923282-64-8 - Names and Identifiers
923282-64-8 - Physico-chemical Properties
Molecular Formula | C5H3ClN4
|
Molar Mass | 154.56 |
Density | 1.653±0.06 g/cm3(Predicted) |
Boling Point | 348.3±22.0 °C(Predicted) |
pKa | 5.81±0.50(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
923282-64-8 - Introduction
7-Chloro-1H-pyrazolo[4,3-d]pyrimidine is an organic compound with the chemical formula C6H3ClN4. The following is a detailed introduction:
Nature:
-Appearance: Colorless to light yellow crystal or crystalline powder.
-Melting point: about 200-204°C.
-Solubility: Soluble in common organic solvents such as ethanol, dimethyl sulfoxide and dichloromethane.
Use:
- 7-Chloro-1H-pyrazolo[4,3-d]pyrimidine is an important organic synthesis intermediate, often used in the synthesis of other organic compounds. It can be used to prepare various compounds such as drugs, pesticides and dyes containing pyrazole and pyrimidine structures.
Method:
- 7-Chloro-1H-pyrazolo[4,3-d]pyrimidine can be synthesized by the following steps:
1. First, using 3,6-diaminopyrimidine as a starting material, sulfonation treatment was carried out by a sulfonated pyrimidine method to obtain 3,6-disulfonated pyrimidine.
2. reacting 3,6-disulfonic acid pyrimidine with methine hydrazine to generate an imine intermediate.
3. The imine intermediate reacts with thionyl chloride to generate 7-chloro -1H-pyrimido [4,3-D] pyrimidine.
Safety Information:
- 7-Chloro-1H-pyrazolo[4,3-d] The safety of pyrimidine has not been fully evaluated, so it is important to follow relevant safety procedures when using and handling.
-It may be toxic to humans and the environment, should avoid inhalation, skin contact or ingestion. Wear appropriate personal protective equipment during operation.
-If exposed or inhaled, rinse immediately with plenty of water and seek medical help.
-Observe local regulations when disposing of waste.
Last Update:2024-04-09 21:01:54