944937-53-5 - Names and Identifiers
Name | 6-bromo-1H-pyrrolo[3,2-b]pyridine
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Synonyms | 6-bromo-4-azaindole 6-Bromo-4-azaindole 6-Bromo-1H-pyrrolo[3,2-b]... 6-BROMO-1H-PYRROLO[3,2-B]PYRIDINE 6-bromo-1H-pyrrolo[3,2-b]pyridine 6-BroMo-3aH-pyrrolo[3,2-b]pyridine 6-bromo-1H-pyrrolo[3,2-b]pyrridine 1H-Pyrrolo[3,2-b]pyridine,6-broMo- 1H-pyrrolo[3,2-b]pyridine, 6-bromo-
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CAS | 944937-53-5
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InChI | InChI=1/C7H5BrN2/c8-5-3-7-6(10-4-5)1-2-9-7/h1-4,9H |
InChIKey | OJFFFCVPCVATIV-UHFFFAOYSA-N |
944937-53-5 - Physico-chemical Properties
Molecular Formula | C7H5BrN2
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Molar Mass | 197.03 |
Density | 1.770 |
Boling Point | 311℃ |
Flash Point | 142℃ |
Vapor Presure | 0.00104mmHg at 25°C |
Appearance | Solid |
pKa | 13.73±0.40(Predicted) |
Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
Refractive Index | 1.727 |
MDL | MFCD09266227 |
944937-53-5 - Risk and Safety
Risk Codes | R22 - Harmful if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin.
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Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
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WGK Germany | 3 |
Hazard Class | IRRITANT |
944937-53-5 - Introduction
6-bromo-1H-yrrolo [3,2-b]pyridine is an organic compound with the chemical formula C8H5BrN2, which is a blue crystal or powder. The following is a description of the properties, uses, preparation and safety information of pyridine 6-bromo-1H-prrolo [3,2-b]:
Nature:
-Appearance: Blue crystal or powder
-Molecular weight: 214.05g/mol
-melting point: 72-74 ℃
-Boiling point: 376.58 ℃
-Solubility: Slightly soluble in water, soluble in most organic solvents
Use:
-6-bromo-1H-yrrolo [3,2-b]pyridine are often used in organic synthesis as intermediates or raw materials. It can be used to synthesize other nitrogen-containing heteroindoles, such as fluorescent dyes and photosensitive compounds.
-In the field of medicine, 6-bromo-1H-yrrolo [3,2-b]pyridine has also been studied for the synthesis of anticancer drugs.
Method:
- 6-bromo-1H-pyrrolo[3,2-b]pyridine can be obtained by reacting brominous fluoride with 4-azaindole. The specific steps are as follows: under the protection of phosgene, the bromide fluoride is dissolved in dichloromethane, and then 4-azaindole is added. After a period of reaction, the target product is purified by recrystallization or column chromatography.
Safety Information:
-6-bromo-1H-pirrolo [3,2-b]pyridine are organic halogen compounds, which are toxic and corrosive. Appropriate personal protective equipment such as gloves, glasses and lab clothes should be worn during operation.
-Avoid inhaling its dust or gas to avoid irritation or damage to the respiratory tract.
-Avoid contact with skin and eyes, rinse immediately with plenty of water if necessary, and seek medical attention.
-When storing and handling, it should be stored separately from dangerous items such as oxidants and strong acids to prevent accidents.
Last Update:2024-04-09 02:00:49