Name | Eflornithine HCl |
Synonyms | DMFO HCl Eflornithine HCl DFMO EFLORNITHINE DFMO Eflornithine Eflornithine hydrochloride hydrate H-alpha-Difluoro-Me-DL-Orn-OH.HCl.H2O Eflornithine hydrochloride monohydrate H-alpha-Difluoro-Me-DL-Orn-OH . HCl . H2O 2,5-diamino-2-(difluoromethyl)pentanoic acid eflornithine,Eflornithinehydrochloridehydrate 2-(Difluoromethyl)ornithine hydrochloride hydrate |
CAS | 96020-91-6 62878-23-9 |
InChI | InChI=1/C6H12F2N2O2.ClH/c7-4(8)6(10,5(11)12)2-1-3-9;/h4H,1-3,9-10H2,(H,11,12);1H |
Molecular Formula | C6H15ClF2N2O3 |
Molar Mass | 236.64 |
Melting Point | >210°C (dec.) |
Solubility | Soluble in Water (up to 25 mg/ml). |
Appearance | White powder |
Color | White |
Merck | 14,3522 |
Storage Condition | Inert atmosphere,2-8°C |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months. |
Use | This product is for scientific research only and shall not be used for other purposes. |
In vitro study | Treatment of BY2 cells with α-difluoromethyl-Orn inhibited their hydrogen peroxide production, but did not undergo programmed cell death. |
In vivo study | Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension. |
RTECS | RM2981900 |
HS Code | 2922493800 |