874219-29-1 - Names and Identifiers
874219-29-1 - Physico-chemical Properties
Molecular Formula | C11H13BFNO4
|
Molar Mass | 253.03 |
Density | 1.37±0.1 g/cm3(Predicted) |
Melting Point | 138-140 |
Boling Point | 496.7±55.0 °C(Predicted) |
Flash Point | 254.2°C |
Vapor Presure | 1.1E-10mmHg at 25°C |
pKa | 8.12±0.10(Predicted) |
Storage Condition | Keep Cold |
Refractive Index | 1.566 |
874219-29-1 - Risk and Safety
Hazard Symbols | Xi - Irritant
|
Hazard Note | Irritant/Keep Cold |
874219-29-1 - Introduction
[4-fluoro-3-(morpholine-4-carbonyl)phenyl]boronic acid is an organic compound whose chemical formula is C12H12BFO4N. The following is a detailed description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: White or off-white solid
-Melting point: about 119-122°C
-Molecular weight: 281.04g/mol
-Solubility: Soluble in some organic solvents, such as chloroform and dichloromethane
Use:
[4-fluoro-3-(morpholine-4-carbonyl)phenyl]boronic acid can be used as an important reagent in organic synthesis and has the following main uses:
-It can alkylate with other compounds to form substituted aromatic hydrocarbons.
-It can be used for cross-coupling reactions in organic synthesis, such as Suzuki coupling reactions, to construct complex organic frameworks.
Preparation Method:
The preparation of [4-fluoro-3-(morpholine-4-carbonyl)phenyl]boronic acid typically involves several steps.
-First, morpholine-4-carbonyl benzeneborate was obtained by synthesis.
-Next, 4-fluorobenzene borate is reacted with an ester to produce [4-fluoro-3-(morpholine-4-carbonyl)phenyl]boronic acid ester.
-Finally, the ester is hydrolyzed to give [4-fluoro-3-(morpholine-4-carbonyl)phenyl]boronic acid.
Safety Information:
[4-fluoro-3-(morpholine-4-carbonyl)phenyl]boronic acid is a chemical that needs to be used under suitable laboratory conditions and follow suitable safe operating procedures. Its safety information is as follows:
-May cause irritation to the eyes, skin and respiratory system, so wear appropriate personal protective equipment such as gloves, goggles and protective masks during use.
-When encountering skin or eyes, rinse quickly with plenty of water and seek medical help.
-During storage and handling, it should be placed in a sealed container and avoid contact with oxidants and strong acids.
Please note that this is only general information. In the specific use or handling of the compound, the relevant safety data sheet and operating manual should be consulted to ensure safety.
Last Update:2024-04-10 22:29:15