Dabigatran Etexilate Tetrahydrate(Dabigatran Etexilate Tetrahydrate) is a drug widely used to prevent and treat thrombosis. It is the hydrochloride tetrahydrate form of dabigatan ester (Dabigatran Etexilate).
Dabigatran Etexilate Tetrahydrate is a white crystalline powder, soluble in water and methanol, insoluble in ethanol and dichloromethane. It is a direct thrombus kinase inhibitor that prevents thrombus formation by inhibiting the activity of factor IIa.
Dabigatran Etexilate Tetrahydrate is mainly used in the following fields: prevention and treatment of venous thromboembolism, embolic stroke and embolic systemic embolism in patients with non-valvular atrial fibrillation, and surgical-related thromboembolism.
The preparation method of Dabigatran Etexilate Tetrahydrate includes the formation and crystallization process of dabigatan ester. In general, dabigatran etex is synthesized first, and then the Dabigatran Etexilate Tetrahydrate is prepared through the steps of crystallization, separation and drying.
When using Dabigatran Etexilate Tetrahydrate, you need to pay attention to some safety information. The drug may cause bleeding or an increased risk of thrombosis and should be used strictly according to the doctor's instructions. During use, regular monitoring of platelet count and liver function is required. The risk of interaction with other drugs also requires attention.