Name | Hydroxypropyl-beta-cyclodextrin |
Synonyms | HBC HPCD HPBCD hpbcd HP-beta-cyclodextrin HYDROXYPROPYL-β-CYCLODEXTRIN Hydroxypyle beta cyclodextrin HYDROXYPROPYL-BETA-CYCLODEXTRIN Hydroxypropyl-beta-cyclodextrin 2-hydroxypropyl-beta-cyclodextrin 2-Hydroxypropy-.beta.-cyclodextrin (2-hydroxypropyl)-beta-cyclodextrin beta-Cyclodextrin, 2-hydroxypropyl ether beta-Cyclodextrin 2-hydroxypropyl ethers |
CAS | 94035-02-6 128446-35-5 136019-12-0 |
EINECS | 618-994-5 |
InChI | InChI=1/C105H196O56/c1-50(106)22-127-43-71-78-85(134-29-57(8)113)92(141-36-64(15)120)99(148-71)156-79-72(44-128-23-51(2)107)150-101(94(143-38-66(17)122)86(79)135-30-58(9)114)158-81-74(46-130-25-53(4)109)152-103(96(145-40-68(19)124)88(81)137-32-60(11)116)160-83-76(48-132-27-55(6)111)154-105(98(147-42-70(21)126)90(83)139-34-62(13)118)161-84-77(49-133-28-56(7)112)153-104(97(146-41-69(20)125)91(84)140-35-63(14)119)159-82-75(47-131-26-54(5)110)151-102(95(144-39-67(18)123)89(82)138-33-61(12)117)157-80-73(45-129-24-52(3)108)149-100(155-78)93(142-37-65(16)121)87(80)136-31-59(10)115/h50-126H,22-49H2,1-21H3 |
Molecular Formula | C54H102O39 |
Molar Mass | 1375.36 |
Melting Point | 267°C (dec.) |
Solubility | H2O: 45% (w/v) |
Appearance | White powder |
Storage Condition | 2-8°C |
MDL | MFCD00069372 |
Physical and Chemical Properties | This product is white or white amorphous or crystalline powder; odorless, slightly sweet taste; strong wetting. This product is very soluble in water, easily soluble in methanol and ethanol, and almost insoluble in acetone and chloroform. |
Safety Description | 24/25 - Avoid contact with skin and eyes. |
WGK Germany | 3 |
RTECS | GU2293332 |
This product is an etherate of beta-cyclodextrin and 1, 2-epoxypropane. The hydroxypropoxy group (-OCH2CHOHCH3) should be 19. 6% to 26.3% based on the anhydrous.
take 0.5ml of 5% aqueous solution of this product, put it in a 10ml test tube, add 2 drops of 10% tr • naphthol ethanol solution, shake well, slowly add human sulfuric acid lm l along the tube wall, at the interface of the two liquids, a purple ring appears.
take this product L. 0g, add water 40ml dissolved, according to the law (General 0631), p H value should be 5.0~7. 5.
Take 2. 5g of this product, add water 25M l to dissolve, check according to law (General rule 0901 and general rule 0902), the solution should be clear and colorless.
take 0. lg of this product and check it according to law (General rule 0801). Compared with the control solution made of 5. 0ml of standard sodium chloride solution, it should not be more concentrated (0. 05%).
take this product about l .O g, precision weighing, put it in a 10ml measuring flask, add water to dissolve and dilute to the scale, shake well, as a test solution; Another 50mg of beta-cyclodextrin reference, precision weighing, put 100ml measuring flask, add water to dissolve and dilute to the scale, shake, as a reference solution. According to high performance liquid chromatography (General rule 0512), amino bonded silica gel was used as filler; Acetonitrile-water (65 : 35) was used as mobile phase; column temperature 35°C. The reference solution and the test solution were injected into the liquid chromatograph, and the chromatograms were recorded. If there is a chromatographic peak in the chromatogram of the test solution that is consistent with the retention time of the peak of beta cyclodextrin, the peak area shall be calculated by the external standard method, and the beta cyclodextrin containing 0 .5% shall not be used.
take about lg of this product, accurately weigh it, put it in a 10ml measuring flask, add methanol to dissolve and dilute it to the scale, shake it well, and use it as a test solution. Take another 1, 2-propanediol about 501«8, weigh it accurately, put it in a measuring flask, dilute it to the scale with methanol, shake it well, and use it as a reference solution. Determined as residual solvent assay (General 0861). Using 100% polydimethylsiloxane chemical cross-linked capillary column for the column, the initial temperature is 7 0°C, at the rate of 10°C per minute heating to 100°C, then the temperature was increased to 2 20°C at a rate of 40 */min for 4 minutes; The inlet temperature was 2 50°C; The detector temperature was 2 8 0 1; theoretical plate number 1,2-propylene glycol peak calculation should not be less than 3000. The reference solution and the test solution were injected into the gas chromatograph respectively, and the chromatograms were recorded. According to the external standard method to calculate the peak area, containing 1,2-propylene glycol shall not exceed 0.5%.
take this product, according to the determination of moisture (General rule 0832 first method 1), the water content shall not exceed 6 .0%.
The l.O g of this product shall be taken for inspection according to law (General rule 0841), and the remaining residue shall not exceed.
The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).
hydroxypropyl base take this product about O.lg, precision weighing, according to the methoxy, ethoxy and hydroxypropoxy determination method (General 0712), that is obtained.
pharmaceutical excipients, packaging agents and stabilizers, etc.
light shielding, closed storage.