94220-38-9 - Names and Identifiers
Name | 7-chloro-5-methyl-1H-pyrazolo[4,3-b]pyridine
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Synonyms | LogP 7-chloro-5-methyl-1H-pyrazolo[4,3-b]pyridine 7-CHLORO-5-METHYL-1H-PYRAZOLO[4,3-B]PYRIDINE 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]pyridine 1H-pyrazolo[4,3-b]pyridine, 7-chloro-5-methyl- 1H-Pyrazolo[4,3-b]pyridine, 7-chloro-5-Methyl-
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CAS | 94220-38-9
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InChI | InChI=1/C7H6ClN3/c1-4-2-5(8)7-6(10-4)3-9-11-7/h2-3H,1H3,(H,9,11) |
94220-38-9 - Physico-chemical Properties
Molecular Formula | C7H6ClN3
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Molar Mass | 167.6 |
Density | 1.438g/cm3 |
Boling Point | 307.317°C at 760 mmHg |
Flash Point | 168.442°C |
Vapor Presure | 0.001mmHg at 25°C |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Refractive Index | 1.688 |
94220-38-9 - Introduction
[4,3-b]pyridine is an organic compound with the chemical formula C8H6ClN3, which is a nitrogen-containing aromatic compound. The following is a detailed description of its nature, use, formulation and safety information:
Nature:
-Appearance: [4,3-b]pyridine is a colorless to pale yellow crystalline solid.
-Melting point: about 160-162°C.
-Solubility: Soluble in common organic solvents, such as ethanol, carbon disulfide and dimethylformamide.
Use:
[4,3-b]pyridine is an important aromatic compound, often used in organic synthesis and pharmaceutical research.
-Organic synthesis: It can be used as a starting material or intermediate for organic synthesis reactions. For example, in the synthesis of indole compounds, 7-chloro and 5-methyl groups can be introduced by reacting with other reactants.
-Drug research: The compound can be used to study the interaction, activity and biological activity of aromatic compounds, and can also be used as the structural skeleton of some drugs.
Method:
[4,3-b]pyridine can be prepared by reacting an indole compound with a chlorine compound.
For example, 2,3-dibromoindole can be reacted with thionyl chloride under basic conditions to generate the corresponding chloroindole intermediate, which is then reacted with methylamine to obtain [4,3-b]pyridine.
Safety Information:
Since there is no specific safety data, laboratory safety procedures and good laboratory practices should be followed when using this compound. For detailed information on toxicity and precautions for use, the safety data sheet of the compound should be consulted.
Last Update:2024-04-09 21:04:16