA BRAND F CODES | 21 |
TSCA | Yes |
HS Code | 29337900 |
Hazard Class | IRRITANT |
Reference Show more | 1. [IF=1.902] Zhi Rao et al."Multicomponent determination of traditional Chinese medicine preparation yin-zhi-huang injection by LC–MS/MS for screening of its potential bioactive candidates using HepaRG cells."Biomed Chromatogr. 2018 Feb;32(2):e4057 2. [IF=4.466] Yao Tan et al."Multiomics Integrative Analysis for Discovering the Potential Mechanism of Dioscin against Hyperuricemia Mice."J Proteome Res. 2021;20(1):645–660 3. [IF=4.142] Wang Chenxi et al."Systematic quality evaluation of Peiyuan Tongnao capsule by offline two-dimensional liquid chromatography/quadrupole-Orbitrap mass spectrometry and adjusted parallel reaction monitoring of quality markers."Anal Bioanal Chem. 2019 Nov;4 4. [IF=3.935] Biru Shi et al."Investigation on the stability in plant metabolomics with a special focus on freeze-thaw cycles: LC–MS and NMR analysis to Cassiae Semen (Cassia obtusifolia L.) seeds as a case study."J Pharmaceut Biomed. 2021 Sep;204:114243 |
oxidized proline is also known as L-pyroglutamic acid . Relative molecular mass 129.12. The melting point was 162-163 °c. Do not dissolve in ether, ethyl acetate-soluble, soluble in water (25 ° C 40), ethanol, acetone and acetic acid. Specific optical rotation -11.9 °(c = 2,H2O). Its sodium salt can be used as a moisturizing agent in cosmetics, its moisturizing effect is better than glycerol, sorbitol, non-toxic, no stimulating effect, for skin care and hair care cosmetics; This product has inhibitory effect on tyrosine oxidase, can prevent the deposition of melanin-like, has a whitening effect on the skin; Has a softening effect on the skin, can be used for nail cosmetics; Can also be used as a surfactant for detergents; Chemical reagents, for the resolution of racemic amines; Organic intermediates.
Chinese name
oxidized proline
foreign name
L-Pyroglutamic acid
alias
chemical formula
C5H7NO3
Molecular weight
129.12
CAS accession number
98-79-3
melting point
162~163℃
water-soluble
soluble in water (40 at 25 ℃)
from VIP Journal Professional Edition
Author:
Ma Dongsheng , high fly , Li Wei , Xiaojie , Zheng Yi male
Abstract:
with six years of fresh ginseng, Raw ginseng, red ginseng as the test material, the establishment of adenosine and L-pyroglutamic acid content determination method: RP-HPLC method for the analysis of adenosine content in samples, elite Hypersil ODS2(4.6mm × 250, 5 μm) column, mobile phase was methanol-water (10:90), flow rate was 0.8 mL/min, detection wavelength was 260 nm, the column temperature was 40 ℃; The content of L-pyroglutamic acid in the sample was analyzed by the first method, the COSMOSIL 5C18-PAQ (RP-HPLC ×, 5 μm) column, the mobile phase consisted of methanol -5 mmol/L sodium acetate aqueous solution (8:92) with a flow rate of 0.5 mL/min, a detection wavelength of 210 nm and a column temperature of 40 ℃. The contents of adenosine and L-pyroglutamic acid in fresh ginseng and its processed products were 0.332-0.457 mg/g and 0.315-1.056 mg/g, respectively. The results showed that the contents of adenosine and L-pyroglutamic acid changed regularly in fresh ginseng and its processed products. The contents of adenosine and L-pyroglutamic acid in fresh ginseng were the highest, followed by the processed products. Therefore, in terms of anti-diabetic activity, fresh ginseng should have more research value than its processed products.
Key words:
fresh ginseng; Raw ginseng; Red ginseng; Adenosine; L-pyroglutamic acid
cited:
year:
2013
from VIP
Author:
Abstract:
The reaction characteristics of L-pyroglutamic acid as chiral source are introduced, and the application of L-pyroglutamic acid as chiral source in asymmetric synthesis is reviewed.
Key words:
Asymmetric Synthesis of L-pyroglutamic acid chiral source
DOI:
10.3969/j.issn.0441-3776.1998.09.003
cited:
year:
1998
from VIP Journal Professional Edition
Author:
Abstract:
The components of L-pyroglutamic acid in Gastrodia elata Bl with different sources and processing methods were quantitatively analyzed by HPLC. The results showed that the content of L-pyroglutamic acid in Gastrodia elata was different due to different producing areas, cultivation methods and processing methods. The content of L-pyroglutamic acid in wild species and fresh products was higher than that in dry products.
Key words:
Gastrodia elata Blume L-pyroglutamic acid high performance liquid chromatography Traditional Chinese Medicine
cited:
year:
2000