Name | Mannitol |
Synonyms | Maitol hexitol NSC 9256 Mannitol MANNITOL AI3-19511 CB4720971 D-Mannitol L-altritol DL-Mannitol MANNITOL USP Mannidex 16700 D-(-)-Mannitol Hexahydroxyhexane |
CAS | 87-78-5 69-65-8 |
EINECS | 201-770-2 |
InChI | InChI=1/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6+/m0/s1 |
Molecular Formula | C6H14O6 |
Molar Mass | 182.17 |
Density | 1.596 |
Melting Point | 167°C |
Boling Point | 494.9°C |
Specific Rotation(α) | 141 o (C= USP-DIRECTIVES) |
Flash Point | 292.6°C |
Water Solubility | 177.3g/L(25 ºC) |
Solubility | Soluble in water, slightly soluble in ethanol |
Vapor Presure | 7.22E-12mmHg at 25°C |
Appearance | White needle crystal |
pKa | pKa 13.50(H2O,t =18)(Approximate) |
Storage Condition | Inert atmosphere,Room Temperature |
Sensitive | Easily absorbing moisture |
Refractive Index | 1.5970 (estimate) |
MDL | MFCD00064287 |
Physical and Chemical Properties | Density 1.52 melting point 167-170°C boiling point 295°C specific optical rotation 141 ° (c = USP-directives) water-soluble soluble properties mannitol is a six-membered alcohol, white needle-like crystal, taste like glucose soluble in water and hot methanol, ethanol, insoluble in ether |
Use | Used as analytical reagents, but also for the synthesis of resins and drugs |
Safety Description | S24/25 - Avoid contact with skin and eyes. |
HS Code | 29054300 |
Raw Materials | Dextrose Anhydrate Sodium hydroxide Hydrochloric acid |
Reference Show more | 1. Jiang Yong-hong, Zhang Xiao-Feng, Han Ping, et al. Optimization of extraction and determination of cordycepic acid in mycelial symbionts of Cordyceps militaris from coarse cereals [J]. Journal of Henan University of Technology (Natural Science Edition), 2017(1). 2. Liu Sha, Zhang Xiaojuan, Wang Wei, etc. Preliminary Study on the synthesis of active components of Cordyceps Snow Peak by liquid fermentation [J]. China Pharmacy, 2017, 28(022):3079-3083. 3. Zhang Zewen, Tan Jidan, Li Xiaohua, etc. Preliminary Study on Artificial culture conditions of Cordyceps cicadae [J]. Chemical and Biological Engineering, 2019, 036(007):12-14,28. 4. Li Min, Peng Xiaochen, Yang Sassa. Study on molding process and preliminary evaluation of Chinese Medicine compound granules of qinggan antipyretic prescription [J]. West China Pharmaceutical Journal, 2019, v.34(06):22-25. 5. Yang Yongchao, Wang Zhongyuan, Yang Xiaozhen, etc. Cloning and functional analysis of ClP5CS gene from watermelon [J]. Journal of Northwest Sci-Tech University of Agriculture and Forestry (Natural Science Edition), 2018, v.46;No.337(10):95-106. 6. Li Biao, Li Chengjie, Chen Shuangyang, et al. Optimization of cooking technology and non-volatile characteristic flavor compounds of mushroom soup [J]. Journal of Food Science and Technology, 36(1). 7. Tian Lei, Li Enyuan, Guan Tongwei, Tang Shukun, Liu Xiaofei, Zhang Xiaoping. Diversity and screening of functional enzymes and antibacterial activity of culturable halophilic bacteria in Aiding Lake [J]. Microbiology, 2017,44(11):2575-2587. 8. Ma Ning, Wang Chao-yi, Fang Dong Road, etc. Flavor variation of Flammulina velutipes packaged with polyethylene film during cold storage [J]. China Agricultural Science, 2019, 52(08):146-159. 9. Chen Weizhu, Jin Wenhui, Zhang Yi, Chen Hui, Hong Zhu. Determination of mannitol in kelp by ion chromatography [J]. Journal of Food Safety and quality testing, 2021,12(03):914-918. 10. Fei Li. Study on the pathway of rare ginsenoside transformation by Cordyceps fungi and the screening and mechanism of lipid-lowering saponins [D]. Shenyang Agricultural University, 2021. 11. Zhang Cong. Effects of endogenous sphingosine metabolites on rat retinal microvascular endothelial cells [J]. Beijing University of Chinese Medicine, 2020. 12. Liu Xinye, Li Yunshu, Ma Qi, Wu Zijian, Xu Huaide, Li Mei. Effects of different drying methods on taste components of pleurotus eryngii [J]. Food Research and Development, 2020,41(16):8-13. 