Molecular Formula | FeH2O4S |
Molar Mass | 153.92348 |
Solubility | Water (Slightly) |
Appearance | solution |
Color | Very Dark Red to Black |
Storage Condition | Room Temperature |
MDL | MFCD00081553 |
Use | Suitable for pigs and other livestock to prevent and treat iron deficiency anemia, promote growth and development |
Risk Codes | R40 - Limited evidence of a carcinogenic effect R42/43 - May cause sensitization by inhalation and skin contact. R43 - May cause sensitization by skin contact R45 - May cause cancer |
Safety Description | S23 - Do not breathe vapour. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36 - Wear suitable protective clothing. S36/37 - Wear suitable protective clothing and gloves. S53 - Avoid exposure - obtain special instructions before use. |
WGK Germany | - |
RTECS | NI2200000 |
Toxicity | LD50 i.v. in mice: 2240 mg Fe/kg (Beliles) |
This product is a complex of ferric hydroxide and dextran having a weight average molecular weight (Mw) of 5000 to 7500. The iron (Fe) content shall not be less than 25.0% calculated as the dried product.
take 0.10g of this product, put it in a 50ml Nessler's colorimetric tube, Add 10ml of water to shake to dissolve, add 1.0ml of standard iron stock solution and potassium thiocyanate solution (15g of potassium thiocyanate), add about 50ml of water to dissolve in a 100ml measuring flask, add 15ml of acetone, dilute with water to the scale, shake well) 15ml and 24ml of acetone, shake well, stand still, observe the color of the upper solution; If it develops, it shall not be deeper (0.2%) compared with of the standard iron stock solution and the control solution prepared by the same method.
take 0.25g of this product, add 2ml of water and 1 ml of sulfuric acid, heat until the solution is light yellow, let it cool, dilute to 0801 ml with water, take 2ml, and check according to law (general rule), not more concentrated (2.0%) than the control solution made from of standard sodium chloride solution.
take this product, dry to constant weight at 105°C, weight loss shall not exceed 5.0% (General rule 0831).
take 1.0g of this product, add 6ml of water and 4ml of nitric acid, heat it in water bath to a volume of about 2~3ml, let it cool, add 2ml of sulfuric acid, heat it in water bath to oxidize to white, if the oxidation is incomplete, add 1 ~ 2ml of nitric acid, then heat in water bath, cool, add 15ml of hydrochloric acid, heat to dissolve, add isobutyl acetate to extract 4 times, each time 8ml, discard the organic phase, take the water layer, set it on a water bath to evaporate to about 8ml, let it cool, add 1 drop of phenolphthalein indicator solution, neutralize it with ammonia test solution, then add 2ml of acetate buffer (pH 3.5), add water to 0821, inspection according to law (general principles the first law), containing heavy metals shall not exceed 20 parts per million.
take 0.4g of this product, add 0.5g of calcium hydroxide, mix well, slowly heat to complete carbonization, burn at 500~600°C to ash, cool, add 14ml of hydrochloric acid and 7ml of water to dissolve, transfer to distillation flask, add 0.5ml of acid-gasified stannous solution, distill to about 5ml, and introduce the distillate into an arsenic testing flask containing 10ml of water, inspection according to law (General Principles 0822 first law), shall comply with the provisions (0.0005%).
take about 0.3g of this product, weigh it accurately, put it in the iodine bottle, add 34ml of water and 2ml of sulfuric acid, heat the solution to show orange yellow, let it cool, add potassium permanganate solution dropwise, add hydrochloric acid 30ml and potassium iodide solution 30ml, plug, stand for 3 minutes, add water 50ml, with sodium thiosulfate titration solution (0.1 mol/L) titration, to the near end point, add 2ml of starch indicator solution, continue titration to blue disappeared. Each 1 ml of sodium thiosulfate titration solution (0.1 mol/L) corresponds to 5.585mg of Fe.
anti-anemia drugs.
light shielding, sealed storage.
This product contains iron dextran, iron (Fe) should be 90.0% ~ 110.0% of the label.
This product is sugar-coated tablets, remove the coating after Brown.
take this product, grind, take fine powder suitable for children (about 12.5mg equivalent to Fe), according to the identification of iron dextran item (1), (2) test, the same reaction was shown.
