2-(tert-butyl)amino acetyl chloride hydrochloride is a pharmaceutical intermediate compound. It is a colorless or white crystalline powder with a pungent smell. It is corrosive and irritating to the skin, eyes and respiratory system.
The main use of 2-(tert-butyl)amino acetyl chloride hydrochloride is as an intermediate for synthetic drugs in the pharmaceutical industry. It can be used in the synthesis of anticancer drugs, antiviral drugs and antibiotics and other drugs.
The compound can be prepared by the following method: reacting dimethylacetamide and phosphorus trichloride to prepare 2-[(tert-butyl)amino] acetyl chloride, and then reacting with hydrochloric acid to prepare 2-(tert-butyl)amino acetyl chloride hydrochloride.
Because it is irritating and corrosive, appropriate protective measures need to be taken during use and handling. Wear protective glasses, protective gloves and protective masks and operate in a well-ventilated place. Avoid contact with skin and eyes, and prevent inhalation of its dust or gas. Wear protective clothing if necessary. During storage and transportation, contact with oxidants and combustibles should be avoided. Use and handle in accordance with appropriate laboratory specifications and regulations.