Name | Cellulose Acetate Phthalate |
Synonyms | cap-wako cellacetate Cellacefate acetylphthalylcellulose ELLULOSE ACETATE PHTHALATE Cellulose Acetate Phthalate celluloseacetatemonophthalate Cellulose acetate phthalate NF Cellulose Acetate Phthalate API Cellulose Acetate Phthalate (CAP) Cellulose acetate hydrogen phthalate Cellulose acetate hydrogen 1,2-benzenedicarboxylate |
CAS | 9004-38-0 |
InChI | InChI=1/C8H6O4.C2H4O2/c9-7(10)5-3-1-2-4-6(5)8(11)12;1-2(3)4/h1-4H,(H,9,10)(H,11,12);1H3,(H,3,4)/p-2 |
Molecular Formula | C116H116O64 |
Molar Mass | 2534.12 |
Solubility | Practically insoluble in water, freely soluble in acetone, soluble in diethylene glycol, practically insoluble in ethanol (96 per cent) and in methylene chloride. It dissolves in dilute solutions of alkali hydroxides |
Appearance | neat |
Storage Condition | 2-8℃ |
Use | Used as pharmaceutical excipients, enteric excipients |
Hazard Symbols | Xn - Harmful |
Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
WGK Germany | 3 |
RTECS | FJ5692000 |
HS Code | 39129010 |
This product was prepared by condensation of partially acetylated cellulose with phthalic anhydride. The benzoic acid formyl group (C8Hs()3) should be 30 based on free acid and anhydrous. 0% to 36%. 0%, acetyl (C2H30) should be 21. 5% ~ 26. 0%.
take this product, with a crusher or grinding machine after grinding, take the powder, with the bromine tablet method, the infrared absorption spectrum should be consistent with the reference product (General 0402).
Take 15g of this product by precision weighing (based on Anhydrous), put it in a plug Erlenmeyer flask, add 8 5g of acetone-water (249=1) solution, shake until it is completely dissolved, determination of dynamic viscosity in accordance with the law (General Principles 0633 first method), select the different inner diameter of the capillary, so that the time allowed for more than 200 seconds. The viscosity should be 45 to 90MPa · s.
take this product about 0.5g, precision weighing, plus anhydrous ethanol-two gas methane (3=2) mixed solution instead of anhydrous methanol as solvent to dissolve (if the test sample is difficult to dissolve, use dehydrated ethanol instead of anhydrous ethanol), according to the determination of water content (General rule 0832 first method 1), water content should not exceed 5.0%.
take about 3.0g of this product, weigh it accurately, put it in a measuring flask, add 100ml of methanol solution (1-2), plug it, shake it for 2 hours, filter it, wash the iodine flask and the residue twice with methanol solution (1-2), 10ml each time, combine the washing liquid and filtrate, add 3 drops of phenolphthalein indicator solution, and titrate with sodium hydroxide solution (O.lraol/L) titration, and the results of the titration were corrected with a blank test. Each lm l sodium hydroxide titration solution (0. lm o l/L) is equivalent to 8.306 mg (:8 μ0 4). Calculated as anhydrous, the free acid content shall not exceed 3.0% based on phthalic acid (c8hs04).
take 0841g of this product and check it according to law (general rule). The remaining residue shall not exceed.
The residue left under the ignition residue item shall be inspected according to law (General Rule 0 8 2 1 second law) and shall not contain more than 10 parts per million of heavy metals.
take about lg of this product, weigh it accurately, put it in an Erlenmeyer flask, add 50 m l of ethanol-acetone (3: 2) mixture, shake to dissolve, phenolphthalein indicator solution 2 drops, with sodium hydroxide titration solution (O .lm o l/L) titration, and the results of the titration were corrected with a blank test. Each lm l sodium hydroxide titration solution (0. lm o l/L) corresponds to 14.91 mg of C8Hs0 3.
take this product about O .lg, precision weighing, set the mill mouth flask, precision plus sodium hydroxide titration solution (0. lm o l/L )2 5 m l, heating reflux for 30 minutes, cold, plus phenolphthalein indicator solution 5 drops, with hydrochloric acid titration solution (0.1 mol/L) titration, and the results of the titration were corrected with a blank test. Each l of sodium hydroxide titration solution (0.1 M o l/L) corresponds to 4.304mg of c2h30.
pharmaceutical excipients, coated village materials and release blockers.
light shielding, closed storage.
EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
Overview | cellulose is one of the most abundant renewable polymer resources in the world, lignin is present in plant cells in a bound or semi-bound manner. Since cellulose molecules have a strong interaction force due to hydrogen bonding of hydroxyl groups, and a large number of hydroxyl groups exist in the cellulose molecular chain, cellulose has a strong reactivity. Cellulose acetate phthalate is an enteric coating adjuvant for the preparation of capsules and tablets and is used as an inert substance, but it is also found to be biologically active during use and is used as an embolic material. |
Use | cellulose acetate phthalate is an enteric coating material for the preparation of capsules and tablets and is used as an inert substance, however, it is also found to be biologically active during use and is used as an embolic material. Cellulose acetate phthalate can be used in the preparation of a cellulose/hectorite hybrid composite for the purification of phenolic organic wastewater; And in the preparation of a pharmaceutical composition comprising a plurality of controlled release coated microparticles. used as pharmaceutical excipients, enteric excipients |
category | toxic substances |
flammability hazard characteristics | thermal decomposition of spicy and irritating smoke |
storage and transportation characteristics | low temperature ventilation and drying |
fire extinguishing agent | water, carbon dioxide, foam, dry powder |