13. Xin, Xiao Feng, et al. "Mechanism of essential mucosal barrier function in a rat model of chronic pulmonary disease: An observational study." Experimental and therapeutic medicine 12.3 (2016): 1331-1336.https://doi.org/10.3892/etm.2016.3493 14. Li, X., Guo, Y., Zhuang, Y., Qin, Y. and Sun, L. (2018), Nonvolatile taste components, nutritional values, bioactive compounds and antioxidant activities of three wild Chanterelle mushrooms. Int J Food Sci Technol, 53: 1855-1864. https://doi.org/10.1111/ij 15. [IF=4.451] Yang Yang et al."Deciphering the multicomponent synergy mechanism from a systems pharmacology perspective: Application to Gualou Xiebai Decoction for coronary heart disease."J Funct Foods. 2018 Aug;47:143 16. [IF=7.46] Xiaofeng Nie et al."High-throughput dielectrophoretic cell sorting assisted by cell sliding on scalable electrode tracks made of conducting-PDMS."Sensor Actuat B- Chem. 2021 Jan;327:128873 17. [IF=6.4] Yue Sun et al."Primary Studies on Construction and Evaluation of Ion-Sensitive in situ Gel Loaded with Paeonol-Solid Lipid Nanoparticles for Intranasal Drug Delivery."Int J Nanomed. 2020; 15: 3137-3160 18. [IF=6.321] Xuemei Wen et al."Preparation and In Vitro/In Vivo Evaluation of Orally Disintegrating/Modified-Release Praziquantel Tablets."Pharmaceutics. 2021 Oct;13(10):1567 19. [IF=5.537] Feng Wang et al."Roles of antioxidant capacity and energy metabolism in the maturity-dependent chilling tolerance of postharvest kiwifruit."Postharvest Biol Tec. 2020 Oct;168:111281 20. [IF=5.396] Han Liu et al."Astaxanthin attenuates D-galactose-induced brain aging in rats by ameliorating oxidative stress, mitochondrial dysfunction, and regulating metabolic markers."Food Funct. 2020 May;11(5):4103-4113 21. [IF=4.616] Zhongle Zhang et al."A one-step molded microfluidic chip featuring a two-layer silver-PDMS microelectrode for dielectrophoretic cell separation."Analyst. 2020 Aug;145(16):5603-5614 22. [IF=4.411] Zhixin Wang et al."Rapid Characterization of Chemical Components in Edible Mushroom Sparassis crispa by UPLC-Orbitrap MS Analysis and Potential Inhibitory Effects on Allergic Rhinitis."Molecules. 2019 Jan;24(16):3014 23. [IF=4.142] Wang Chenxi et al."Systematic quality evaluation of Peiyuan Tongnao capsule by offline two-dimensional liquid chromatography/quadrupole-Orbitrap mass spectrometry and adjusted parallel reaction monitoring of quality markers."Anal Bioanal Chem. 2019 Nov;4 24. [IF=3.215] Sun Peng et al."The role and mechanism of abscisic acid in mitigating the adverse impacts of high temperature in Gracilariopsis lemaneiformis."J Appl Phycol. 2022 Mar;:1-15 25. [IF=4.35] Lijuan Chen et al."Study on the Preparation, Characterization, and Stability of Freeze-Dried Curcumin-Loaded Cochleates."Foods. 2022 Jan;11(5):710 26. [IF=3.246] Xu Renjie et al."Fabrication of Stable Apigenin Nanosuspension with PEG 400 as Antisolvent for Enhancing the Solubility and Bioavailability."Aaps Pharmscitech. 2022 Jan;23(1):1-11 27. [IF=5.89] Yuanyuan Jin et al."Preparation and Evaluation of Liposomes and Niosomes Containing Total Ginsenosides for Anti-Photoaging Therapy."Frontiers in Bioengineering and Biotechnology. 2022; 10: 874827 |
prepared by electrolytic reduction or catalytic reduction of glucose or sucrose solution. Or extracted from kelp, seaweed.
This product is D-mannitol. The content of C6H1406 shall be between 98.0% and 102.0% based on the dry product.
The melting point of this product (General 0612) is 166~1701.
take this product about lg, precision weighing, put 100ml measuring flask, add ammonium molybdate solution (l-10)40ml, then add 0.5mol/L sulfuric acid solution 20ml, diluted with water to the scale, shake, measured at 25°C according to law (General 0621), specific rotation of 137 ° to 145 °.
sweeteners, nutritional supplements, quality improvers, anti-stick agents, etc. With low calorie, low sweetness, can be used instead of sugar for diabetes, obesity patients with special food, but also chewing gum and xingjiu medicine additives.
oral LD50 was 22000mg/kg in mice and 17300mg/kg in rats.
