849062-41-5 - Names and Identifiers
849062-41-5 - Physico-chemical Properties
Molecular Formula | C14H13BBrFO3
|
Molar Mass | 338.96 |
Density | 1.51g/cm3 |
Melting Point | 128-133°C(lit.) |
Boling Point | 494.4°C at 760 mmHg |
Flash Point | 252.8°C |
Vapor Presure | 1.37E-10mmHg at 25°C |
Storage Condition | Room Temprature |
Refractive Index | 1.605 |
849062-41-5 - Risk and Safety
Hazard Symbols | Xi - Irritant
|
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin.
|
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
|
WGK Germany | 3 |
849062-41-5 - Introduction
{3-bromo-2-[(4-fluorobenzyl)oxy]-5-methylphenyl}boronic acid is a kind of organic compound, the chemical formula is C14H13BFNO3, the molecular weight is 285.07g/mol.
Nature:
-Appearance: White crystal or crystalline powder
-Melting point: about 175-177°C
-Solubility: Soluble in some organic solvents such as chloroform, toluene, dichloromethane, etc., slightly soluble in water.
Use:
-As a reagent and intermediate in organic synthesis, it is often used to construct the bonding reaction of aromatic compounds, such as arylation reaction, fluorination reaction, etc.
-In drug research, it can be used as an important intermediate for the synthesis of drug molecules.
Preparation Method:
{3-bromo-2-[(4-fluorobenzyl)oxy]-5-methylphenyl}boronic acid can be synthesized by the following steps:
1. react magnesium bromide with 3-iodo -5-methyl phenyl borate in a suitable solvent to generate the corresponding borate ester compound.
2. The borate ester compound is reacted with 4-fluorobenzyl alcohol under acidic conditions to obtain the target product.
Safety Information:
- {3-bromo-2-[(4-fluorobenzyl)oxy]-5-methylphenyl} The impact of boronic acid on human health under routine operating conditions has not been fully understood, so laboratory safety procedures should be followed during use.
-It may be irritating to the eyes, skin and respiratory system, and personal protection should be paid attention.
Please ensure that when conducting experiments or using the compound, you strictly follow the safe operation guidelines and personal protection requirements of the chemical laboratory.
Last Update:2024-04-09 20:49:11