Take 20 tablets of this product, remove the coating, close weigh the tip, fine, precision weigh appropriate amount (about equivalent to Fe 0.lg ), according to the method under the item of iron dextran determination.
Same as iron dextran.
25mg (by Fe)
light shielding, sealed storage.
This product is a sterile colloidal solution of iron dextran. The iron (Fe) content shall be between 95.0% and 105.0% of the labeled amount.
This product is a dark brown colloidal solution.
with the internal volume pipette, take an appropriate amount of this product (about 0.lg of Iron), and measure it according to the method under the item of iron dextran.
Same as iron dextran.
calculated by Fe (l)2ml:50mg (2)4ml:lOOmg(3)2ml:lOOmg
light shielding, closed storage.
(IARC) carcinogen classification | 2B (Vol. 2, Sup 7) 1987 |
EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
Overview | Iron Dextran, also known as Iron dextran complex, Iron Dextran, Iron Dextran, is the weight average molecular weight (Mw)5000~7500 of dextran and iron hydroxide complexes, iron content of 25 ~ 30%; Because of its toxic side effects, stable nature, good solubility, high iron content is used as iron supplement in the pig industry; clinically, it is often used to identify the causes of chronic blood loss, malnutrition, pregnancy, children's development and other iron deficiency anemia. [Physical and chemical properties] Brown or Brown black crystalline powder. Slightly soluble in hot water, insoluble in ethanol. 5% of the aqueous solution is a dark brown colloidal solution with a pH of 5.2~6.5, which can be sterilized by hot pressing and filtration. Pharmacological action of anti-anemia drugs. Iron is a major component of hemoglobin and myoglobin. Hemoglobin is the major oxygen carrier in red blood cells. Myoglobin is the site of oxygen storage by muscle cells for the oxygen requirement of muscles during exercise. Most of the enzymes involved in the tricarboxylic cycle contain iron, or function only in the presence of iron. Therefore, in patients with iron deficiency after active supplementation of iron, in addition to accelerated hemoglobin synthesis, and tissue iron deficiency and reduced activity of iron-containing enzymes related to symptoms such as growth retardation, abnormal movement, lack of physical strength, mucosal tissue changes and skin and nail lesions can be gradually corrected. |
Clinical application | 1, such as anemia caused by insufficient intake of iron, partial diet in the daily diet or pregnant women, or adolescents and children of iron demand increases, if the food of iron deficiency, it may cause iron deficiency anemia, in this case can be supplemented with iron dextran treatment. Two, for gastrointestinal absorption disorders caused by iron deficiency anemia, such as chronic gastritis, gastric ulcer or other gastrointestinal diseases, resulting in iron absorption disorders, in this case you can take iron dextran treatment. Three, a variety of chronic blood loss caused by the treatment of iron deficiency anemia, such as peptic ulcer bleeding, bleeding hemorrhoids, female menorrhagia caused by iron deficiency anemia, can take dextran iron tablets treatment. At the same time taking iron dextran when combined with vitamin C, can effectively improve the absorption and utilization of iron. |
pharmacodynamics | Iron Dextran is a complex of iron and dextran, and the solution is intended for injection. After intramuscular injection, part of the iron was phagocytosed by macrophages into fibroblasts, and the rest of the iron was slowly removed (about 50% at 72h) and transferred to plasma via lymph nodes. Its absorption pathway is not controlled by the gastrointestinal tract, so the storage of iron is faster and the recovery is complete. But the rate of increase in hemoglobin is still the same as that of oral preparations. |
preparation method | 1. Preparation of low molecular weight (Mw5000 ~ 7500) dextran (1) dextran -20 hydrolysis method to take dextran -20 raw powder and water to prepare a concentration of 22% (w/w) solution, after heating and dissolving, concentrated hydrochloric acid was added until the acidity of the solution reached 0.1m, and then the solution was heated to reflux and hydrolyzed for 2H. Then, cooled to room temperature, neutralized with 10% (w/w)NaOH aqueous solution to pH 6~6.5; Under stirring, 95%(v/v) ethanol was added to precipitate the low molecular weight (Mw5000-7500). Dextran, then filtered, washed, dried, ready to use. (2) glucose anhydride -20 supernatant precipitation refining method to take glucose anhydride -20 supernatant, add 95%(v/v) ethanol to the solution system of ethanol