Take 5.0g of this product, add 50ml of water to dissolve, add 3 drops of phenolphthalein indicator solution and 0.02 ml of sodium hydroxide titration solution (0.30 mol/L), which should be pink.
take 1.5g of this product, Add 10ml of water to dissolve, the solution should be clear and colorless; If it is turbid, it should not be more concentrated compared with No. 1 turbidity standard solution (General rule 0902 first method).
take this product, add water to dissolve and dilute to make a solution containing 50mg per lml as a test solution; Take lml for precision measurement, put it in a 100ml measuring flask, dilute it with water to the scale, as a control solution; Another mannitol and sorbitol each 0.5G, put in a 100ml measuring flask, add water to dissolve and dilute to the scale, as a system applicable solution. According to the high performance liquid chromatography (General 0512) test, a strong cation calcium type exchange column (or a column with equivalent separation efficiency) with sulfonated crosslinked styrene divinylbenzene copolymer as the filler, and water as the mobile phase, the flow rate was 0.5ml per minute, the column temperature was 80°C, the refractive index detector, and the detection temperature was 55°C. The system applicable solution 20u1 was injected into the liquid chromatograph, and the chromatogram was recorded. The resolution between the mannitol peak and the sorbitol peak should be greater than 2.0. 20ul of the test solution and the control solution were respectively injected into the human liquid chromatograph, and the chromatogram was recorded to 2 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be more than 2 times (2.0%) of the main peak area of the control solution. The chromatogram of the test solution is 0.05 times smaller than the main peak area of the control solution.
Take 5.0g of this product, put it in an Erlenmeyer flask, add 25ml of water to dissolve, add copper citrate solution (take 25g of copper sulfate, 50g of citric acid and 114g of anhydrous sodium carbonate, add 1000ml of water to dissolve, 20ml, heated to boiling, keep boiling for 3 minutes, quickly cool, add 2.4%(V/V) glacial acetic acid solution 0.025 ml and 20.0 mol/L Iodine titration solution ml, shake well, add 6%(V/V) hydrochloric acid solution 25ml (precipitate should be completely dissolved. If there is any precipitate, continue to add the hydrochloric acid solution until the precipitate is completely dissolved), titrate with sodium thiosulfate titration solution (0.05mol/L), and add 1 ml of starch indicator solution near the end point, titration was continued until the blue color disappeared. The volume of sodium thiosulfate titrant (0.05mol/L) consumed shall not be less than 12.8.
take 2.0g of this product and check it according to law (General rule 0801). Compared with the control solution made of 6.0ml of standard gasification sodium solution, it should not be more concentrated (0.003%).
take 2.0g of this product and check it according to law (General rule 0802). Compared with the control solution made of 0.01% of standard potassium sulfate solution, it should not be more concentrated ().
take this product l. Add 3 drops of ammonia test solution and 1 ml of gasified calcium test solution, shake well, heat in water bath for 15 minutes, then take out and cool; if turbidity occurs, and sodium oxalate solution [take sodium oxalate 0.1523g, put in 1000ml measuring flask, add water to dissolve and dilute to the scale, shake, each lml is equivalent to 0.1 mg of oxalate (C204)] 0.02% ml of control solution prepared by the same method should not be more concentrated ().
take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).
not more than 0.1% (General rule 0841).
take 2.0g of this product, add 23ml of water to dissolve, add 2ml of acetate buffer (pH 3.5), and check according to law (General rule 0821 first law), containing heavy metals shall not exceed 10 parts per million.
take this product l. Add 10ml of water to dissolve, add 5ml of dilute sulfuric acid and 0.5ml of potassium bromide bromide solution, and heat on a water bath for 20 minutes, keep a slight excess of bromine (if necessary, add potassium bromide bromide solution Dropwise), and add the water of evaporation at any time, cool, add hydrochloric acid 5ml and water to make 28ml, inspection according to law (General Principles 0822 first law), shall comply with the provisions (0.0002%).
take about 0.2g of this product, accurately weigh, put it in a 250ml measuring flask, add water to dissolve and dilute to the scale, shake well; Take 10ml of precision, put it in an iodine bottle, precision Add Sodium periodate solution [take sulfuric acid solution (l-20)90ml and Sodium periodate solution (2.3-1000) 110ml mixed] 50ml, put water bath heating for 15 minutes, let cool, add potassium iodide test solution 10ml, after 5 minutes, add lml of starch indicator solution to the end point and continue titration until the blue color disappears, the results of the titration were corrected by a blank test. Each 1 ml of sodium thiosulfate titration solution (0.05mol/L) is equivalent to 0.9109mg of C6H1406.
dehydration drugs.
light shielding, sealed storage.
This product is a sterile aqueous solution of mannitol. Containing Mannitol (C6H1406) shall be between 95.0% and 105.0% of the labeled amount.
This product is a clear colorless liquid.
with mannitol.
light shielding, closed storage.