Name | DL-Menthol |
Synonyms | Mentol Menthol DL-Menthol Racementhol p-Menthan-3-ol Menthol 89-78-1 Menthol Crystals DL-Menthol crystal component of Theragesic component of Dermoplast cyclohexanol,2-isopropyl-5-methyl- component of Robitussin cough drops Cyclohexanol, 2-isopropyl-5-methyl- (1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexanol (1R,2R,5S)-5-methyl-2-propan-2-yl-1-cyclohexanol |
CAS | 89-78-1 1490-04-6 |
EINECS | 201-939-0 |
InChI | InChI=1/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3/t8-,9+,10-/m1/s1 |
Molecular Formula | C10H20O |
Molar Mass | 156.27 |
Density | 0.89g/mLat 25°C(lit.) |
Melting Point | 34-36°C(lit.) |
Boling Point | 216°C(lit.) |
Specific Rotation(α) | -2 º (c=10, EtOH) |
Flash Point | 200°F |
JECFA Number | 427 |
Water Solubility | insoluble |
Solubility | Soluble in alcohol, ether, glacial acetic acid, liquid paraffin and petroleum ether, slightly soluble in water. |
Vapor Presure | 0.8 mm Hg ( 20 °C) |
Appearance | Crystalline Solid |
Color | Colorless to white |
Merck | 14,5837 |
BRN | 3194263 |
pKa | 15.30±0.60(Predicted) |
Storage Condition | Store below +30°C. |
Refractive Index | 1.4615 |
MDL | MFCD00001484 |
Physical and Chemical Properties | Density 1.36 |
Use | It is used in medicine for cooling oil, painkillers, etc. It is also used for making toothpaste, tooth powder, candy, beverage, spices, etc |
Risk Codes | R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. |
UN IDs | UN 1888 6.1/PG 3 |
WGK Germany | 2 |
RTECS | OT0350000 |
TSCA | Yes |
HS Code | 29061100 |
Toxicity | LD50 orally in rats: 3180 mg/kg (Jenner) |
Raw Materials | Peppermint oil |
Reference Show more | 1. [IF=9.776] Xian Shu et al."Biomimetic nanoparticles for effective mild temperature photothermal therapy and multimodal imaging."JOURNAL OF CONTROLLED RELEASE. 2022 Jul;347:270 |
colorless needle-like crystals with a cool mint aroma. Soluble in ethanol, acetone, ether, benzene and chloroform and other organic solvents, water-soluble. The chemical properties were relatively stable.
menthol can be isolated from peppermint oil.
This product is/-l-methyl -4-isopropylcyclohexanol-3, which is derived from the Labiatae plant menthahaplocyxbriq. Fresh lotus and leaf by steam evaporation harmonic, freezing, recrystallization. C1GH2t)0 should be 95.0%-105.0%.
The melting point of this product is 42~44°C (General 0612).
take this product, precision weighing, plus ethanol dissolution and quantitative dilution made per lml about containing O.lg of the solution, determined by law (General rule 0621), the specific rotation should be a 49 ° to a 50 °.
is widely used in daily flavor, food flavor, tobacco flavor. Generally, L10 mg/kg in chewing gum; 400mg/kg in candy; 130mg/kg in baked goods; 68mg/kg in ice cream; 35mg/kg in soft drinks.
take an appropriate amount of this product, accurately weigh it, add anhydrous ethanol to dissolve and quantitatively dilute it to make a solution containing about 50mg per lml as a test solution; Take an appropriate amount of menthol reference substance for precision measurement, A solution containing about 0.5mg of menthol per 1 ml was prepared by dissolving and quantitatively diluting with absolute ethanol as a control solution. According to the chromatographic conditions under the content determination item, wherein the column temperature is 110 ° c., the reference solution is injected into the gas chromatograph to adjust the detection sensitivity, make the peak height of the main component chromatographic peak to be 20% ~ 30% of the full scale; Then take the precision quantity for test
The product solution and the control solution were 1/J, respectively, the human gas chromatography was injected, and the chromatogram was recorded to 2 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test sample, the sum of each impurity peak area shall not be greater than the main peak area of the reference solution (1. 0%).
Take 2g of this product, put it in an evaporation dish that has been dried to constant weight, heat it on a water bath, and then dry it at 105 ° C. To constant weight. The remaining residue should not pass 1 mg.
lead shall not exceed 5 parts per million and cadmium shall not exceed 3 parts per million as determined by the methods for determination of lead, cadmium, arsenic, mercury and copper (General rule 2321); arsenic must not exceed 2 parts per million; Mercury must not exceed 2 parts per million; Copper must not exceed 20 parts per million.
measured by gas chromatography (General 0521).
pharmaceutical excipients, flavors and fragrances.
sealed and kept in a cool place.