content of 67%(v/v), after natural sedimentation for more than 10h, the viscous matter at the bottom of the tank is refined by powder adjustment to obtain low molecular weight (Mw5000 ~ 7500) dextran, which is dried and ready for use. 2. Preparation of iron dextran the dextran prepared above was heated and dissolved with water to prepare an aqueous solution with a concentration of 40%(w/w), and stirred at 90-95 ℃, within 20min, 20%(w/w)NaOH was added dropwise until the concentration of NaOH in the system was 1m; Then, the temperature was cooled to 55~60 ℃ and 40%(w/w)FeCl3 · 6H2O was added dropwise, The pH of the system is 5~6(pH test paper judgment), then use the pH meter to monitor the pH and add 2.5 (w/w) at the same time within 20% ~ 3H. NaOH and 40% (w/w)FeCl3 · 6H2O, then 20% (w/w)NaOH to adjust the pH to 6~7, the reaction was heated to 90~95 ° C. For 0.5H and then cooled to room temperature to obtain a dark brown dextran/ferric hydroxide complex colloidal solution. The colloidal solution is poured into 85 ~ 95% ethanol to precipitate, and the volume ratio of the two is controlled at 1 ∶ 3. The precipitated iron dextran is filtered, and then it is pulped, washed with 85 ~ 95% ethanol, filtration and finally drying in a desiccator at a temperature not exceeding 80 °c gives a dark brown iron dextran solid powder. |
Application | 1. Gastrointestinal malabsorption, chronic diarrhea or gastrointestinal surgery. 2. Can not tolerate oral iron, especially severe gastrointestinal disease taboo oral iron. 3. Bleeding that is not easy to control. Such as unresectable gastrointestinal malignant hemorrhage. 4. Children or patients with mental disorders difficult to oral administration. (2016-02-03) |
adverse reactions | 1. There are many adverse reactions of injection, and the indications and dosage must be strictly controlled. 2. Injection of iron is not controlled by the intestinal mucosa, so easy to cause symptoms of heavy metal poisoning. 3. IV injection prone to Flushing, mild Head Pain, dizziness, muscle Arthralgia, Nausea, Vomit, Abdominal Pain, Diarrhea, Fever, chills and reaction. 4. Intramuscular injection often causes local pain after injection. Severe cases can occur Nausea, Vomit, pale, blood pressure decreased, generally temporary. Occasionally cause allergic reactions (incidence of 1% ~ 2%), a very small number of anaphylactic shock can occur. |
contraindication | 1. Contraindicated in patients with iron overload or iron utilization disorder. 3. It is known to be contraindicated in patients with hypersensitivity to iron monosaccharides or disaccharides. Decompensation is contraindicated in patients with cirrhosis. 5. Patients with infectious hepatitis disabled. Disabled in patients with acute and chronic infection. It is contraindicated in patients with asthma, eczema or other atopic allergies. |
note | 1. Any parenteral administration of Iron Dextran can cause a fatal allergic reaction; This is more likely in patients with a history of drug allergy. Iron Dextran can only be administered in the case of immediate emergency measures; Administration to patients with autoimmune diseases or inflammation may cause Type III allergic reactions. 3. Intravenous injection of too fast may cause hypotension; Parenteral route of administration of iron may cause allergic or toxic reactions. 4. After the injection of hemoglobin no gradual increase should be immediately discontinued. 5. Iron Dextran can not be applied to the first pregnant women; For the second, third trimester and lactating women such as oral iron invalid or can not be taken orally, should be used under the guidance of a doctor. 6. May have adverse effects on infected children. |
drug interaction | vitamin C is taken with this product, which is beneficial to absorption. This product is equivalent to phosphate, tetracycline and tannic acid, which can hinder the absorption of iron. This product can reduce the absorption of levodopa, carbidopa, methyldopa and quinolones. If you are taking other drugs, the use of this product before Counseling of the doctor or pharmacist. |
Use | is suitable for preventing and treating iron deficiency anemia in pigs and other livestock, promoting growth and development |
production method | is a complex of dextran and iron. The dextran solution with the average molecular weight of 5000~7500 was complexed with ferric chloride. Firstly, the dextran solution was decolorized by activated carbon, and then mixed with ferric chloride solution in 701 styrene type weak basic anion exchange resin for elution. Concentrate the lotion and reprepare it. |
toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |